The importance of microvessel density in predicting cancer progression in patients with penile squamous cell carcinoma

Arora, Arushi; Bansal, Ankur

doi:10.1007/s11255-017-1565-3

Int Urol Nephrol

2017

DOI: 10.1007/s11255-017-1565-3

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The importance of microvessel density in predicting cancer progression in patients with penile squamous cell carcinoma

Arushi Arora

Ankur Bansal²

Abstract: Higher intratumoral and peritumoral MVD predicts cancer progression in patients with PSCC. Patients with an intratumoral MVD of 54 and peritumoral MVD of 61 have lymph node metastasis with a high sensitivity and specificity. The overall 5-year survival of patients is poor in high intratumoral or peritumoral MVD.

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2022

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Clinical and Novel Biomarkers in Penile Carcinoma: A Prospective Review

Pekarek

Ortega

Fraile-Martínez

et al. 2022

JPM

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Penile carcinoma is a rare urological neoplasia in men compared to other more common tumors, such as prostate, kidney, or bladder tumors. However, this neoplasm continues to affect a large number of patients worldwide, with developing countries presenting the highest incidence and mortality rates. Important risk factors such as the human papilloma virus, a factor affecting a large number of patients, have been described; however, few studies have evaluated screening programs in populations at risk for this disease, which severely affects the quality of life of older men. The management of these patients is usually complex, requiring surgical interventions that are not without risk and that have a great impact on the functionality of the male reproductive system. In addition, in cases of disseminated disease or with significant locoregional involvement, patients are evaluated by multidisciplinary oncological committees that can adjust the application of aggressive neoadjuvant or adjuvant chemotherapy on numerous occasions without clear improvement in survival. Chemotherapy regimens are usually aggressive, and unlike in other urological neoplasms, few advances have been made in the use of immunotherapy in these patients. The study of serological and histological biomarkers may help to better understand the underlying pathophysiology of these tumors and select patients who have a higher risk of metastatic progression. Similarly, the analysis of molecular markers will improve the availability of targeted therapies for the management of patients with disseminated disease that would benefit prognosis. Therefore, the purpose of this article is to summarize the main advances that have occurred in the development of serological and histological markers and their therapeutic implications in patients diagnosed with penile carcinoma, explaining the limitations that have been observed and analyzing future perspectives in the management of this disease.

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Clinical and Novel Biomarkers in Penile Carcinoma: A Prospective Review

Pekarek

Ortega

Fraile-Martínez

et al. 2022

JPM

View full text Add to dashboard Cite

show abstract

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The importance of microvessel density in predicting cancer progression in patients with penile squamous cell carcinoma

Cited by 1 publication

References 26 publications

Clinical and Novel Biomarkers in Penile Carcinoma: A Prospective Review

Clinical and Novel Biomarkers in Penile Carcinoma: A Prospective Review

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