The Importance of Systemic Inflammation Markers in the Survival of Patients with Complicated Colorectal Cancer, Operated in Emergency

Abstract

Introducere: Răspunsul inflamator joacă un rol critic în carcinogeneză. Există scoruri recente bazate pe răspunsul inflamator sistemic, cum ar fi raportul neutrofile/limfocite (NLR), raportul trombocite/limfocite (PLR), raportul limfocite/monocite (LMR), despre care s-a arătat că au valoare prognostică la pacienţii cu cancer. Aceste scoruri permit identificarea pacienţilor care vor avea un răspuns slab la tratament şi o supravieţuire de scurtă durată. Scopul acestui studio este de a evalua rolul prognostic al NLR, PLR, LMR şi PNI în termeni de supravieţuire la distanţă pentru bolnavii cu cancer colorectal, operaţi în urgenţă. Material şi Metode: Am inclus în studiu 391 de pacienţi internaţi şi operaţi pentru cancer colorectal complicat în clinica Chirurgie II a Spitalului Clinic Judeţean de Urgenţă "Sf. Ap. Andrei" din Galaţi, în perioada 2008-2017. Am analizat factorii paraclinici de inflamaţie sistemică NLR, PLR, LMR şi PNI.Ca factori de prognostic, au fost analizate curbele de supravieţuire. Rezultate: La pacienţii din lot, valorile crescute ale NLR, precum şi ale PLR au dus la creşterea riscului de deces (HR=7,581, 95% CI=(6.358,9.039), p value=0.000000, respective HR=1.043, 95% CI=(1.039, 1.047), p value=0.000000), iar valorile crescute ale LMR şi PNI au condus la scăderea acestui risc (HR=0.069, 95%

The Systemic Inflammation Marker NLR as a Prognostic Factor in Complicated Colorectal Cancer

“…We showed that the increased preoperative value of NLR was a negative prognostic factor for longterm survival, as found by other authors [23][24][25][26]. In a single study conducted in 2018 at the University of Leeds in the UK, the authors reported that elevated NLR values were associated with a high risk of death in univariate but not multivariate analysis [27].…”

Platelet-to-lymphocyte ratio and C-reactive protein as markers for colorectal polyp histological type

“…PLR measurements can provide important diagnostic and prognostic information for patients with resectable gastric cancer. Georgiana et al [ 8 ] retrospectively analyzed 391 patients who were admitted to the hospital and who underwent surgery for complicated CRC. In the multivariate regression analysis, the increase in the PLR resulted in an increased risk of death (hazard ratio (HR) = 1.024; 95% CI = 1.019.1.029; P value = 0.000000), and the PLR was thus considered an independent risk factor.…”

“…Recently, many studies have shown that the systemic inflammatory response is related to tumor progression. The platelet-to-lymphocyte ratio (PLR) and C-reactive protein (CRP), which are two inflammation-related biomarkers, have been confirmed to be prognostic indicators in early gastric cancer, gastrointestinal cancers, and CRC [6][7][8]. However, to our knowledge, no studies have reported the association among PLR, CRP, and the histological type of colorectal polyps.…”

Platelet-to-Lymphocyte Ratio and C-Reactive Protein as Markers for Colorectal Polyp Histological Type

“…Georgiana et al [8] retrospectively analyzed 391 patients who were admitted to the hospital and who underwent surgery for complicated CRC. In the multivariate regression analysis, the increase in the PLR resulted in an increased risk of death (hazard ratio (HR) = 1.024; 95% CI = 1.019.1.029; P value = 0.000000), and the PLR was thus considered an independent risk factor.…”

“…Recently, many studies have shown that the systemic in ammatory response is related to tumor progression. The platelet-to-lymphocyte ratio (PLR) and C-reactive protein (CRP), which are two in ammation-related biomarkers, have been con rmed to be prognostic indicators in early gastric cancer, gastrointestinal cancers, and CRC [6][7][8]. However, to our knowledge, no studies have reported the association among PLR, CRP, and the histological type of colorectal polyps.…”