The Importance of Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) and Raman Biospectroscopy of Single-Walled Carbon Nanotubes (SWCNT) and Multi- Walled Carbon Nanotubes (MWCNT) in Interpreting Infrared and Raman Spectra of Human Cancer Cells, Tissues and Tumors

Heidari, Alireza; Esposito, Jennifer; Caissutti, Angela

doi:10.35702/onc.10007

Cited by 7 publications

(4 citation statements)

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“…The unpaired electrons of free-radical accumulation cause oxidative stress in the body. Oxidative stress causes cell damage leading to various health issues such as chronic disease, cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular diseases, neurodegenerative diseases, respiratory disorders [210][211][212][213][214][215][216][217][218] and also the induced oxidative stress causes bronchial contraction by the release of cyclooxygenase and lipoxygenase in the airway that leads to bronchial asthma in human [219][220][221][222][223][224][225]. Asthma is a chronic inflammatory lung disease that happens due to the respiratory infection triggered by the inhalation of allergens like tobacco smoke, air pollutants, genetic and environment factors [226][227][228][229][230][231][232] which leads to the release of histamine and leukotrienes from the mast cell in the lung.…”

Section: Introductionmentioning

confidence: 99%

Okadaic Acid Time-Resolved Absorption and Resonance FT-IR and Raman Biospectroscopy and Density Functional Theory (DFT) Investigation of Vibronic-Mode Coupling Structure in Vibrational Spectra Analysis

Heidari¹,

Esposito²,

Caissutti³

2019

Int J Analyt Bioanalyt Methods

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Okadaic acid, C 44 H 68 O 13, is a toxin produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. One of the primary causes of diarrhetic shellfish poisoning, Okadaic acid is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells. A polyketide, polyether derivative of a C38 fatty acid, Okadaic acid and other members of its family have shined light upon many biological processes both with respect to dinoflagellate polyketide synthesis as well as the role of protein phosphatases in cell growth. Parameters such as FT -IR and Raman vibrational wavelengths and intensities for single crystal Okadaic Acid are calculated using density functional theory and were compared with empirical results. The investigation about vibrational spectrum of cycle dimers in crystal with carboxyl groups from each molecule of acid was shown that it leads to create Hydrogen bonds for adjacent molecules. The current study aimed to investigate the possibility of simulating the empirical values. Analysis of vibrational spectrum of Okadaic Acid is performed based on theoretical simulation and FT-IR empirical spectrum and Raman empirical spectrum using density functional theory in levels of HF/6-31G * , HF/6-31++G ** , MP2/6-31G, MP2/6-31++G ** , BLYP/6-31G, BLYP/6-31++G ** , B3LYP/6-31G and B3LYP6-31-HEG ** . Vibration modes of methylene, carboxyl acid and phenyl cycle are separately investigated. The obtained values confirm high accuracy and validity of results obtained from calculations .

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Section: Introductionmentioning

confidence: 99%

Okadaic Acid Time-Resolved Absorption and Resonance FT-IR and Raman Biospectroscopy and Density Functional Theory (DFT) Investigation of Vibronic-Mode Coupling Structure in Vibrational Spectra Analysis

Heidari¹,

Esposito²,

Caissutti³

2019

Int J Analyt Bioanalyt Methods

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“…According to the statistical results, we can see the high frequency of gastric cancer in, Japan, China, Central and South America, Eastern Europe and parts of the middle east. Higher rates usually have been seen group with lower socioeconomic [225][226][227][228][229][230][231][232][233][234][235][236][237][238][239][240][241]. Some signs of this cancer are indigestion or heartburn, vomiting, diarrhea, constipation and having blood in stool.…”

Section: Population Differences In Cancer Prevalencementioning

confidence: 99%

Hereditary immunity in cancer

Heidari

Schmitt

Henderson

et al. 2020

IJAC

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Cancer is one of the malignant diseases and millions of people worldwide die from cancer annually. Breast cancer diagnosis requires the analysis of images and attributes as well as collecting many clinical and mammography variables. In diagnosis of breast cancer, it is im-portant to determine whether a tumor is benign or malignant. The information about breast cancer risk prediction along with the type of tu-mor are crucial for patients and effective medical decision making. An ideal diagnostic system could effectively distinguish between benign and malignant cells; however, such a system has not been created yet. In this study, a model is developed to improve the prediction probabil-ity of breast cancer. It is necessary to have such a prediction model as the survival probability of breast cancer is high when patients are diagnosed at early stages.

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“…Free radicals are atoms with unpaired electrons which can cause various diseases. cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular diseases, neurodegenerative diseases, respiratory disorders [211][212][213][214][215][216][217][218][219] and also the induced oxidative stress causes bronchial contraction by the release of cyclooxygenase and lipooxygenase in the airway that leads to bronchial asthma in human [220][221][222][223][224][225][226]. Asthma is a chronic inflammatory lung disease that happens due to the respiratory infection triggered by the inhalation of allergens like tobacco smoke, air pollutants, genetic and environment factors [227][228][229][230][231][232][233] which leads to the release of histamine and leukotrienes from the mast cell in the lung.…”

Section: Introductionmentioning

confidence: 99%

Tetrodotoxin (TTX) Time–Resolved Absorption and Resonance FT–IR and Raman Biospectroscopy and Density Functional Theory (DFT) Investigation of Vibronic–Mode Coupling Structure in Vibrational Spectra Analysis

Heidari

Esposito

Caissutti

2019

JNDC

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Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish; several of these species carry the toxin. Although tetrodotoxin was discovered in these fish and found in several other aquatic animals (e.g., in blue-ringed octopuses, rough-skinned newts, and moon snails), it is actually produced by certain infecting or symbiotic bacteria like Pseudoalteromonas, Pseudomonas, and Vibrio as well as other species found in animals.Parameters such as FT-IR and Raman vibrational wavelengths and intensities for single crystal Tetrodotoxin (TTX) are calculated using density functional theory and were compared with empirical results. The investigation about vibrational spectrum of cycle dimers in crystal with carboxyl groups from each molecule of acid was shown that it leads to create Hydrogen bounds for adjacent molecules. The current study aimed to investigate the possibility of simulating the empirical values. Analysis of vibrational spectrum of Tetrodotoxin (TTX) is performed based on theoretical simulation and FT-IR empirical spectrum and Raman empirical spectrum using density functional theory in levels of F/6-31G

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The Importance of Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) and Raman Biospectroscopy of Single-Walled Carbon Nanotubes (SWCNT) and Multi- Walled Carbon Nanotubes (MWCNT) in Interpreting Infrared and Raman Spectra of Human Cancer Cells, Tissues and Tumors

Cited by 7 publications

References 0 publications

Okadaic Acid Time-Resolved Absorption and Resonance FT-IR and Raman Biospectroscopy and Density Functional Theory (DFT) Investigation of Vibronic-Mode Coupling Structure in Vibrational Spectra Analysis

Okadaic Acid Time-Resolved Absorption and Resonance FT-IR and Raman Biospectroscopy and Density Functional Theory (DFT) Investigation of Vibronic-Mode Coupling Structure in Vibrational Spectra Analysis

Hereditary immunity in cancer

Tetrodotoxin (TTX) Time–Resolved Absorption and Resonance FT–IR and Raman Biospectroscopy and Density Functional Theory (DFT) Investigation of Vibronic–Mode Coupling Structure in Vibrational Spectra Analysis

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