The importance of proper vehicle selection in the detection of minoxidil sensitivity

Whitmore, S. E.

doi:10.1001/archderm.128.5.653

Cited by 7 publications

(7 citation statements)

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“…Minoksidilin etkinliği üzerine yapılan randomize kontrollü bir çalışmada 393 hasta değerlendirmeye alınmış ve çalışma sonucunda minoksidil tedavisi alan hastalarda non-vellus saç sayısında anlamlı düzeyde artış saptandığı bildirilmiştir (18). Topikal kullanımı yan etki açısından güvenli bir uygulama olmasına karşın solüsyon formulasyonunda yer alan propilen glikole bağlı hastalarda düşük oranda olsa da kontakt dermatit izlenebilmektedir (19). Ayrıca bazı yayınlarda minoksidilin…”

Section: Discussionunclassified

The Evaluation of Efficacy and Safety of Topical Saw Palmetto and Trichogen Veg Complex for the Treatment of Androgenetic Alopecia in Men

Arca¹,

Açıkgöz²,

Yeniay³

et al. 2014

tdd

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Androgenetik alopesi (AGA), saçlı derinin frontal ve parietal bölgelerdeki kıl folliküllerinin minyatürizasyonuyla karakterize özel bir alopesi tipidir. Bu çalışmada AGA'sı olan erkek hastalarda saw palmetto ve %10 trichogen veg kompleksi (TVK) içeren saç losyonunun etkinlik ve güvenilirliğini değerlendirmeyi amaçlandık. Yöntemler: 2011-2012 yılları arasında AGA tedavisi amacıyla hastanemize başvuran ve dört ay süreyle topikal saw palmetto ve TVK tedavisi almış olan erkek hastalar çalışmaya dahil edildi. Hastaların dosyalarından, verteks fotoğrafları ve trikoscan sonuçları incelemeleri dikkate alınarak 25 hastanın kayıtları değerlendirmeye uygun kabul edildi. Elde edilen veriler SPSS programı ile analiz edildi. Bulgular: Tedavi öncesine oranla toplam saç sayısında %11,9'luk bir artış saptandı. Anagen/telogen saç oranının ise tedavi öncesiyle karşılaştırıldığında %38 oranında arttığı izlendi. Verteks fotoğraflarının değerlendirilmesine göre gözlemciler hastaların %48'inde düzelme olduğunu, %36'sında ise bir değişiklik olmadığını belirttiler. Sonuç: Çalışma sonucunda topikal saw palmetto ve TVK'nın AGA tedavisinde etkili ve güvenilir olduğu izlendi. Daha geniş hasta gruplarında yapılacak randomize kontrollü çalışmalar topikal saw palmetto ve TVK'nın etkinliği hakkında daha kesin bilgiler ortaya koyacaktır.

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Section: Discussionunclassified

The Evaluation of Efficacy and Safety of Topical Saw Palmetto and Trichogen Veg Complex for the Treatment of Androgenetic Alopecia in Men

Arca¹,

Açıkgöz²,

Yeniay³

et al. 2014

tdd

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“…She was also sensitive to minoxidil, but not retinoic acid or propylene glycol. Contact allergic dermatitis to minoxidil is well documented, albeit rare, with only 13 cases identified from 1900 patients involved in the minoxidil phase III at a rate of 0.68% 11 …”

Section: Discussionmentioning

confidence: 99%

Sensitization to saw palmetto and minoxidil in separate topical extemporaneous treatments for androgenetic alopecia

2002

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“…[4] These included vascular patterns (simple loops, twisted loops and arborizing lines), follicular/perifollicular patterns (yellow dots, empty ostia, white dots, peripilar signs), white scales, yellow scales, follicular plugging, honeycomb pattern and short regrowing hairs and hair diameter diversity. Findings were graded from 0-4, according to severity in 20-fold magnifications.…”

Section: Methodsmentioning

confidence: 99%

“…[3] Patients with scalp itching during topical minoxidil treatment should undergo patch-testing with the minoxidil lotion (2% or 5% in propylene glycol, ethanol and water) and propylene glycol 5% in petrolatum and 30% in water as testing minoxidil in other vehicles may yield false-negative results. [4]…”

Section: Introductionmentioning

confidence: 99%

Videodermoscopy does not enhance diagnosis of scalp contact dermatitis due to topical minoxidil

et al. 2009

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Background:Videodermoscopy (VD) is a noninvasive diagnostic tool that provides useful information for the differential diagnosis of scalp disorders.Objectives:The aim of this study was to investigate if dermoscopy may help the clinician in the diagnosis of contact dermatitis of the scalp.Materials and Methods:We analyzed the dermoscopic images taken from 7 patients with contact dermatitis due to topical minoxidil, 6 patients complaining of intense scalp itching during treatment with topical minoxidil but with negative patch tests and 19 controls. The following dermoscopic patterns described for scalp diseases were evaluated: Vascular patterns (simple loops, twisted loops and arborizing lines), follicular/perifollicular patterns (yellow dots, empty ostia, white dots, peripilar signs), white scales, yellow scales, follicular plugging, hair diameter diversity, honeycomb pattern and short regrowing hairs. Findings were graded from 0-4, according to severity in 20-fold magnifications. Statistical analysis included univariate analysis and Chi-square test by SPSS version 12.Results:There were no statistical differences in the analysis of the vascular patterns and scales between the 3 groups. Conclusions:We were not able to detect dermoscopic features that can help the clinician in distinguishing scalp contact dermatitis due to topical minoxidil from other conditions that cause severe scalp itching. In particular, minoxidil contact dermatitis does not produce increase or alterations in the morphology of the scalp vessels or significant scalp scaling when evaluated with dermoscopy.

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The importance of proper vehicle selection in the detection of minoxidil sensitivity

Cited by 7 publications

References 0 publications

The Evaluation of Efficacy and Safety of Topical Saw Palmetto and Trichogen Veg Complex for the Treatment of Androgenetic Alopecia in Men

The Evaluation of Efficacy and Safety of Topical Saw Palmetto and Trichogen Veg Complex for the Treatment of Androgenetic Alopecia in Men

Sensitization to saw palmetto and minoxidil in separate topical extemporaneous treatments for androgenetic alopecia

Videodermoscopy does not enhance diagnosis of scalp contact dermatitis due to topical minoxidil

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