The importance of metabolic factors for the increasing prevalence of fatty liver in Shanghai factory workers

Fan, Jian‐Gao; Li, Feng; Cai, Xiaobo; Peng, Yongde; Ao, Qing-Hong; Gao, Yan

doi:10.1111/j.1440-1746.2007.04892.x

Cited by 37 publications

(63 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This disparity would likely be largely due to differences between different population stocks in addition to differences in the specifics of diagnostic criteria for such a NAFLD. This is one of the possible reasons that the prevalence of NAFLD in this elderly agricultural and fishing population (27.2%) was lower than the corresponding figure presented in a previous occupational population-based study conducted in Chinese populations [4,9,12]. Our study demonstrated NAFLD to be a disease of elderly age group with a mean age at presentation being 67 years.…”

Section: Discussion Prevalence and Cardiovascular Factors For The Devcontrasting

confidence: 48%

“…Although NAFLD has been demonstrated to be present in several occupational populations and has been shown to be responsible for more than one third of patients with asymptomatic disorder, little is known about the baseline clinical and biochemical profiles of elderly sub-population [4,9,12]. The prevalence of a NAFLD amongst different screened populations appears to vary according to the results of different studies conducted in different countries [13][14][15].…”

Section: Discussion Prevalence and Cardiovascular Factors For The Devmentioning

confidence: 99%

See 1 more Smart Citation

Clinical epidemiology of prevalence and cardiovascular risk factors of nonalcoholic fatty liver disease among the elderly agricultural and fishing population in Taiwan

Sun¹,

Chen²,

Shen³

et al. 2017

Geriatr Med Care

View full text Add to dashboard Cite

Purpose: To explore any gender-related differences in prevalence of and cardiovascular risk factors related to non-alcoholic fatty liver disease (NAFLD) amongst the elderly agricultural and fishing population in Taipei, Taiwan. Methods:The study participants were conducted with a total of 6,511 (3,971 males and 2,540 females) healthy elderly subjects voluntarily admitted to a teaching hospital for a physical check-up in 2010. Blood samples and real-time ultrasound-proved fatty liver sonography results were collected. Results:The prevalence of NAFLD for this elderly study population was found to be 27.2%, the proportion revealing a statistically significant decrease with increasing population age (p<0.001). Females showed a greater prevalence of NAFLD than did males (34.1% vs. 22.7%, p-value forχ 2 -test <0.001). Using multiple logistic regression analysis, in addition to female gender, a younger age, higher ALT, higher BMI, presence of hypercholesterolemia, hypertriglyceridemia, lower HDL, and higher fasting plasma glucose were the significant factors associated with NAFLD. Gender-related differences as regards associated factors were also revealed. For females, hypertension (OR=1.18, 95%CI: 1.00-1.40), and lower HDL (OR=1.31, 95%CI: 1.10-1.56) were significantly related to NAFLD but these were not so for males. Conclusion:Several gender-related differences were noted pertaining to the prevalence of and relationship between hypertension, lower HDL, and NAFLD in this occupational elderly study population.

show abstract

Section: Discussion Prevalence and Cardiovascular Factors For The Devcontrasting

confidence: 48%

Section: Discussion Prevalence and Cardiovascular Factors For The Devmentioning

confidence: 99%

Clinical epidemiology of prevalence and cardiovascular risk factors of nonalcoholic fatty liver disease among the elderly agricultural and fishing population in Taiwan

Sun¹,

Chen²,

Shen³

et al. 2017

Geriatr Med Care

View full text Add to dashboard Cite

show abstract

“…The majority of subjects were light to moderate alcohol drinkers, and the average daily alcohol consumption even in the excessive drinkers was less than 60 g/d in the present study. This might be related to the different alcohol drinking culture backgrounds worldwide and the universal concern about the overall health among Shanghai adults [16,18,21] . The low prevalence of current alcohol drinking is consequently consistent with the uncommon alcoholic fatty liver (0.79%).…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and metabolic syndrome among Shanghai adults: A randomized multistage stratified cluster sampling investigation

Fan

Cai²,

Lui³

et al. 2008

WJG

Self Cite

View full text Add to dashboard Cite

AIM:To examine the relations of alcohol consumption to the prevalence of metabolic syndrome in Shanghai adults. METHODS:We performed a cross-sectional analysis of data from the randomized multistage stratified cluster sampling of Shanghai adults, who were evaluated for alcohol consumption and each component of metabolic syndrome, using the adapted U.S. National Cholesterol Education Program criteria. Current alcohol consumption was defined as more than once of alcohol drinking per month. RESULTS:The study population consisted of 3953 participants (1524 men) with a mean age of 54.3 ± 12.1 years. Among them, 448 subjects (11.3%) were current alcohol drinkers, including 405 males and 43 females. After adjustment for age and sex, the prevalence of current alcohol drinking and metabolic syndrome in the general population of Shanghai was 13.0% and 15.3%, respectively. Compared with non drinkers, the prevalence of hypertriglyceridemia and hypertension was higher while the prevalence of abdominal obesity, low serum high-density-lipoprotein cholesterol (HDL-C) and diabetes mellitus was lower in subjects who consumed alcohol twice or more per month, with a trend toward reducing the prevalence of metabolic syndrome. Among the current alcohol drinkers, systolic blood pressure, HDL-C, fasting plasma glucose, and prevalence of hypertriglyceridemia tended to increase with increased alcohol consumption. However, low-density-lipoprotein cholesterol concentration, prevalence of abdominal obesity, low serum HDL-C and metabolic syndrome showed the tendency to decrease. Moreover, these statistically significant differences were independent of gender and age. CONCLUSION:Current alcohol consumption is associated with a lower prevalence of metabolic syndrome irrespective of alcohol intake (g/d), and has a favorable influence on HDL-C, waist circumference, and possible diabetes mellitus. However, alcohol intake increases the likelihood of hypertension, hypertriglyceridemia and hyperglycemia. The clinical significance of these findings needs further investigation.

show abstract

“…4,[72][73][74] Similarly, only 15% of Chinese patients with NAFLD have diabetes at presentation. 20 Diabetes was seen in only 4.2% and 4.8% of males and 5.8% and11.6% of females with steatosis and NASH, respectively, in Korea. 75 This is in contrast to the Western studies where the prevalence of diabetes was 30-60% in patients with NAFLD.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

“…18 Similar high prevalence of NAFLD in obese population has been shown in Asia, ranging from 50% to 80% in Japan, 70% to 80% in China, 10% to 50% in Korea, and 47% in Indonesia. 2,[19][20][21] One study from Taiwan in morbidly obese patients undergoing bariatric surgery found the prevalence of NASH to be as high as 80%. 22 …”

Section: High-risk Populationsmentioning

confidence: 99%

Non-alcoholic Fatty Liver Disease: East Versus West

Agrawal

Duseja

2012

Journal of Clinical and Experimental Hepatology

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is an important cause of liver disease worldwide with prevalence ranging from 10% to 30% in various countries. It has become an important cause of unexplained rise in transaminases, cryptogenic cirrhosis, and cryptogenic hepatocellular carcinoma. Pathogenesis is related to obesity, insulin resistance, oxidative stress, lipotoxicity, and resultant inflammation in the liver progressing to fibrosis. Pharmacological treatment in patients with NAFLD is still evolving and the treatment of these patients rests upon lifestyle modification with diet and exercise being the cornerstones of therapy. While there are many similarities between patients with NAFLD from Asia and the West, there are certain features which make the patients with NAFLD from Asia stand apart. This review highlights the data on NAFLD from Asia comparing it with the data from the West. ( J CLIN EXP HEPATOL 2012;2:122-134)

show abstract

The importance of metabolic factors for the increasing prevalence of fatty liver in Shanghai factory workers

Abstract: The prevalence of FL increased rapidly over the study period with increased rates of obesity and metabolic disorders; FL is becoming a major cause of abnormal ALT levels in the specific population.

Cited by 37 publications

References 20 publications

Clinical epidemiology of prevalence and cardiovascular risk factors of nonalcoholic fatty liver disease among the elderly agricultural and fishing population in Taiwan

Clinical epidemiology of prevalence and cardiovascular risk factors of nonalcoholic fatty liver disease among the elderly agricultural and fishing population in Taiwan

Alcohol consumption and metabolic syndrome among Shanghai adults: A randomized multistage stratified cluster sampling investigation

Non-alcoholic Fatty Liver Disease: East Versus West

Contact Info

Product

Resources

About