The importance of mold sensitivity in nonallergic rhinitis patients

Demirtürk, Mustafa; Gelincik, Aslı; Ulusan, Murat; Ertek, Belkıs; Büyüköztürk, Suna; Çolakoğlu, Bahattin

doi:10.1002/alr.21731

Cited by 7 publications

(5 citation statements)

References 33 publications

(45 reference statements)

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“…49,56 While most patients with LAR are monosensitized, most commonly to dust mite, up to 37% are polysensitized to seasonal and/or perennial allergens. 46,49,57 Of particular interest is a significantly lower incidence (2.7%) of animal dander sensitization in patients with LAR compared with in patients with AR (31%). 49 The majority of adult patients with LAR have moderate/severe, persistent, and perennial symptoms, with common comorbidities of conjunctivitis (50%-65%) and asthma (18%-47%).…”

Section: Classification Of Ar: Severity Frequency and Environmentalmentioning

confidence: 99%

Rhinitis 2020: A practice parameter update

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2020

Journal of Allergy and Clinical Immunology

164

171

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Section: Classification Of Ar: Severity Frequency and Environmentalmentioning

confidence: 99%

Rhinitis 2020: A practice parameter update

Parameters

Contributors

2020

Journal of Allergy and Clinical Immunology

164

171

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“…Molds may also be responsible for NAR, where there is a local reaction to mycotoxins and other irritating substances. 75 Longitudinal epidemiological data between 2006 and 2017 suggested a cause-andeffect relationship as well as an association between exposure to molds and development and exacerbation of asthma in children, and AR, respectively. 76 Using objective measures such as aeroallergen wheal area for detection of early sensitization in children, and nasal eosinophils as a marker of allergic eosinophilic rhinitis (AER), Penicillium wheal area (and sensitization) strongly correlated with AER in children at age 4, but not at age one or two.…”

Section: Moldsmentioning

confidence: 99%

International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants

Naclerio¹,

Ansotegui²,

Bousquet³

et al. 2020

World Allergy Organization Journal

111

112

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Allergic rhinitis affects the quality of life of millions of people worldwide. Air pollution not only causes morbidity, but nearly 3 million people per year die from unhealthy indoor air exposure. Furthermore, allergic rhinitis and air pollution interact. This report summarizes the discussion of an International Expert Consensus on the management of allergic rhinitis aggravated by air pollution. The report begins with a review of indoor and outdoor air pollutants followed by epidemiologic evidence showing the impact of air pollution and climate change on the upper airway and allergic rhinitis. Mechanisms, particularly oxidative stress, potentially explaining the interactions between air pollution and allergic rhinitis are discussed. Treatment for the management of allergic rhinitis aggravated by air pollution primarily involves treating allergic rhinitis by guidelines and reducing exposure to pollutants. Fexofenadine a non-sedating oral antihistamine improves AR symptoms aggravated by air pollution. However, more efficacy studies on other pharmacological therapy of coexisting AR and air pollution are currently lacking.

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“…Bu çalışmalarda, önceden non-allerjik rinit tanısı ile izlenen hastaların nazal mukozalarında ev içi ve ev dışı küf mantarlarına spesifik IgE yanıtı olduğu gösterilmiştir. Alerjik rinitin AH gelişiminde önemli bir risk faktörü olduğu düşü-nüldüğünde, invitro ve in vivo alerji testleri ile duyarlılık saptanmayan "nonallerjik" AH'li çocukların aslında lokal AR olduğu ve saptanamasa bile küf mantarı duyarlılığının düşünüldüğünden daha sık olduğu ileri sürülmüştür (13,14) . Sonuç olarak, lokal IgE yanıtının araştırıldığı bir çalışmada, adenoid dokusunda Alternaria ve Aspergillus için sIgE'nin belirgin olarak artmış olduğu saptanmıştır (6) .…”

Section: Discussionunclassified

Does mold sensitivity cause adenoid hypertrophy in children?

Berksoy¹,

Asilsoy²,

Bağ³

et al. 2017

BUCH

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ÖZAmaç: Adenoid hipertrofisine kronik adenoid infeksiyonları ve alerjik inflamasyon yol açmaktadır. Alerjik inflamasyon dolayısıyla alerjik rinitin önemli nedenlerinden biri başta ev tozu ve küf mantarı olmak üzere ev içi alerjenlerdir. Bu çalışmada, adenoid hipertrofisi gelişen çocuklarda küf mantarı duyarlılığının araştırılması amaçlan-mıştır. Yöntem: Dr. Behçet Uz Çocuk Hastanesi Çocuk Alerji Polikliniğine başvuranlardan öyküsünde adenoidektomi uygulanmış olan 34 hasta çalışmaya alınmıştır. Hastalara önce yakınmalarını ve risk faktörlerini sorgulayan bir anket yapılmış, daha sonra serum total IgE, serum sIgE(mold) düzeyleri ve alerji deri prick test istenmiştir. Bulgular: Çalışmaya alınan hastaların yaşları 5 ile 9 yaş arasında değişmekte olup, 7 (%21)'si kız, 27 (%79)'si erkektir. En sık yakınma; burun tıkanıklığı (%88), horlama (%82) ve terleme (%76), en sık saptanan risk faktörü ise, çevresel sigara dumanı maruziyeti (%52), klima ile ısınma (%38) ve soğuk buhar cihazı kullanımı (%32) olarak bulunmuştur. Hastaların %12'sinde sIgE (Alternaria) pozitifliği, %18'inde alerji deri testinde küf mantarı (Alternaria) duyarlılığı saptanmıştır. Sonuç: Adenoid hipertrofisi olan çocuklarda küf mantarı duyarlılığı araştırılmalı-dır.Anahtar kelimeler: Adenoid, alerji, çocuk, küf mantarı ABSTRACT Objective: Chronic adenoid infections, and allergic inflammation lead to development of adenoid hypertrophy. One of the major causes of allergic rhinitis due to allergic inflammation is indoor allergens, mainly house dust mites and molds. In this study, it was aimed to investigate the frequency of mold fungi sensitivity in the etiology of allergic rhinitis caused by adenoid hypertrophy in children. Methods: Among the patients who had been admitted to Pediatric Allergy Outpatient Clinic of Dr. Behçet uz Children Hospital, 34 cases with adenoidectomy were recruited. First, a questionarre including the risk factors and the symptoms were applied to the patients. Later, total eosinophil counts, serum total IgE and spesific IgE (m6) levels of the patients were examined and finally skin prick test was applied. Results: The age of the patients included in the study varied between five and nine years, seven (21%) of the patients were female and 27 (79%) of them were male. The the most frequent symptoms were nasal congestion (88%), snoring (82%), sweating (76%); the most frequently identified risk factors were enviromental smoke exposure (52%), use of air conditioning for warming (38%), and cold steam device (32%) respectively. Specific IgE (Alternaria) positivity was detected in 12% of the patients and mold sensitivity (Alternaria) in allergy skin test was detected in 18% of the patients. Conclusion: In children with adenoid hypertrophy,mold sensitivity should be investigated.

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The importance of mold sensitivity in nonallergic rhinitis patients

Cited by 7 publications

References 33 publications

Rhinitis 2020: A practice parameter update

Rhinitis 2020: A practice parameter update

International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants

Does mold sensitivity cause adenoid hypertrophy in children?

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