The importance of early detection of calcifications associated with breast cancer in screening

Abstract

Purpose The aim of this study was to assess how often women with undetected calcifications in prior screening mammograms are subsequently diagnosed with invasive cancer. Methods From a screening cohort of 63,895 women, exams were collected from 59,690 women without any abnormalities, 744 women with a screen-detected cancer and a prior negative exam, 781 women with a false positive exam based on calcifications, and 413 women with an interval cancer. A radiologist identified cancer-related calcifications, selected by a computer-aided detection system, on mammograms taken prior to screen-detected or interval cancer diagnoses. Using this ground truth and the pathology reports, the sensitivity for calcification detection and the proportion of lesions with visible calcifications that developed into invasive cancer were determined. Results The screening sensitivity for calcifications was 45.5%, at a specificity of 99.5%. A total of 68.4% ( n = 177) of cancer-related calcifications that could have been detected earlier were associated with invasive cancer when diagnosed. Conclusions Screening sensitivity for detection of malignant calcifications is low. Improving the detection of these early signs of cancer is important, because the majority of lesions with detectable calcifications that are not recalled immediately but detected as interval cancer or in the next screening round are invasive at the time of diagnosis.

Fluorescent Arylphosphonic Acids: Synergic Interactions between Bone and the Fluorescent Core

“…[7a] Detecting and monitoring increased calcification can be av aluable early indication of breast cancer. [8] Conversely,m onitoring the decrease in mineralization can be usefulf or assessing osteoporosis. [9] In addition, evidencei s emerging that HAP deposition mayp lay ar ole in the development and progression of age-related maculard egeneration in the retina and neurodegenerationi nt he brain.…”

DNA methylation landscape of triple-negative ductal carcinoma in situ (DCIS) progressing to the invasive stage in canine breast cancer

“…www.nature.com/scientificreports www.nature.com/scientificreports/ of breast cancer calcification via mammography as part of breast cancer diagnoses 9,10 . However, Kojima and collegues reported that abnormal breast calcifications were only detected in 22% of TN-DCIS compared to 59-72% of other types of DCIS cases, emphazising the challenge associated with detecting this specific breast cancer subtype during its non-invasive term 7 .…”

Recuperación de información por contenido orientada a la clasificación de grupos de microcalcificaciones en mamografías - Protocam

“…De acuerdo con lo estipulado con el PDSP existe una proporción de los casos de mortalidad, morbilidad y discapacidad que pueden clasificarse como evitables teniendo en cuenta la existencia de los servicios de salud y la tecnología necesaria, de modo que su presencia significa fallas en el proceso de atención. La gran mayoría de cánceres no palpables detectados a partir de calcificaciones son DCIS, de los cuales menos del 20 % son de bajo grado, considerados generalmente como sobrediagnóstico, ya que no impacta la reducción de la mortalidad de los pacientes que lo sufren (Mordang et al, 2018). Sin embargo, en una mamografía categorizada como BI-RADS 3 no es posible para un radiólogo distinguir entre calcificaciones asociadas a un DCIS de bajo grado y formas más agresivas del mismo (grado II o III), que deberían ser detectadas lo más pronto posible (Bijker et al,…”