The relationship between economic fluctuations and mortality is assessed with data from Spain during the years 1980-1997, when national unemployment oscillated between 7% and 24%. Mortality rates of the Spanish provinces are modeled in fixed-effect panel regressions as functions of the demographic structure and the economic conditions. Unemployment effects on general mortality, sex-specific mortality, and mortality for major causes of death are negative, i.e., death rates increase procyclically when joblessness diminishes in an economic expansion. Homicides and female suicides are only weakly related or unrelated to economic fluctuations, but male suicides escalate countercyclically during economic downturns.Re´sume´. L'article s'inte´resse aux relations entre fluctuations e´conomiques et mortalite´en Espagne sur la pe´riode 1980-1997, au cours de laquelle le taux de choˆmage a oscille´entre 7 et 24%. Un mode`le de re´gression a`effets constants sur donne´es de panel est applique´aux taux de mortalite´par provinces espagnoles, prenant en compte la structure de´mographique et les conditions e´conomiques. Le choˆmage a un effet ne´gatif sur la mortalite´totale, la mortalite´par sexe et les principales causes de de´ce`s. Autrement dit, les taux de mortalite´augmentent quand, en phase d'expansion e´conomique, le choˆmage diminue. Les homicides et les suicides fe´minins sont faiblement ou pas du tout lie´s aux fluctuations e´conomiques alors que les suicides masculins augmentent lorsque la situation e´conomique se de´te´riore.