The Importance of Antimicrobial Resistance Monitoring Worldwide and the Origins of SENTRY Antimicrobial Surveillance Program

Abstract

The origins of how and why the SENTRY Antimicrobial Surveillance Program was created are briefly described, with additional details on how the isolates are collected and tested as well as the important uses of the data in monitoring antimicrobial resistance and drug development.

Difficult-to-Treat Antibiotic-Resistant Gram-Negative Pathogens in the Intensive Care Unit: Epidemiology, Outcomes, and Treatment

“…Monitoring trends in antibiotics resistance is critical to understand the scope of the problem, allowing for the evaluation of interventions aimed at slowing the progression of resistance and controlling outbreaks, yet remains challenging due to the variety of ways in which epidemiological data are collected and reported. 15,16 It is currently estimated that there are 23,000 deaths per year attributable to antibiotic resistance in the United States and 33,000 deaths per year in the European Union (EU) and European Economic Area (EAA). 17 However, the accuracy of these estimates has been challenged by the scientific community.…”

“…2 (3 points), source of BSI (bloodstream infection) other than urinary or biliary tract (3 points), and inappropriate early targeted therapy (2 points). Low scores (0-8) are associated with mortality rates of 18% while high scores (14)(15)(16)(17) are associated with a mortality of 80%. In patients with septic shock caused to KPC-producing K. pneumoniae treatment with a colistin-containing antibiotic regimen, use of two or more in vitro active antibiotics as definitive therapy and control of a removable source of infection were associated with improved outcomes while colistin resistance and intra-abdominal source were associated with death.…”

Global Trends of Antimicrobial Susceptibility of Ceftaroline and Ceftazidime-Avibactam: A Surveillance Study from the ATLAS Program (2012-2016)

“…35 There is a plea for worldwide, automated, and comprehensive surveillance of antimicrobial resistance patterns. 8,36,37 Such surveillance can help optimize the worldwide use of antibiotics to improve infection control and minimize the apparition of resistant strains. 38 In fact, surveillance and proper actions are necessary to avoid medical, social, and economic setbacks that could threatens the very fabric of the global community.…”

“…5 Consequently, the availability of updated epidemiological data on antibiotic resistance is needed to adapt the treatment strategies to the actual reality, which changes at an alarming rate. 4,[6][7][8] Ceftaroline is a fth-generation broad-spectrum cephalosporin.It isactive mainly against MRSA and Gram-positive bacteria,but also shows some e cacy against Gram-negative bacteria. 9 Ceftarolineis indicated for community-acquired pneumonia and complicated skin infections.…”

Global trends of antimicrobial susceptibility of ceftaroline and ceftazidime-avibactam: a surveillance study from the ATLAS program (2012-2016)

“…5 Consequently, updated epidemiological data on antibiotic resistance is needed to adapt the treatment strategies to the reality, which changes at an alarming rate. 4,[6][7][8] Ceftaroline is a fth-generation broad-spectrum cephalosporin.It ismainly active against methicillin-resistant Staphylococcus aureus and Gram-positive bacteria,but also against Gram-negative bacteria. 9 Ceftarolineis indicated for community-acquired pneumonia and complicated skin infections.…”