The Importance of HSPA-2 Expression in Laryngeal Squamous Cell Carcinomas

Abstract

Objective: Laryngeal Squamous Cell Carcinoma (LSCC) has high recurrence, metastasis and mortality rates, thus determining the markers related to prognosis and the methods that can be effective in its treatment are important. Studies have reported that HSPA-2 has an important role in tumor growth but there is a limited number of studies about LSCC. The aim of our study was to examine the relationship between HSPA-2 expression and clinicopathological parameters in LSCC. Material and Methods: HSPA-2 was studied on 57 cases who have been diagnosed with LSCC in the last 7 years. The connection between HSPA-2 expression and important prognostic parameters was investigated. Results: In all of the cases, positive immunoreactivity was determined with HSPA-2. A significant relationship was determined between the HSPA-2 expression and important prognostic parameters such as lymphovascular invasion, lymph nodule metastasis, the primary tumor, the TNM stage, and survival rates. Conclusion: Our study supports the link between high HSPA-2 expression levels and poor prognostic parameters. Therefore we think that HSPA-2 can be used as a prognostic marker in laryngeal cancer. Also, we think that HSPA-2 is important in early diagnosis due to its increased expression even in LSCC precursor conditions. In addition, we believe that treatment regimens based on inhibiting HSPA-2 expression in the early stage of LSCC will be effective.