The Importance of Cancer Biobanks in Low- and Middle-Income Countries

Cheong, Io Hong; Kozlakidis, Zisis

doi:10.1007/978-3-030-87637-1_21

Cited by 1 publication

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We created two versions of PURE frailty, adapting previous work that operationalised frailty using the assessments available in the PURE study 18 . Global frailty was defined as the presence of two or three of: unintentional weight-loss, weakness and low physical activity levels, where weakness was considered a handgrip strength below the lowest cohort-wide quintile for BMI and sex; and low physical activity was considered an activity level below the lowest cohort-wide quintile for each sex.…”

Section: Methodsmentioning

confidence: 99%

“…17 We created two versions of PURE frailty, adapting previous work that operationalised frailty using the assessments available in the PURE study. 18 Global frailty was defined as the presence of two or three of: unintentional weight-loss, weakness and low physical activity levels, where weakness was considered a handgrip strength below the lowest cohort-wide quintile for BMI and sex; and low physical activity was considered an activity level below the lowest cohort-wide quintile for each sex. Regional frailty was also defined as the presence of two or three of: unintentional weight-loss, weakness and low physical activity levels, but in contrast to global frailty, weakness was Open access considered a handgrip strength below the lowest regionspecific quintile for BMI and sex; and low physical activity was considered activity levels below the lowest regionspecific quintile for sex.…”

Section: Development Of Frailty Classificationsmentioning

confidence: 99%

See 1 more Smart Citation

How regional versus global thresholds for physical activity and grip strength influence physical frailty prevalence and mortality estimates in PURE: a prospective multinational cohort study of community-dwelling adults

et al. 2023

View full text Add to dashboard Cite

ObjectivesHandgrip strength and physical activity are commonly used to evaluate physical frailty; however, their distribution varies worldwide. The thresholds that identify frail individuals have been established in high-income countries but not in low-income and middle-income countries. We created two adaptations of physical frailty to study how global versus regional thresholds for handgrip strength and physical activity affect frailty prevalence and its association with mortality in a multinational population.Design, setting and participantsOur sample included 137 499 adults aged 35–70 years (median age: 61 years, 60% women) from Population Urban Rural Epidemiology Studies community-dwelling prospective cohort across 25 countries, covering the following geographical regions: China, South Asia, Southeast Asia, Africa, Russia and Central Asia, North America/Europe, Middle East and South America.Primary and secondary outcome measuresWe measured and compared frailty prevalence and time to all-cause mortality for two adaptations of frailty.ResultsOverall frailty prevalence was 5.6% usingglobal frailtyand 5.8% usingregional frailty. Global frailty prevalence ranged from 2.4% (North America/Europe) to 20.1% (Africa), while regional frailty ranged from 4.1% (Russia/Central Asia) to 8.8% (Middle East). The HRs for all-cause mortality (median follow-up of 9 years) were 2.42 (95% CI: 2.25 to 2.60) and 1.91 (95% CI: 1.77 to 2.06) usingglobal frailtyandregional frailty,respectively, (adjusted for age, sex, education, smoking status, alcohol consumption and morbidity count). Receiver operating characteristic curves for all-cause mortality were generated for both frailty adaptations.Global frailtyyielded an area under the curve of 0.600 (95% CI: 0.594 to 0.606), compared with 0.5933 (95% CI: 0.587 to 5.99) forregional frailty(p=0.0007).ConclusionsGlobal frailtyleads to higher regional variations in estimated frailty prevalence and stronger associations with mortality, as compared with regional frailty. However, both frailty adaptations in isolation are limited in their ability to discriminate between those who will die during 9 years’ follow-up from those who do not.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Development Of Frailty Classificationsmentioning

confidence: 99%