The Importance of Mental Health in the Mexican Public Health System

Pimentel, Landy

doi:10.29057/mjmr.v7i13.3794

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…22 Three areas emerge as priorities: prevention, hospitalization and social reintegration. 23 Mexico has one of the highest prevalence of mental disorders in the Americas (42.6%). 24 Fighting social stigma is essential since untreated mental health conditions lead to severe problems.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Treatment Resistant Depression: TRAL study sub analysis in a Mexican sample

Vázquez Hernández,

Alviso de la Serna,

Cruz

et al. 2023

Arch Neurocien

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Introduction: Epidemiology and burden of disease in LatAm is often scarce in psychiatric disorders. This is particularly relevant in Treatment-Resistant Depression (TRD), a burdensome condition in a significant proportion of Major depressive disorder (MDD) patients. The Treatment Resistant Depression in America Latina (TRAL) study set out to characterize the epidemiology and burden of TRD in MDD patients. This manuscript presents this characterization for the Mexico subset based on data from the TRAL study. Methods: A sample of 697 adult patients clinically diagnosed with MDD were recruited from 14 Mexican sites. Patients with relevant psychiatric comorbidities or enrolled in a clinical trial were excluded. Outcomes were mainly patient reported outcomes and assessment scales. Results: Prevalence of TRD in Mexico was 20.7%. Current suicidality is high in TRD patients (20.8%), as well as suicide behavior disorder (12.5%). SSRIs and SNRIs were the most common medications. Results from EQ-5D, SDS and WPAI show significant limitations for TRD patients in their everyday life. Discussion: Current results are aligned with available literature on treatment and prevalence of suicidality and suicide behavior disorder. The prevalence of TRD in MDD patients is high and presents a management challenge. Conclusions: The burden of TRD in Mexico is significant, although less severe than in other LatAm countries. Public health policies should improve diagnosis and availability of novel more efficacious therapies.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Treatment Resistant Depression: TRAL study sub analysis in a Mexican sample

Vázquez Hernández,

Alviso de la Serna,

Cruz

et al. 2023

Arch Neurocien

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Prospective analysis of a TRD cohort over a 1-year follow-up with standard of care in Mexico: results for depression severity, treatment response, disability and QoL from the multicenter, observational TRAL Study

Zambrano,

Vázquez Hernández,

Brandi Rigal

et al. 2023

Arch Neurocien

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Introduction: Based on TRAL Mexico subsample, clinical outcomes and Patient-Reported Outcomes (PROs) are reported here. Methods: From 697 patients with MDD recruited from 14 Mexican sites, 140 patients with diagnosis of TRD under standard of care (SOC) were included in the 1-year follow-up. Patients with relevant psychiatric comorbidities or active participation in a clinical trial were excluded. Outcomes were obtained from PROs and clinical assessment scales. Results: Patients were mostly female (82.6%), with a mean age of 47.6 years. Only 44.3% of the patients achieved a clinical response, and remission was around 37% (measured through MADRS). Results from PHQ-9, EQ-5D and SDS show significant symptoms and disability for TRD patients in their everyday life after 1-year of follow-up with SOC. Discussion: TRD patients showed a significant burden of the disease, as current SOC fails to deliver clinically meaningful results for the majority of the patients. Response, remission and relapse are far from the desired outcomes Conclusion: Mexico has undertaken relevant and meaningful strategies to improve mental health resources availability, but some unmet needs are yet to be addressed. All involved stakeholders should consider public policies to enhance clinical outcomes and availability of resources.

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The Importance of Mental Health in the Mexican Public Health System

Cited by 2 publications

References 3 publications

Prevalence of Treatment Resistant Depression: TRAL study sub analysis in a Mexican sample

Prevalence of Treatment Resistant Depression: TRAL study sub analysis in a Mexican sample

Prospective analysis of a TRD cohort over a 1-year follow-up with standard of care in Mexico: results for depression severity, treatment response, disability and QoL from the multicenter, observational TRAL Study

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