The importance of fertility preservation in cancer patients

Pacey, Allan; Eiser, Christine

doi:10.1586/14737140.2014.883283

Cited by 16 publications

(7 citation statements)

References 22 publications

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“…This corresponds to studies indicating that patients with a low level of education are less likely to make fertility preservation arrangements (Grover et al, 2016, Shnorhavorian et al, 2015. It may be necessary to provide more intensive counselling to patients with lower education levels (Pacey and Eiser, 2014).…”

Section: Discussionsupporting

confidence: 65%

Utilization of sperm cryopreservation in patients with testicular cancer

Menzel,

Richter,

Helke

et al. 2024

Preprint

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Purpose Since 2021, the German health insurance covers sperm cryopreservation, impacting pre-chemotherapy decisions. We assessed sperm cryopreservation utilization before 2021, when patients covered expenses.Methods Between 2011 and 2021, testicular cancer survivors (TCS) at our clinic completed a questionnaire, including EORTC QLQ-TC26, covering sperm cryopreservation, sociodemographic details, post-treatment births, and artificial insemination.Results After 5.7 ± 3.0 years, 279 participants (64%) responded to the questionnaire. Among them, 33% (91/279) testicular cancer survivors (TCS) chose sperm cryopreservation prior treatment, with 11% (10/91) using it for insemination. Conversely, 2% (3/188) without cryopreservation reported unfulfilled desire to have children. Univariate analysis showed TCS with cryopreservation were younger (30.6 ± 7.1 (35 (21–59)) vs. 42.4 ± 10.9 (48 (22–81)) years; p = 0.001), had a lower BMI (24.2 ± 3.3 vs. 26.6 ± 4.6 kg/m²; p = 0.009) and a lower Charlson Score (> 3: 36% vs. 60%; p < 0.001). Multivariate analysis revealed older age (≥ 37 years: OR 13.1 (5.5–31.2), p < 0.001) and lower education (middle school or less: OR 3.3 (1.6–6.9), p = 0.001) as independent factors associated with not undergoing cryopreservation. Regarding quality of life (EORTC QLQ-TC26), multivariate analysis identified a lower infertility anxiety score (OR 4.3 (2.0–9.0), p < 0.001) and higher age (≥ 44 years: OR 5.4 (2.6–11.3); p < 0.001) were predictors for absence of prior cryopreservation.Conclusions Age and education seem to impact the choice of undergoing paid sperm cryopreservation. Urologists should inform testicular cancer patients about costs and coverage. Importantly, the occurrence of unmet desires for parenthood is minimal among those who forego cryopreservation.

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Section: Discussionsupporting

confidence: 65%

Utilization of sperm cryopreservation in patients with testicular cancer

Menzel,

Richter,

Helke

et al. 2024

Preprint

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“…Infertility is one such consequence of the toxic effects of chemotherapy and radiotherapy. Its incidence depends on the specific cancer, the individual's age, gender, diagnosis, and treatment dose (Pacey & Eiser, ). The ability to retain reproductive potential is a significant concern for TYAs, not only in the UK but internationally (Anderson et al., ; Armuand, Wettergreen, Rodriguez‐Wallberg, & Lampic, ; Barlevy, Wangmo, Elgar, & Vardit, ; Ellis, Wakefield, McLoone, Robertson, & Cohn, ; Geue et al., ).…”

Section: Introductionmentioning

confidence: 99%

Nurses’ experiences of undertaking fertility‐related discussions with teenagers and young adults with cancer: An interpretive phenomenological analysis

Wright

Norton

Geary

2018

Journal of Advanced Nursing

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“…This corresponds to studies indicating that patients with a low level of education are less likely to make fertility preservation arrangements (Grover et al 2016 ; Shnorhavorian et al 2015 ). It may be necessary to provide more intensive counseling to patients with lower education levels (Pacey and Eiser 2014 ). Addressing information disparities and promoting clear communication on sperm freezing benefits is crucial, especially for those with lower education.…”

Section: Discussionmentioning

confidence: 99%

Utilization of sperm cryopreservation in patients with testicular cancer

Menzel,

Richter,

Helke

et al. 2024

J Cancer Res Clin Oncol

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Purpose We assessed factors that affect the utilization of sperm cryopreservation before 2021, when patients covered expenses, and the influence on quality of life. Methods Between 2011 and 2021, testicular cancer survivors (TCS) at our clinic completed a questionnaire, including EORTC QLQ-TC26, covering sperm cryopreservation, sociodemographic details, post-treatment births, and artificial insemination. Results After 5.7 ± 3.0 years, 279 participants (64%) responded to the questionnaire. Among them, 33% (91/279) of testicular cancer survivors chose sperm cryopreservation prior to treatment, with 11% (10/91) using it for insemination. Conversely, 2% (3/188) without cryopreservation reported unfulfilled desire to have children. Univariate analysis showed TCS with cryopreservation were younger (30.6 ± 7.1 (35 (21–59)) vs. 42.4 ± 10.9 (48 (22–81)) years; p = 0.001), had a lower BMI (24.2 ± 3.3 vs. 26.6 ± 4.6 kg/m2; p = 0.009) and a lower Charlson Score (> 3: 36% vs. 60%; p < 0.001). Multivariate analysis revealed older age (≥ 37 years: OR 13.1 (5.5–31.2), p < 0.001) and lower education (middle school or less: OR 3.3 (1.6–6.9), p = 0.001) as independent factors associated with not undergoing cryopreservation. Regarding quality of life, multivariate analysis identified a lower infertility anxiety score (OR 4.3 (2.0–9.0), p < 0.001) and higher age (≥ 44 years: OR 5.4 (2.6–11.3); p < 0.001) as predictors for the absence of prior cryopreservation. Conclusions Age and education seem to impact the choice of undergoing paid sperm cryopreservation. Urologists should inform testicular cancer patients about costs and coverage. Importantly, the occurrence of unmet desires for parenthood is minimal among those who forego cryopreservation.

show abstract

The importance of fertility preservation in cancer patients

Cited by 16 publications

References 22 publications

Utilization of sperm cryopreservation in patients with testicular cancer

Utilization of sperm cryopreservation in patients with testicular cancer

Nurses’ experiences of undertaking fertility‐related discussions with teenagers and young adults with cancer: An interpretive phenomenological analysis

Utilization of sperm cryopreservation in patients with testicular cancer

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