The importance of calcium in the control of salt intake

Tordoff, Michael G.

doi:10.1016/0149-7634(95)00051-f

Cited by 15 publications

(7 citation statements)

References 96 publications

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“…The adequate intake (AI) for American and Canadian men and women 19-50 years of age is 1000 mg day -1 and the Tolerable Upper Intake Level is 2500 mg day -1 (2). The -1996 Continuing Survey of Food Intakes by Individuals (CSFII) estimated the median intake of calcium in women 18-50 years of age to be around 610 mg day -1 (2). In a more recent National Health and Nutrition Examination Survey (NHANES) (1999)(2000), calcium intake was about 770 mg day -1 for women 20-59 years of age (3).…”

Section: Calcium Intake In the United Statesmentioning

confidence: 99%

Recent developments in calcium‐related obesity research

et al. 2008

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The influence of calcium and dairy food intake on energy balance is the object of a growing scientific literature. This manuscript presents the information discussed by subject experts during a symposium on calcium and obesity, initially planned to document in a comprehensive manner the role of calcium and dairy food on energy balance and body composition. This manuscript is organized into 13 propositions statements which either resume the presentation of an invited speaker or integrate recent developments in calcium-related obesity research. More specifically, the effects of calcium and dairy consumption on body weight and adiposity level, appetite, weight loss intervention outcome, lipid-lipoprotein profile and the risk to develop metabolic syndrome are discussed together with the metabolic mechanisms proposed to explain these effects. Taken together, the observations presented in this manuscript suggest that calcium and dairy food intake can influence many components of energy and fat balance, indicating that inadequate calcium/dairy intake may increase the risk of positive energy balance and of other health problems.

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Section: Calcium Intake In the United Statesmentioning

confidence: 99%

Recent developments in calcium‐related obesity research

et al. 2008

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“…Several studies have examined potential physiological mechanisms underlying calcium deficiency-induced NaCl intake. The renin-angiotensin-aldosterone system (RAAS) is the primary mediator of NaCl intake (67,79,88,92), but indicators of RAAS activity, including blood pressure, urinary sodium excretion, and ECF volume, appear unperturbed in calcium-deficient rats (297,303,305). Moreover, treatment with an aldosterone antagonist or angiotensin II receptor inhibitor had no effect on the NaCl intake of calcium-deprived rats (303).…”

Section: Sodiummentioning

confidence: 99%

“…Thus calcium deficiency is arguably the clearest example of high NaCl intakes where a role for the RAAS has been effectively ruled out (see review in Ref. 297).…”

Section: Sodiummentioning

confidence: 99%

“…Populations with a high demand for calcium have elevated NaCl preferences [e.g., pregnant and lactating women (249), children (16,60,71)]. Moreover, subjects with low calcium intakes prefer significantly higher concentrations of NaCl in tomato juice and other salted foods than do subjects with high calcium intakes (43,297). More generally, a large, well-controlled study found that calcium supplementation reduced cravings of women suffering from premenstrual symptoms (288).…”

Section: Do Humans Have a Calcium Appetite?mentioning

confidence: 99%

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Calcium: Taste, Intake, and Appetite

Tordoff

2001

Physiological Reviews

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157

106

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This review summarizes research on sensory and behavioral aspects of calcium homeostasis. These are fragmented fields, with essentially independent lines of research involving gustatory electrophysiology in amphibians, ethological studies in wild birds, nutritional studies in poultry, and experimental behavioral studies focused primarily on characterizing the specificity of the appetite in rats. Recently, investigators have begun to examine potential physiological mechanisms underlying calcium intake and appetite. These include changes in the taste perception of calcium, signals related to blood calcium concentrations, and actions of the primary hormones of calcium homeostasis: parathyroid hormone, calcitonin, and 1,25-dihydroxyvitamin D. Other influences on calcium intake include reproductive and adrenal hormones and learning. The possibility that a calcium appetite exists in humans is discussed. The broad range of observations documenting the existence of a behavioral limb of calcium homeostasis provides a strong foundation for future genetic and physiological analyses of this behavior.

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“…This too is unfortunate because there is little evidence to suggest that circulating levels of angiotensin or aldosterone are relevant for human sodium consumption [15]. The evidence suggests that the rennin-angiotensin-aldosterone system is crucially involved in the motivation to ingest sodium during sodium deficiency but the human problem is one of avoiding, not finding, sodium [see [82] for discussion].…”

Section: Introductionmentioning

confidence: 99%

Gene discovery and the genetic basis of calcium consumption

Tordoff

2008

Physiology & Behavior

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This review makes the case that gene discovery is a worthwhile approach to the study of ingestive behavior in general and to calcium appetite in particular. A description of the methods used to discover genes is provided for non-geneticists. Areas covered include the characterization of an appropriate phenotype, the choice of suitable mouse strains, the generation of a hybrid cross, interval mapping, congenic strain production, and candidate gene analysis. The approach is illustrated with an example involving mice of the C57BL/6J and PWK/PhJ strains, which differ in avidity for calcium solutions. The variation between the strains can be attributed to at least seven quantitative trait loci (QTLs). One of these QTLs is most likely accounted for by Tas1r3, which is a gene involved in the detection of sweet and umami tastes. The discovery of a novel function for a gene with no previously known role in calcium consumption illustrates the power of gene discovery methods to uncover novel mechanisms.

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The importance of calcium in the control of salt intake

Cited by 15 publications

References 96 publications

Recent developments in calcium‐related obesity research

Recent developments in calcium‐related obesity research

Calcium: Taste, Intake, and Appetite

Gene discovery and the genetic basis of calcium consumption

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