The importance of radical lobectomy in lung cancer

Ramsey, Harold E.; Cahan, William G.; Beattie, Edward J.; Humphrey, Charles D.

doi:10.1016/s0022-5223(19)42606-8

Cited by 55 publications

(7 citation statements)

References 19 publications

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“…(J Thorac Oncol. 2015;10: 930-936) E ver since Cahan 1 first introduced lymph node dissection (LND) of the pulmonary hilum and mediastinum combined with lobectomy (radical lobectomy) as an alternative to pneumonectomy in 1960 and Ramsey et al 2 subsequently demonstrated the prognostic impact of hilar and mediastinal LND in 1969, systematic LND has been accepted as a standard mode of surgery for resectable non-small-cell lung cancer (NSCLC) for over 50 years all around the world. This procedure has been believed to contribute to survival and/or to the determination of more accurate cancer staging.…”

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confidence: 99%

Mediastinal Nodal Involvement in Patients with Clinical Stage I Non–Small-Cell Lung Cancer: Possibility of Rational Lymph Node Dissection

Haruki

Aokage

Miyoshi

et al. 2015

Journal of Thoracic Oncology

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It would be acceptable to perform selective LND in patients with c-stage I NSCLC with ground glass opacity- predominant tumor. Elevated serum carcinoembryonic antigen was associated with upper mediastinal lymph node involvement in lower-lobe primary lung adenocarcinoma with radiologically solid-predominant tumor. We should be careful when applying selective LND to patients with solid-predominant tumor, especially located in the lower lobe.

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confidence: 99%

Mediastinal Nodal Involvement in Patients with Clinical Stage I Non–Small-Cell Lung Cancer: Possibility of Rational Lymph Node Dissection

Haruki

Aokage

Miyoshi

et al. 2015

Journal of Thoracic Oncology

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“…The first surgeon using segmentectomy for lung cancer treatment was Richard Overholt (2). The gold standard of primary lung cancer treatment was for decades lobectomy (3,4). For patients with limited ventilatory function, the extent of pulmonary resection is limited in a way that a lobectomy is contraindicated.…”

Section: Segmentectomymentioning

confidence: 99%

Clarification of the resection line non-intubated segmentectomy using indocyanine green

et al. 2019

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“…Interestingly, nine years later, in 1960, Cahan described radical lobectomy—the removal of a lobe with specific lymphadenectomy depending on the lobar location of the primary tumor—and stated that radical lobectomy should be reserved for those patients who could not undergo radical pneumonectomy [ 4 ]. It was not considered an oncologically sound operation at that time, although by the end of the decade, radical lobectomy had gained credit as a consolidated operation for lung cancer [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The Evolving Concept of Complete Resection in Lung Cancer Surgery

Rami–Porta

2021

Cancers

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Different definitions of complete resection were formulated to complement the residual tumor (R) descriptor proposed by the American Joint Committee on Cancer in 1977. The definitions went beyond resection margins to include the status of the visceral pleura, the most distant nodes and the nodal capsule and the performance of a complete mediastinal lymphadenectomy. In 2005, the International Association for the Study of Lung Cancer (IASLC) proposed definitions for complete, incomplete and uncertain resections for international implementation. Central to the IASLC definition of complete resection is an adequate nodal evaluation either by systematic nodal dissection or lobe-specific systematic nodal dissection, as well as the integrity of the highest mediastinal node, the nodal capsule and the resection margins. When there is evidence of cancer remaining after treatment, the resection is incomplete, and when all margins are free of tumor, but the conditions for complete resection are not fulfilled, the resection is defined as uncertain. The prognostic relevance of the definitions has been validated by four studies. The definitions can be improved in the future by considering the cells spread through air spaces, the residual tumor cells, DNA or RNA in the blood, and the determination of the adequate margins and lymphadenectomy in sublobar resections.

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The importance of radical lobectomy in lung cancer

Cited by 55 publications

References 19 publications

Mediastinal Nodal Involvement in Patients with Clinical Stage I Non–Small-Cell Lung Cancer: Possibility of Rational Lymph Node Dissection

Mediastinal Nodal Involvement in Patients with Clinical Stage I Non–Small-Cell Lung Cancer: Possibility of Rational Lymph Node Dissection

Clarification of the resection line non-intubated segmentectomy using indocyanine green

The Evolving Concept of Complete Resection in Lung Cancer Surgery

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