The importance of early weight gain in the intrauterine growth and birth weight of twins

Luke, Barbara; Min, Sung-Joon; Gillespie, Brenda W.; Avni, Michal; Witter, Frank R.; Newman, Roger B.; Mauldin, Jill; Salman, Fawwaz A.; OʼSullivan, Mary J.

doi:10.1016/s0002-9378(98)70124-3

Cited by 57 publications

(35 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…11,26 This mechanism may not seem to be responsible for the association in twins, as intra-uterine growth in twins slows down in the last trimester of pregnancy. However, Luke et al 27 found that maternal weight gain early in pregnancy contributed significantly to birth weight in twins.…”

Section: Subcutaneous Fat and Fat Distributionmentioning

confidence: 99%

Birth weight and body composition in young adult men—a prospective twin study

et al. 2001

View full text Add to dashboard Cite

OBJECTIVES:To evaluate the association between birth weight and adult body composition in twins, controlling for maternal and genetic influences. DESIGN: Twins were randomly selected from the East Flanders Prospective Twin Survey, a population-based historic twin cohort. SUBJECTS: Male members of 229 twin pairs between 18 and 34 y of age who participated in the Prenatal Programming Twin Study. MEASUREMENTS: Adult body mass, height, BMI, lean body mass, sum of skinfolds and waist-to-hip-ratio. Lean body mass, sum of skinfolds and waist-to-hip-ratio were also adjusted for body mass. Intra-pair difference in adult anthropometric measures between the heaviest and the lightest twin at birth. RESULTS: Per kg increase in birth weight, body mass (4.2 kg), height (3.3 cm), lean body mass (3.1 kg) and to a lesser extent BMI (0.49 kg=m 2 ) increased, whereas waist-to-hip-ratio ( 7 1.4%) and sum of skinfolds ( 7 0.11 s.d.) decreased, when adjusted for body mass. In a pair-wise analysis, the heavier twin at birth was taller and heavier as an adult, but, when adjusted for body mass, he had a lower waist-to-hip-ratio, less subcutaneous fat, and more lean body mass, compared to his lighter sib. Intra-pair difference in body composition was associated with intra-pair birth weight difference in monozygotic and dizygotic twins. CONCLUSIONS: An adverse intra-uterine environment, as measured by birth weight, is associated with more subcutaneous and abdominal fat and less lean body mass in adulthood. This association is independent of maternal and genetic influences. However, we cannot exclude the existence of genes that act on both birth weight and adult body composition.

show abstract

Section: Subcutaneous Fat and Fat Distributionmentioning

confidence: 99%

Birth weight and body composition in young adult men—a prospective twin study

et al. 2001

View full text Add to dashboard Cite

show abstract

“…From the regression equations, the rate of maternal weight gain to 20 weeks gestation, between 20 and 28 weeks gestation, and between 28 weeks gestation and birth was predicted. These gestational periods have been shown in prior studies on weight gain in twin pregnancies to be more important for fetal growth, rather than traditional trimesters (Luke et al, 1997;Luke et al, 1998). Fetal growth was characterized as the rate of growth (grams per week) in each gestational interval (0 to 20 weeks, 20 to 28 weeks, and 28 weeks to birth).…”

Section: Study Variablesmentioning

confidence: 99%

“…Linear regression including quadratic terms with no intercept was found to fit the data well. In addition, the proportional upward bias in ultrasonographic estimated fetal weights near birth was corrected for, forcing the regression curve through the actual birthweight (Luke et al, 1998). Rates of fetal growth were calculated as the predicted gain in each gestational interval, with birthweight used as the last measurement.…”

Section: Study Variablesmentioning

confidence: 99%

The Hispanic Paradox in Twin Pregnancies

et al. 2005

Self Cite

View full text Add to dashboard Cite

“…Several studies have clearly established the importance of maternal weight gain before 20 weeks on twin birthweight (Luke et al, 1992;Luke et al, 1993;Luke et al, 1998). A low rate of gain (< 6 kg) before 24 weeks is significantly associated with poor fetal growth and higher morbidity (Luke et al, 1992;Luke et al, 1993;Luke et al, 1998).…”

Section: Weight Gainmentioning

confidence: 99%

Nutritional Management of Multiple Pregnancies

Roem¹

2003

Twin Res

View full text Add to dashboard Cite

The importance of early weight gain in the intrauterine growth and birth weight of twins

Cited by 57 publications

References 16 publications

Birth weight and body composition in young adult men—a prospective twin study

Birth weight and body composition in young adult men—a prospective twin study

The Hispanic Paradox in Twin Pregnancies

Nutritional Management of Multiple Pregnancies

Contact Info

Product

Resources

About