The importance of Serum Interleukin-20 Levels in Patients with Behçet’s Disease

Enecik, M.E.; Mavi, Barış; Yücel, Çiğdem; Keskin, Göksal; Yıldız, Mehmet

doi:10.17219/acem/70523

Cited by 3 publications

(1 citation statement)

References 18 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IL‐20 is a cytokine belonging to the IL‐10 family. IL‐1β and TNF‐α have been found to induce IL‐20 secretion, especially from cells such as macrophages and synoviocytes 19 . IL‐20 is known to be a potent angiogenic, chemotactic, and proinflammatory cytokine associated with various chronic inflammatory disorders such as psoriasis, 20 atherosclerosis, 21 cancer, liver fibrosis, and rheumatoid arthritis (RA).…”

Section: Introductionmentioning

confidence: 99%

The effect of interleukin‐20 on periodontal tissue destruction in individuals with periodontitis

Yemenoglu,

Senkal,

Kose

et al. 2024

J of Periodontal Research

View full text Add to dashboard Cite

Background and ObjectivePeriodontitis is an inflammatory disease that destroys periodontal tissues. Interleukin‐20 (IL‐20), on the other hand, is known as a potent angiogenic, chemotactic, and pro‐inflammatory cytokine associated with various chronic inflammatory disorders. IL‐20 has a significant role in the regulation of osteoclastogenesis and osteoblastogenesis. This study aimed to evaluate the effect of IL‐20 on periodontal destruction.MethodsIn this study, a total of 60 participants were included, 30 of whom were systemically and periodontally healthy (control group), and 30 were systemically healthy but had periodontitis (periodontitis group). Gingival crevicular fluid (GCF) and serum samples were collected from the participants for biochemical analysis. Enzyme‐linked immunosorbent assay was used to determine the levels of IL‐20, tumor necrosis factor (TNF)‐α, IL1β/IL‐10, RANKL/osteoprotegerin (OPG), and matrix metalloproteinase‐8 (MMP8). For statistical analysis, the independent t‐test, Pearson correlation coefficients, and the Chi‐square test were used.ResultsGCF IL‐20, RANKL, RANKL/OPG, serum IL‐20, RANKL, RANKL/OPG, MMP‐8, TNF‐α, IL‐1B, and IL‐1β/IL‐10 values were found to be statistically significantly higher in the periodontitis group than in the control group. GCF OPG and serum IL‐10 values were found to be statistically significantly higher in the control group than in the periodontitis group. No statistically significant difference was observed between the groups in serum OPG values. A statistically significantly positive correlation was observed between serum IL‐20 value and serum RANKL, RANKL/OPG, MMP‐8, TNF‐α, IL‐1β values, and periodontal clinical parameters. The ROC curves showed: AUC = 0.788 for GCF IL‐20, and AUC = 1.000 for serum IL‐20.ConclusionAccording to the results of the study, IL‐20 was found to be associated with periodontitis. The role of IL‐20 in periodontal pathogenesis is related to osteoclastogenesis and collagen degradation. It is conceivable that IL‐20 may increase bone destruction by both affecting the RANKL/OPG ratio and proinflammatory cytokines.

show abstract

Section: Introductionmentioning

confidence: 99%

The effect of interleukin‐20 on periodontal tissue destruction in individuals with periodontitis

Yemenoglu,

Senkal,

Kose

et al. 2024

J of Periodontal Research

View full text Add to dashboard Cite

show abstract

Value of hematological indices versus VEGF as biomarkers of activity in Behçet’s disease

et al. 2019

View full text Add to dashboard Cite

Finding the Needle in the Haystack: Serological and Urinary Biomarkers in Behçet’s Disease: A Systematic Review

Arbrile

Radin

Medica

et al. 2023

IJMS

View full text Add to dashboard Cite

Urinary and serological markers play an essential role in the diagnostic process of autoimmune diseases. However, to date, specific and reliable biomarkers for diagnosing Behçet’s disease (BD) are still lacking, negatively affecting the management of these patients. To analyze the currently available literature on serological and urinary BD biomarkers investigated in the last 25 years, we performed a systematic literature review using the Population, Intervention, Comparison, and Outcomes (PICO) strategy. One hundred eleven studies met the eligibility criteria (6301 BD patients,5163 controls). Most of them were retrospective, while five (5%) were prospective. One hundred ten studies (99%) investigated serological biomarkers and only two (2%) focused on urinary biomarkers. One hundred three studies (93%) explored the diagnostic potential of the biomolecules, whereas sixty-two (56%) tested their effect on disease activity monitoring. Most articles reported an increase in inflammatory markers and pro-oxidant molecules, with a decrease in antioxidants. Promising results have been shown by the omics sciences, offering a more holistic approach. Despite the vast number of investigated markers, existing evidence indicates a persistent gap in BD diagnostic/prognostic indices. While new steps have been taken in the direction of pathogenesis and disease monitoring, international efforts for the search of a diagnostic marker for BD are still needed.

show abstract

The importance of Serum Interleukin-20 Levels in Patients with Behçet’s Disease

Cited by 3 publications

References 18 publications

The effect of interleukin‐20 on periodontal tissue destruction in individuals with periodontitis

The effect of interleukin‐20 on periodontal tissue destruction in individuals with periodontitis

Value of hematological indices versus VEGF as biomarkers of activity in Behçet’s disease

Finding the Needle in the Haystack: Serological and Urinary Biomarkers in Behçet’s Disease: A Systematic Review

Contact Info

Product

Resources

About