The Importance of Proper Vehicle Selection in the Detection of Minoxidil Sensitivity

Whitmore, S. Elizabeth

doi:10.1001/archderm.1992.01680150083011

Cited by 22 publications

(8 citation statements)

References 13 publications

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“…Lotions, creams, and gels with sulfacetamide, ketoconazole (129), tar or ciclopirox (130) are available. Some gels contain fl ammable vehicles; patients should avoid fi re, fl ame, or smoking during and immediately after application (136). Thus, gel formulations may be especially effective for seborrheic dermatitis.…”

Section: Gels Lotions Creamsmentioning

confidence: 99%

“…As mentioned earlier, there are two available formulations of minoxidil, 2% and 5% solutions. However, there was no reaction seen to propylene glycol (20% aq) or 2 % minoxidil tested in alcohol or petrolatum (136). This may explain why phase III clinical trials showed that the 5% solution had three times more adverse reactions than the 2% solution (135).…”

Section: Minoxidilmentioning

confidence: 99%

See 1 more Smart Citation

Hair and Scalp Diseases

McMichael¹,

Hordinsky²

2008

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International Standard Book Number-10: 1-57444-822-6 (Hardcover) International Standard Book This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequence of their use.No part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, Our thanks to Ralph, Jessica, and Jacob Thomas and Bob, Irene, Catherine, Alexander, and Kristina Kramarczuk for their help and support. Their understanding about the late nights at the computer, the many conference calls, and the missed family time was the key that allowed us to fi nish this endeavor. We could not have done it without you! -Amy J. McMichael Maria K. Hordinsky Downloaded from informahealthcare.com by Nyu Medical Center on 07/16/15 For personal use only. Downloaded from informahealthcare.com by Nyu Medical Center on 07/16/15 For personal use only. PrefaceOur goals were several in developing and editing Hair and Scalp Diseases: Medical, Surgical, and Cosmetic Treatments. First, we wanted to give the readers of our text a comprehensive view of treatment for each scalp and hair disorder. Rather than follow previous models, we strove to create the quintessential text on treatment of these disorders with a special concentration on ethnicity, hair type, and cultural haircare practices for each entity in a composite fashion. We wanted to impart widely the information that has been accumulated by specialists in the fi eld of hair and scalp disorders and to do so in a way that was easy to follow, practical, and complete. Finally, we strove to enumerate treatments that may go beyond accepted U.S. and international guidelines and incorporate off-label use of medications when data indicates this may be necessary. We charged our contributors with the challenge of approaching each hair disorder with a therapeutic ladder. The treatment of each disorder begins in the simplest form and becomes more complex, dependent upon patient response, cultural practices, and concomitant disease. We asked each author to create treatment plans that look beyond the best-described treatments to those that incorporate creative, thoughtful approaches to the management of the multitude of hair and scalp disorders that challenge dermatologists. While physicians must be savvy about product inserts for recommended dosage schedules, we asked our contributors to consider how practical and effective treatment may differ from package inserts or must be altered to allow for treatment of a wide range of patients with different hair types.We asked authors to report how the treatments that they chose worked, including mechanism of action, absorption characteristics, and general pharmacology of the agent or agents. We felt this was im...

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Section: Gels Lotions Creamsmentioning

confidence: 99%

Section: Minoxidilmentioning

confidence: 99%

Hair and Scalp Diseases

McMichael¹,

Hordinsky²

2008

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“…Normal volunteers present some advantages when the patient population is likely to have been previously exposed. In the vehicle experiments reviewed here, we note with Merck Index primary literature review articles such as Chemical Abstracts calculations from Hansh-Leo data laboratory determination -the greater the affinity of a vehicle for the allergen it contains, the less the percutaneous absorption of the vehicle should occur -patch testing is done with occlusion which may alter delivery from 0 to 10 x -importance of stating which patch was used, because of penetration differences -vehicles may affect immunocompetent cells as well as altering penetration Clinical aspects -crucial to document clinical relevance with a use test, as it gives additional weight in the operational definition of allergic contact dermatitis intellectual frustration (including some of our own studies) that interpretation difficulty was compounded by inadequate numbers of controls for irritancy (e.g., (10,17)). Few studies had adequate irritant controls.…”

Section: Sample Sizementioning

confidence: 99%

The role of vehicles in diagnostic patch testing

Tanglertsampan¹,

Maibach²

1993

Contact Dermatitis

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The correct selection of vehicles for patch testing is crucial in the evaluation of suspected allergic contact dermatitis. We reviewed the literature by using Grateful Med software for the years 1966-1992, utilizing the subjects "vehicles" and "allergic contact dermatitis" or "patch tests". Vehicles can influence bioavailability of the chemicals and subsequently percutaneous absorption or interaction with allergens. There are methodological problems in interpreting studies, such as sample size, percutaneous absorption and clinical aspects. Our judgement, partially validated by the literature, suggested that improved delivery systems (such as via vehicles) might significantly increase optimization, reliability and reproducibility of patch tests.Key words: allergic contact dermatitis; vehicles; patch testing technique; percutaneous penetration.© Munksgaard, 1993. Accepted for publication 30 Aprill993The proper vehicle for patching is crucial in the evaluation of suspected allergic contact dermatitis. Marzulli demonstrated the effect of vehicle selection on both induction and elicitation of allergy (1). Vehicles can influence the bioavailability of the chemicals and subsequently percutaneous absorption or interaction with allergens. Therefore, the use of an appropriate vehicle is an important aspect of patch testing.

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“…Patch testing in cases with suspected minoxidil allergic contact dermatitis should include testing with minoxidil in propylene glycol because it has been found to be the allergen responsible in many cases 9 . In these patients an alternative solvent may be used 10 . Sensitization to the active ingredient minoxidil is extremely rare, but does exclude these patients from any further treatment containing minoxidil 9 …”

mentioning

confidence: 99%