The Importance of Detecting Regulatory T Cells in Neonatal Sepsis

Abstract

can be defined as the fact that T cells do not proliferate under the stimulation of antigen and do not produce IL-2. Incompetence of T cells mediates immunosuppression. Inhibition refers to an active, immunomodulatory process that is mediated by regulatory T cells and that can be adoptively transferred. A large amount of research evidence indicates: Incompetence [7]. These cells and Tregs are the same cells at different stages of differentiation, that is, the incompetent cells are precursor cells of Tregs.CD4 + CD25 + CD127-Treg is the most important group. These Tregs are a typical subset of lymphocytes showing immune suppressive function, which selectively expressing molecular mark like CD25 (IL-2 receptor a), FOXP3, CTL4 (Cytotoxic T -Lymphocyte Antigen 4), LAE3 (Lymphocyte activating factor 3), TNFR (tumor necrosis factor receptor) and chemokine receptor 4,6,7,8,10. FOXP3 is specific marker of Tregs [8,9]. FOXP3 can activates the inhibiting function of CD4+ T cells which is important for differentiation and maturity of Tregs. They influence the immune balance by direct contacting with immune cells or secreting cytokines like IL-10, TGF-β [10]. They involve in various aspects of innate immune and adaptive immune like inhibiting CD4+ and CD8+ T cells functions, mediating lymphocyte differentiating from Th1 to Th2 and inducing lymphocytes apoptosis [11,12]. These Tregs also have effect on neutrophil and mononuclear macrophage to down-regulate their phagocytosis function [13]. When the host infected, the proportion of Treg will increase and results in immunosuppression [14]. The defect of Tregs will cause the severe hyperplasia of lymphoid tissue and hyperimmune activation. The important immune cells, like CD8 + and APCs (antigen presenting cell), Short reviewCheck for updates