Knowledge management (KM) is about enhancing the use of organizational knowledge through sound practices of information management and organizational learning. The study emphasizes on information technology, organizational learning, and knowledge management in higher education institutes of Pakistan. The impact of knowledge management components and practices are empirically tested through econometric techniques. The study uses a sample of 26 universities of Khyber Pakhtoonkhawa (KPK) province of Pakistan, both in the public and private sectors.The results indicate that knowledge management practices measured through information technology, organization, and knowledge significantly affect organizational performance of the universities.