The importance of gestational diabetes beyond pregnancy

Ramírez-Torres, María Aurora

doi:10.1111/nure.12070

Cited by 18 publications

(14 citation statements)

References 35 publications

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“…In order to prevent these adverse outcomes, such as T2D, it is imperative to understand the hormonal changes and altered glucose metabolism that are associated with the development of GDM during pregnancy [5]. GDM occurs when insulin receptors are not able to respond adequately to control blood sugar levels due to hormones produced in pregnancy, such as human placental lactogen, which impacts susceptible insulin receptors.…”

Section: Introductionmentioning

confidence: 99%

Primary prevention of gestational diabetes mellitus through nutritional factors: a systematic review

Donazar-Ezcurra

Burgo

Bes–Rastrollo

2017

BMC Pregnancy Childbirth

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BackgroundGestational diabetes mellitus (GDM), defined as any degree of glucose intolerance with onset during pregnancy, is increasing worldwide, mostly because obesity among women of reproductive age is continuously escalating. GDM is associated with adverse maternal and fetal outcomes. The aim of this article was to systematically review literature on the effectiveness of nutritional factors before or during pregnancy to prevent GDM.MethodsWe assessed the primary prevention of GDM through nutritional factors, as diet and supplements. We searched on PubMed, Cochrane Databases and ClinicalTrials.gov from inception to June 2016. Clinical trials and adjusted prospective cohort studies were included.ResultsEight clinical trials and twenty observational studies assessing the association between dietary factors and primary prevention of GDM were included. Furthermore, six clinical trials and two observational studies related to supplements were also added. Only two nutritional interventions were found to significantly reduce the incidence of GDM, besides the supplements. However, the observational studies showed that a higher adherence to a healthier dietary pattern can prevent the incidence of GDM, especially in high risk population before getting pregnant.ConclusionsThe results indicate that there may be some benefits of some nutritional factors to prevent GDM. However, better-designed studies are required to generate higher quality evidence. At the moment, no strong conclusions can be drawn with regard to the best intervention for the prevention of GDM.Electronic supplementary materialThe online version of this article (doi:10.1186/s12884-016-1205-4) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Primary prevention of gestational diabetes mellitus through nutritional factors: a systematic review

Donazar-Ezcurra

Burgo

Bes–Rastrollo

2017

BMC Pregnancy Childbirth

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“…Gestational diabetes mellitus (GDM) is the common cause of hyperglycaemia in pregnancy, accounting for about 90% of all diabetes during pregnancy . Usually, GDM resolves after the baby is born , nevertheless, it makes a woman prone to GDM in later pregnancies, and is associated with long‐term health risks to the mother as well as the child, such as predisposition to obesity, metabolic syndrome and diabetes later in life . It is also associated with maternal and perinatal outcomes such as pregnancy‐induced hypertension, pre‐eclampsia, antepartum haemorrhage, caesarean, preterm birth, birth trauma and congenital anomalies .…”

Section: Introductionmentioning

confidence: 99%

Gestational diabetes mellitus in sub‐Saharan Africa: systematic review and metaregression on prevalence and risk factors

Mwanri

Kinabo

Ramaiya

et al. 2015

Tropical Med Int Health

111

109

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Abstractobjective We systematically reviewed publications on prevalence and risk factors for gestational diabetes mellitus (GDM) in the 47 countries of sub-Saharan Africa.methods We conducted a systematic search in PUBMED and reviewed articles published until June 2014 and searched the references of retrieved articles. We explored sources of heterogeneity among prevalence proportions with metaregression analysis.results Of 1069 articles retrieved 22 studies were included. Half were from West Africa, specifically Nigeria, five from South Africa and six from East and Central Africa. There were differences in screening methods and diagnosis criteria used, even between studies carried out in the same country and same time period. Metaregression analysis indicated high heterogeneity among the studies (I 2 = 100, P < 0.001), which could not be sufficiently explained by study setting, population, diagnostic criteria or time trend, although we observed a relatively higher prevalence in studies carried out after 2000 (5.1% vs. 3.2%), when women at risk were selected (6.5% vs. 3.8%) and when more current diagnostic criteria were used (5.1% vs. 4.2%). Associations with risk factors were reported in six studies. Significant risk factors reported in more than one study were overweight and/ or obesity, family history for type 2 diabetes, previous stillbirth, previous macrosomic child and age >30 years.conclusions There are few studies on prevalence and risk factors for GDM in Sub-Saharan Africa and heterogeneity is high. Prevalence was up to about 14% when high-risk women were studied. Preventive actions should be taken to reduce the short-and long-term complications related to GDM in Sub-Saharan Africa.

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“…In Mexico, no nationwide prevalence has been reported for GDM due to the lack of both detection programs and a consensus diagnostic method. However, a recent study found a prevalence of 12.9% [ 2 ], compared to a T2D prevalence of 24.2% among individuals under 40 years old, both reported in 2012 [ 3 ]. Physiological similarities between T2D and GDM suggests that they could share a common genetic background.…”

Section: Introductionmentioning

confidence: 99%

Genetic Determinants for Gestational Diabetes Mellitus and Related Metabolic Traits in Mexican Women

et al. 2015

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Epidemiological and physiological similarities among Gestational Diabetes Mellitus (GDM) and Type 2 Diabetes (T2D) suggest that both diseases, share a common genetic background. T2D risk variants have been associated to GDM susceptibility. However, the genetic architecture of GDM is not yet completely understood. We analyzed 176 SNPs for 115 loci previously associated to T2D, GDM and body mass index (BMI), as well as a set of 118 Ancestry Informative Markers (AIMs), in 750 pregnant Mexican women. Association with GDM was found for two of the most frequently replicated T2D loci: a TCF7L2 haplotype (CTTC: rs7901695, rs4506565, rs7903146, rs12243326; P=2.16x10-06; OR=2.95) and a KCNQ1 haplotype (TTT: rs2237892, rs163184, rs2237897; P=1.98x10-05; OR=0.55). In addition, we found two loci associated to glycemic traits: CENTD2 (60’ OGTT glycemia: rs1552224, P=0.03727) and MTNR1B (HOMA B: rs1387153, P=0.05358). Remarkably, a major susceptibility SLC16A11 locus for T2D in Mexicans was not shown to play a role in GDM risk. The fact that two of the main T2D associated loci also contribute to the risk of developing GDM in Mexicans, confirm that both diseases share a common genetic background. However, lack of association with a Native American contribution T2D risk haplotype, SLC16A11, suggests that other genetic mechanisms may be in play for GDM.

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The importance of gestational diabetes beyond pregnancy

Cited by 18 publications

References 35 publications

Primary prevention of gestational diabetes mellitus through nutritional factors: a systematic review

Primary prevention of gestational diabetes mellitus through nutritional factors: a systematic review

Gestational diabetes mellitus in sub‐Saharan Africa: systematic review and metaregression on prevalence and risk factors

Genetic Determinants for Gestational Diabetes Mellitus and Related Metabolic Traits in Mexican Women

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