We herein describe the establishment of the Helsinki Vascularized Composite Allotransplantation (VCA) program and its execution in the first two face transplant cases. Methods & patients: The Helsinki VCA program initially required the fulfillment of legal, hospital, financial, and ethical requirements. Thereafter, the assembling of a multidisciplinary team commenced. A team of Plastic, maxillofacial and ENT surgeons comprise the facial VCA team. The protocol involves collaboration with the Solid Organ Transplant (SOT) team, transplant immunology, immunosuppression, microbiology, psychiatric evaluation, well-defined VCA indi-1 AL and PL designed and performed the study, collected and analyzed data and wrote the paper. PL was the leader of the program. HM, HJ, JL, V-JA, SJ, A-JÄ, AE, SS, HI and AM all participated in the development of the face transplant program and collected and analyzed data and contributed to writing the paper.