The importance of the exposome and allostatic load in the planetary health paradigm

Logan, Alan C.; Prescott, Susan L.; Haahtela, Tari; Katz, David L.

doi:10.1186/s40101-018-0176-8

Cited by 40 publications

(33 citation statements)

References 97 publications

(61 reference statements)

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“…The contact with the biodiversity of natural environment is largely subconscious, and in urban setting, much of it is lost. The concept of extinction of experience describes that loss . “Never been in a forest or seen a wild butterfly, more experience of air conditioned homes, offices, shopping centres and cars.”…”

Section: Discussionmentioning

confidence: 99%

A biodiversity hypothesis

Haahtela

2019

Allergy

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249

164

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Biodiversity hypothesis states that contact with natural environments enriches the human microbiome, promotes immune balance and protects from allergy and inflammatory disorders. We are protected by two nested layers of biodiversity, microbiota of the outer layer (soil, natural waters, plants, animals) and inner layer (gut, skin, airways). The latter inhabits our body and is colonized from the outer layer. Explosion of human populations along with cultural evolution is profoundly changing our environment and lifestyle. Adaptive immunoregulatory circuits and dynamic homeostasis are at stake in the newly emerged urban surroundings. In allergy, and chronic inflammatory disorders in general, exploring the determinants of immunotolerance is the key for prevention and more effective treatment. Loss of immunoprotective factors, derived from nature, is a new kind of health risk poorly acknowledged until recently.The paradigm change has been implemented in the Finnish allergy programme (2008-2018), which emphasized tolerance instead of avoidance. The first results are promising, as allergy burden has started to reduce. The rapidly urbanizing world is facing serious biodiversity loss with global warming, which are interconnected.Biodiversity hypothesis of health and disease has societal impact, for example, on city planning, food and energy production and nature conservation. It has also a message for individuals for health and well-being: take nature close, to touch, eat, breathe, experience and enjoy. Biodiverse natural environments are dependent on planetary health, which should be a priority also among health professionals. K E Y W O R D Sasthma, biodiversity, hygiene hypothesis, immune tolerance, microbiome

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Section: Discussionmentioning

confidence: 99%

A biodiversity hypothesis

Haahtela

2019

Allergy

Self Cite

249

164

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“…The average performance from two trials using the participants' dominant hand was used as the result for analysis. Since lifestyle is important to physical and health status [18][19][20], information on alcohol drinking (≥ 40 g/day in men, ≥ 20 g/day in women), current smoking (yes/no), exercise (at least 30 min twice per week), and menopause (yes/no only in women) was collected by interview.…”

Section: Methodsmentioning

confidence: 99%

Vitamin K deficiency, evaluated with higher serum ucOC, was correlated with poor bone status in women

Tanaka

Arima

Nishimura

et al. 2020

J Physiol Anthropol

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Background: An increase in serum undercarboxylated osteocalcin concentrations suggests vitamin K deficiency. Clinical intervention studies suggested that the vitamin K supplementation might contribute to preventing bone loss in postmenopausal women. Evidence on the relationship between serum undercarboxylated osteocalcin (ucOC) levels and bone parameters of quantitative ultrasound (QUS) is limited. We examined the correlation between serum ucOC concentrations and bone status as measured by QUS among middle-aged and older Japanese men and women. Methods: The subjects were community-dwelling men (n = 358) and women (n = 503) aged ≥ 40 years in Japan. Heel QUS parameters, including the stiffness index, speed of sound, and broadband ultrasound attenuation, were measured. Serum ucOC concentrations were measured by electrochemiluminescence immunoassay. Grip strength was measured in the dominant hand. Information on alcohol drinking, current smoking, exercise, and menopause in women was collected. Results: Serum ucOC concentrations were significantly associated with age in both sexes. Serum ucOC concentrations in men were higher at ≥ 80 years than those in the age groups of 40-49, 50-59, and 60-69 years. Serum ucOC concentrations in women were higher in the age groups of 50-59 and 60-69 years than those at 40-49 years. Partial correlation analysis adjusting for covariates (age, body mass index, grip strength, alcohol drinking, current smoking, and exercise in men; age, body mass index, grip strength, alcohol drinking, current smoking, exercise, and menopause in women) showed that serum ucOC concentrations were negatively significantly correlated with all QUS parameters in women. Serum ucOC concentrations were not correlated with them in men. Conclusions: Vitamin K deficiency, evaluated with higher serum ucOC, was correlated with poor bone status in women.

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“…The story of planetary health (or the voice of the planet) can be made audible through a deeper understanding of our biopsychosocial relationship to the Earth. Concepts such as 'nature relatedness', 'sense of place', 'topophilia', etc., help to provide a narrative surrounding the development of individual and community-level emotional connections to the land [52], and 'ecological grief' provides a story concerning the consequences of destroying those bonds [53].…”

Section: Planetary Healthmentioning

confidence: 99%

The Canmore Declaration: Statement of Principles for Planetary Health

Prescott

Logan²,

Albrecht

et al. 2018

Challenges

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The term planetary health—denoting the interdependence between human health and place at all scales—emerged from the environmental and preventive health movements of the 1970–80s; in 1980, Friends of the Earth expanded the World Health Organization definition of health, stating: “health is a state of complete physical, mental, social and ecological well-being and not merely the absence of disease—personal health involvesplanetary health”. Planetary health is not a new discipline; it is an extension of a concept understood by our ancestors, and remains the vocation of multiple disciplines. Planetary health, inseparably bonded to human health, is formally defined by the inVIVO Planetary Health network as the interdependent vitality of all natural and anthropogenic ecosystems (social, political and otherwise). Here, we provide the historical background and philosophies that have guided the network, and summarize the major themes that emerged at the 7th inVIVO meeting in Canmore, Alberta, Canada. We also provide the Canmore Declaration, a Statement of Principles for Planetary Health. This consensus statement, framed by representative participants, expands upon the 1986 Ottawa Charter for Health Promotion and affirms the urgent need to consider the health of people, places and the planet as indistinguishable.

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The importance of the exposome and allostatic load in the planetary health paradigm

Cited by 40 publications

References 97 publications

A biodiversity hypothesis

A biodiversity hypothesis

Vitamin K deficiency, evaluated with higher serum ucOC, was correlated with poor bone status in women

The Canmore Declaration: Statement of Principles for Planetary Health

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