The importance of serum creatine phosphokinase level in the early diagnosis and microbiological evaluation of necrotizing fasciitis

Simonart, Thierry; Nakafusa, Junji; Narisawa, Yutaka

doi:10.1111/j.1468-3083.2004.01108.x

Cited by 21 publications

(11 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A total of 98 papers were included for full‐text screening . Of these, 90 papers were subsequently excluded, including 20 studies that did not specify the site of cellulitis…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A systematic review showing the lack of diagnostic criteria and tools developed for lower‐limb cellulitis

et al. 2019

View full text Add to dashboard Cite

SummaryBackgroundCellulitis can be a difficult diagnosis to make. Furthermore, 31% of patients admitted from the emergency department with suspected lower‐limb cellulitis have been misdiagnosed, with incorrect treatment potentially resulting in avoidable hospital admission and the prescription of unnecessary antibiotics.ObjectivesWe sought to identify diagnostic criteria or tools that have been developed for lower‐limb cellulitis.MethodsWe conducted a systematic review using Ovid MEDLINE and Embase databases in May 2018, with the aim of describing diagnostic criteria and tools developed for lower‐limb cellulitis, and we assessed the quality of the studies identified using the Quality Assessment of Diagnostic Accuracy Studies‐2 tool. We included all types of study that described diagnostic criteria or tools.ResultsEight observational studies were included. Five studies examined biochemical markers, two studies assessed imaging and one study developed a diagnostic decision model. All eight studies were considered to have a high risk for bias in at least one domain. The quantity and quality of available data was low and results could not be pooled owing to the heterogeneity of the findings.ConclusionsThere is a lack of high‐quality publications describing criteria or tools for diagnosing lower‐limb cellulitis. Future studies using prospective designs, validated in both primary and secondary care settings, are needed. What's already known about this topic? Diagnosing lower‐limb cellulitis on first presentation is challenging.Approximately one in three patients admitted from the emergency department with suspected lower‐limb cellulitis do not have cellulitis and are given another diagnosis on discharge. Consequently, this results in potentially avoidable hospital admissions and the prescription of unnecessary antibiotics.There are no diagnostic criteria available for lower‐limb cellulitis in the U.K. What does this study add? This systematic review has identified a key research gap in the diagnosis of lower‐limb cellulitis.There is a current lack of robustly developed and validated diagnostic criteria or tools for use in clinical practice.

show abstract

“…A total of 98 papers were included for full‐text screening . Of these, 90 papers were subsequently excluded, including 20 studies that did not specify the site of cellulitis…”

Section: Resultsmentioning

confidence: 99%

“…Bonnetblanc et al . investigated a modification of the LRINEC score, two studies focused on multiple laboratory and clinical markers and Radkevich et al . investigated coagulable factors .…”

Section: Resultsmentioning

confidence: 99%

A systematic review showing the lack of diagnostic criteria and tools developed for lower‐limb cellulitis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…7 A previous retrospective study comparing GAS and non-GAS NF revealed elevated CPK values early in the course of GAS NF, while most patients with non-GAS NF exhibited CPK values within the normal range. 21 It is suggested that GAS may exert a particular tropism and/or toxicity for muscle. A very high CRP level has been reported frequently in NF, particularly in GAS NF.…”

Section: Discussionmentioning

confidence: 99%

Monomicrobial necrotizing fasciitis in a single center: the emergence of Gram-negative bacteria as a common pathogen

Yahav

Duskin-Bitan

Eliakim‐Raz

et al. 2014

International Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…One possible reason for this low sensitivity is that the elevation of CK level in NF seems to depend on the types of causative bacteria. Simonart et al (5) reported that the majority of NF patients with group A β-haemolytic streptococci as the causative agent had elevated CK values early in the course of their disease, while most patients with other bacteria exhibited CK values within normal ranges (5). In our study, Cases 1 and 2 had group A β-haemolytic Streptococcus (S.) pyogenes, and Case 3 has group G S. dysgalactiae subsp.…”

Section: Discussionmentioning

confidence: 46%

Usefulness of Serum Procalcitonin for Early Discrimination Between Necrotizing Fasciitis and Cellulitis

Kato

Fujimoto²,

Honda³

et al. 2017

Acta Derm Venerol

View full text Add to dashboard Cite

show abstract

The importance of serum creatine phosphokinase level in the early diagnosis and microbiological evaluation of necrotizing fasciitis

Cited by 21 publications

References 16 publications

A systematic review showing the lack of diagnostic criteria and tools developed for lower‐limb cellulitis

A systematic review showing the lack of diagnostic criteria and tools developed for lower‐limb cellulitis

Monomicrobial necrotizing fasciitis in a single center: the emergence of Gram-negative bacteria as a common pathogen

Usefulness of Serum Procalcitonin for Early Discrimination Between Necrotizing Fasciitis and Cellulitis

Contact Info

Product

Resources

About