The importance of comparative oncology in translational medicine

Riccardo, Federica; Aurisicchio, Luigi; Impellizeri, Joseph A.; Cavallo, Federica

doi:10.1007/s00262-014-1645-5

Cited by 37 publications

(42 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, the long history of dogs in biomedical research, their strong anatomical and physiological similarities to humans and the high number of pet dogs that are diagnosed with cancer and managed therapeutically, make these companion animals an attractive comparative model. Canine tumors mimic the progression of human malignancies better than any other pre-clinical model available so far since they grow over long periods of time following the natural evolution of human tumors, give rise to recurrences and metastases, and provide similar response to conventional therapies [9, 65, 66]. As a result, the study of spontaneous tumors developing in dogs as models for human malignancies is a priceless translational tool for accelerating the development of novel immunotherapeutic strategies with a substantial impact on the management of both canine and human oncological patients.…”

Section: Cspg4 Oncoantigen: a New Star On The Stage Of Comparative Onmentioning

confidence: 99%

“…As a result, the study of spontaneous tumors developing in dogs as models for human malignancies is a priceless translational tool for accelerating the development of novel immunotherapeutic strategies with a substantial impact on the management of both canine and human oncological patients. Several canine tumors are “under the microscope” of comparative oncology for their translational relevance; among them there are lymphosarcomas, mammary carcinomas, melanomas and osteosarcomas [9, 67–70]. …”

Section: Cspg4 Oncoantigen: a New Star On The Stage Of Comparative Onmentioning

confidence: 99%

“…Therefore, in 2003 the National Cancer Institute’s Center for Cancer Research introduced the Comparative Oncology Program in order to foster the study of naturally occurring cancer in pet animals as models of human tumors [8, 9]. A European initiative with a similar purpose—the LUPA project—has also recently been launched [10].…”

Section: Introductionmentioning

confidence: 99%

“…A European initiative with a similar purpose—the LUPA project—has also recently been launched [10]. The aim of comparative oncology is to integrate the naturally occurring cancers seen in veterinary patients into a more general study of cancer biology and therapy, to benefit both veterinary and human oncological patients [8, 9]. …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

CSPG4: a prototype oncoantigen for translational immunotherapy studies

et al. 2017

Self Cite

View full text Add to dashboard Cite

Thanks to striking progress in both the understanding of anti-tumor immune response and the characterization of several tumor associated antigens (TAA), a more rational design and more sophisticated strategies for anti-tumor vaccination have been possible. However, the effectiveness of cancer vaccines in clinical trial is still partial, indicating that additional studies are needed to optimize their design and their pre-clinical testing. Indeed, anti-tumor vaccination success relies on the choice of the best TAA to be targeted and on the translational power of the pre-clinical model used to assess its efficacy. The chondroitin sulfate proteoglycan-4 (CSPG4) is a cell surface proteoglycan overexpressed in a huge range of human and canine neoplastic lesions by tumor cells, tumor microenvironment and cancer initiating cells. CSPG4 plays a central role in the oncogenic pathways required for malignant progression and metastatization. Thanks to these features and to its poor expression in adult healthy tissues, CSPG4 represents an ideal oncoantigen and thus an attractive target for anti-tumor immunotherapy. In this review we explore the potential of CSPG4 immune-targeting. Moreover, since it has been clearly demonstrated that spontaneous canine tumors mimic the progression of human malignancies better than any other pre-clinical model available so far, we reported also our results indicating that CSPG4 DNA vaccination is safe and effective in significantly increasing the survival of canine melanoma patients. Therefore, anti-CSPG4 vaccination strategy could have a substantial impact for the treatment of the wider population of spontaneous CSPG4-positive tumor affected dogs with a priceless translational value and a revolutionary implication for human oncological patients.

show abstract

Section: Cspg4 Oncoantigen: a New Star On The Stage Of Comparative Onmentioning

confidence: 99%

Section: Cspg4 Oncoantigen: a New Star On The Stage Of Comparative Onmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

CSPG4: a prototype oncoantigen for translational immunotherapy studies

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Finally, cancer may soon become the leading cause of death in companion animals, as a result of increased life span. It has been observed that the same cancer types often develop in both humans and companion animals [46]. The development of novel treatment strategies and personalized treatments for tumors in pets, using organoid technology, will, therefore, mutually benefit the human and veterinary fields.…”

Section: Organoids In Animalsmentioning

confidence: 99%

Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals

Nantasanti

Bruin

Rothuizen

et al. 2016

Stem Cells Translational Medicine

View full text Add to dashboard Cite

Organoids are three-dimensional culture systems in which adult stem cells and their progeny grow and represent the native physiology of the cells in vivo. Organoids have been successfully derived from several organ systems in both animal models and human patients. Organoids have been used for fundamental research, disease modeling, drug testing, and transplantation. In this review, we summarize the applications of liver-derived organoids and discuss their potential. It is likely that organoids will provide an invaluable tool to unravel disease mechanisms, design novel (personalized) treatment strategies, and generate autologous stem cells for gene editing and transplantation purposes. STEM CELLS TRANSLATIONAL MEDICINE 2016;5:325-330 SIGNIFICANCEOrganoids derived from the liver have hepatocellular differentiation potential and can be an unlimited source for hepatocytes for application in in vitro toxicology testing and for transplantation purposes as an alternative to orthotopic liver transplantation. The in vitro representation of the native physiology and epigenetic background of the adult liver stem cells makes the organoid technology an excellent tool to study and model liver diseases, for drug screening, and for the design of personalized treatments. This review summarizes the applications of liver organoids and discusses their potential in the study and modeling of liver diseases, and in the development and testing of novel drugs.

show abstract

Wild animals as an underused treasure trove for studying the genetics of cancer

Sepp

Giraudeau

2022

BioEssays

View full text Add to dashboard Cite

Recent years have seen an emergence of the field of comparative cancer genomics. However, the advancements in this field are held back by the hesitation to use knowledge obtained from human studies to study cancer in other animals, and vice versa. Since cancer is an ancient disease that arose with multicellularity, oncogenes and tumour‐suppressor genes are amongst the oldest gene classes, shared by most animal species. Acknowledging that other animals are, in terms of cancer genetics, ecology, and evolution, rather similar to humans, creates huge potential for advancing the fields of human and animal oncology, but also biodiversity conservation. Also see the video abstract here: https://youtu.be/UFqyMx5HETY

show abstract

The importance of comparative oncology in translational medicine

Cited by 37 publications

References 103 publications

CSPG4: a prototype oncoantigen for translational immunotherapy studies

CSPG4: a prototype oncoantigen for translational immunotherapy studies

Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals

Wild animals as an underused treasure trove for studying the genetics of cancer

Contact Info

Product

Resources

About