The Importance of Equilibrium Constant and Heterogeneity
Index on Anti-Rh(0)(D) Quantitation Using the Auto-Analyser

Gunson, H.H.; Phillips, P.K.; Stratton, F.

doi:10.1159/000465585

Cited by 1 publication

(1 citation statement)

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“…Since it has been shown that estimates of anti-D concentration made by AutoAnalyzer methods are appreciably affected by variations in equilibrium constants (Gunson et al, 1976), it should be pointed out that the figures given in Table I1 assume that equilibrium constants did not vary widely in the samples tested. Moreover, it should be mentioned that although the British Working Standard, which is defined in international units, was used, results have been expressed as pg anti-D assuming that the relationship between i.u.…”

Section: Discussionmentioning

confidence: 99%

Failure to Augment Primary Rh Immunization Using a Small Dose of ‘Passive’ IgG Anti‐Rh

Contreras

Mollison

1981

Br J Haematol

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The immune response to the i.v. injection of 1 ml of D-positive (ccDEE, presumably cDE/cDE) red cells was studied in 12 D-negative (ccddee) subjects who received a simultaneous i.m. injection of 5 microgram anti-D (the test group) and in a further 12 D-negative subjects who were not given anti-D (the control group). In all cases the red cells were labelled with 51Cr. Further injections of 1 ml of red cells were given at 7 and 12 months to subjects who had not made serologically detectable anti-D. In the test group the rate of clearance of the first injection of red cells was very variable, 99% of the cells being cleared in a period ranging from 3 to 20 d. Within 6-10 weeks of the first injection four subjects had produced anti-D; four more subjects produced anti-D after the second injection of red cells. In the control group Cr red cell survival following the first injection was normal in six cases and curtailed in the remaining six. Of the latter, four produced anti-D within 4-10 weeks of the first injection and two produced anti-D only after the second or third injection of red cells. Amongst the subjects who produced anti-D after the first injection of red cells antibody levels were lower in the test group than in the control group, indicating that the injection of 5 microgram of anti-D with 1 ml red cells had not augmented the immune response and might have partially suppressed it.

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Section: Discussionmentioning

confidence: 99%