The Importance of Breast Adipose Tissue in Breast Cancer

Kothari, Charu; Diorio, Caroline; Durocher, Francine

doi:10.3390/ijms21165760

Cited by 112 publications

(78 citation statements)

References 274 publications

(340 reference statements)

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“…It produces prolactin and steroid hormones like estrogens thanks to an aromatase. In addition, it participates in epithelial cell growth, angiogenesis, intercellular communication, and milk production [28], and it secretes many growth factors and enzymes involved in beast reshaping during development [29]. Distinct endocrine features can also be exemplified as follow.…”

Section: Breast Adipose Tissue and Pink Adipocytesmentioning

confidence: 99%

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Distinct Shades of Adipocytes Control the Metabolic Roles of Adipose Tissues: From Their Origins to Their Relevance for Medical Applications

et al. 2021

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Adipose tissue resides in specific depots scattered in peripheral or deeper locations all over the body and it enwraps most of the organs. This tissue is always in a dynamic evolution as it must adapt to the metabolic demand and constraints. It exhibits also endocrine functions important to regulate energy homeostasis. This complex organ is composed of depots able to produce opposite functions to monitor energy: the so called white adipose tissue acts to store energy as triglycerides preventing ectopic fat deposition while the brown adipose depots dissipate it. It is composed of many cell types. Different types of adipocytes constitute the mature cells specialized to store or burn energy. Immature adipose progenitors (AP) presenting stem cells properties contribute not only to the maintenance but also to the expansion of this tissue as observed in overweight or obese individuals. They display a high regeneration potential offering a great interest for cell therapy. In this review, we will depict the attributes of the distinct types of adipocytes and their contribution to the function and metabolic features of adipose tissue. We will examine the specific role and properties of distinct depots according to their location. We will consider their cellular heterogeneity to present an updated picture of this sophisticated tissue. We will also introduce new trends pointing out a rational targeting of adipose tissue for medical applications.

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Section: Breast Adipose Tissue and Pink Adipocytesmentioning

confidence: 99%

“…growth factors and enzymes involved in beast reshaping during development [29]. Distinct endocrine features can also be exemplified as follow.…”

Section: Breast Adipose Tissue and Pink Adipocytesmentioning

confidence: 99%

Distinct Shades of Adipocytes Control the Metabolic Roles of Adipose Tissues: From Their Origins to Their Relevance for Medical Applications

et al. 2021

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“…This suggests that the adipose tissue has a crucial role in bone metabolism and its dysregulation can promote metabolic disorders like OP. As reviewed by Kothari et al, adipose tissue is also a crucial player in breast tissue remodeling and carcinogenesis [ 72 ]. The relationship between osteoporosis and breast cancer is puzzling.…”

Section: Overview Of the Most Frequent Osteoimmunological Disordermentioning

confidence: 99%

“…In addition, the transdifferentiation of pink adipocytes, present only during pregnancy and lactation, in white adipose tissue remains essential for proper involution. Interestingly, this process is mediated by Osteopontin ( OPN ), which is highly expressed during lactation and involution while it is not found in other stages of breast development [ 72 , 130 , 131 ]. OPN , also named Secreted Phosphoprotein 1 (SPP1) is also expressed by osteoblasts and is an agonist of bone resorption processes.…”

Section: Osteoimmunology Of the Breast Tissue During A Woman’s Lifmentioning

confidence: 99%

“…By silencing OPN in MDA-MB-231 triple-negative breast cancer cell line (estrogen receptor (ER), progesterone receptor (PR) and receptor tyrosine-protein kinase erbB-2 (HER2) negative), a decrease in the production of hydroxyapatite crystals in an osteogenic medium and a decrease of cell migration were observed [ 135 ]. An excess of involution-related adipogenesis in the breast microenvironment is associated with an excessive production of adipokines [ 72 ]. To fully measure the importance of lobular involution characterization, McDaniel et al isolated mammary glands extracellular matrix from nulliparous rats, and rats undergoing postlactation involution.…”

Section: Osteoimmunology Of the Breast Tissue During A Woman’s Lifmentioning

confidence: 99%

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Breast Cancer and Microcalcifications: An Osteoimmunological Disorder?

Clemenceau

Michou

Diorio

et al. 2020

IJMS

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The presence of microcalcifications in the breast microenvironment, combined with the growing evidences of the possible presence of osteoblast-like or osteoclast-like cells in the breast, suggest the existence of active processes of calcification in the breast tissue during a woman’s life. Furthermore, much evidence that osteoimmunological disorders, such as osteoarthritis, rheumatoid arthritis, or periodontitis influence the risk of developing breast cancer in women exists and vice versa. Antiresorptive drugs benefits on breast cancer incidence and progression have been reported in the past decades. More recently, biological agents targeting pro-inflammatory cytokines used against rheumatoid arthritis also demonstrated benefits against breast cancer cell lines proliferation, viability, and migratory abilities, both in vitro and in vivo in xenografted mice. Hence, it is tempting to hypothesize that breast carcinogenesis should be considered as a potential osteoimmunological disorder. In this review, we compare microenvironments and molecular characteristics in the most frequent osteoimmunological disorders with major events occurring in a woman’s breast during her lifetime. We also highlight what the use of bone anabolic drugs, antiresorptive, and biological agents targeting pro-inflammatory cytokines against breast cancer can teach us.

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Environmental factor reversibly determines cellular identity through opposing Integrators that unify epigenetic and transcriptional pathways

Takahashi,

Ito,

Matsumura

et al. 2023

BioEssays

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Organisms must adapt to environmental stresses to ensure their survival and prosperity. Different types of stresses, including thermal, mechanical, and hypoxic stresses, can alter the cellular state that accompanies changes in gene expression but not the cellular identity determined by a chromatin state that remains stable throughout life. Some tissues, such as adipose tissue, demonstrate remarkable plasticity and adaptability in response to environmental cues, enabling reversible cellular identity changes; however, the mechanisms underlying these changes are not well understood. We hypothesized that positive and/or negative “Integrators” sense environmental cues and coordinate the epigenetic and transcriptional pathways required for changes in cellular identity. Adverse environmental factors such as pollution disrupt the coordinated control contributing to disease development. Further research based on this hypothesis will reveal how organisms adapt to fluctuating environmental conditions, such as temperature, extracellular matrix stiffness, oxygen, cytokines, and hormonal cues by changing their cellular identities.

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The Importance of Breast Adipose Tissue in Breast Cancer

Cited by 112 publications

References 274 publications

Distinct Shades of Adipocytes Control the Metabolic Roles of Adipose Tissues: From Their Origins to Their Relevance for Medical Applications

Distinct Shades of Adipocytes Control the Metabolic Roles of Adipose Tissues: From Their Origins to Their Relevance for Medical Applications

Breast Cancer and Microcalcifications: An Osteoimmunological Disorder?

Environmental factor reversibly determines cellular identity through opposing Integrators that unify epigenetic and transcriptional pathways

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