The Implications of Genetic Susceptibility for the Prevention of Colorectal Cancer: A Qualitative Study of Older Adults’ Understanding

Lucke, Jayne; Hall, Wayne; Ryan, Bree; Owen, Neville

doi:10.1159/000121399

Cited by 9 publications

(11 citation statements)

References 41 publications

(38 reference statements)

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“…As Lucke et al (13), and Walter et al (14), have found, personal experience with a particular condition further shapes these understandings. Thus, if the person one knows with diabetes has a family history of it, one is more likely to assume that diabetes ‘is hereditary’ than if the person whom one knows with diabetes does not have such a family history.…”

Section: Conceptions Of Hereditary Patterns Are Shaped By Social Expementioning

confidence: 91%

Public understandings of genetics and health

Condit

2009

Clinical Genetics

102

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This review of adult public understandings of genetics related to health indicates that the public's understandings overlap with those of professionals in some areas, but not others. Specifically, the majority of the world's people who have been studied understand genetics through the lens of heredity, not in terms of the structural and functional nature of genes. Public understandings of hereditary processes are influenced by models of social relationships and by experiential familiarity with particular conditions as much as by academic research results. Most people hold a fairly strong belief that many health conditions are substantially influenced by both genes and other factors. However, they do not have a stable understanding of the nature of gene-environment interactions. People in cultures where science is not a prominent cultural mode are even less likely to hold the belief structures of professional geneticists. In some areas--notably with regard to racialization of genetic medicine and characterizations of genetic variations as 'mutations'--at least some members of the public strongly reject some geneticists' constructions. Public understanding of details pertinent to genetic testing generally appears to be weak.

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Section: Conceptions Of Hereditary Patterns Are Shaped By Social Expementioning

confidence: 91%

Public understandings of genetics and health

Condit

2009

Clinical Genetics

102

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“…42,43 Research on lay understanding of health has shown that most Western populations realize that health is a product of variable inputs of both personal behavior and familial inheritance. 36,44–51 Evidence supports the public’s nuanced understanding of the role of genetics in health that varies based on the character of the disease, 46,49 the family’s experience with the disease, 52,53 the character of the treatments available, the pathways by which the genes act, 54 and the communication approach used to present genetic risk and behavioral options. 37 Research to identify these human factors more precisely is essential if genomic discoveries and their applications are to be most useful and least harmful.…”

Section: Priority Areas In Communication Behavioral and Social Sciementioning

confidence: 98%

Future Health Applications of Genomics

McBride

Bowen

Brody

et al. 2010

American Journal of Preventive Medicine

133

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Despite the quickening momentum of genomic discovery, the communication, behavioral, and social sciences research needed for translating this discovery into public health applications has lagged behind. The National Human Genome Research Institute held a 2-day workshop in October 2008 convening an interdisciplinary group of scientists to recommend forward-looking priorities for translational research. This research agenda would be designed to redress the top three risk factors (tobacco use, poor diet, and physical inactivity) that contribute to the four major chronic diseases (heart disease, type 2 diabetes, lung disease, and many cancers) and account for half of all deaths worldwide. Three priority research areas were identified: (1) improving the public’s genetic literacy in order to enhance consumer skills; (2) gauging whether genomic information improves risk communication and adoption of healthier behaviors more than current approaches; and (3) exploring whether genomic discovery in concert with emerging technologies can elucidate new behavioral intervention targets. Important crosscutting themes also were identified, including the need to: (1) anticipate directions of genomic discovery; (2) take an agnostic scientific perspective in framing research questions asking whether genomic discovery adds value to other health promotion efforts; and (3) consider multiple levels of influence and systems that contribute to important public health problems. The priorities and themes offer a framework for a variety of stakeholders, including those who develop priorities for research funding, interdisciplinary teams engaged in genomics research, and policymakers grappling with how to use the products born of genomics research to address public health challenges.

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“…Genetic testing for cancer susceptibility has transformed the nature of communication between clinicians and their patients about disease risk, screening, treatment, and prevention strategies. Effective communication with patients about disease risk is important because previous research has demonstrated that one’s risk perception has the potential to positively influence screening behaviors and treatment decisions (Lipkus et al 2000; Lucke et al 2008), both of which may improve health outcomes. Yet, the extent to which lay theories of disease influence the interpretation of genetic information about cancer risk among patients and their families remains largely unanswered.…”

Section: Introductionmentioning

confidence: 99%

“The Cancer Bond”: Exploring the Formation of Cancer Risk Perception in Families with Lynch Syndrome

Palmquist

Koehly

Peterson

et al. 2010

Journal of Genetic Counseling

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This study explores the social context of hereditary cancer risk perception in three families, an African-American family, a Mexican-American family, and a Caucasian family, each with Lynch Syndrome documented by a mismatch repair gene mutation. Communication network assessments measured family communication about cancer experiences and genetic testing information among a total of 26 participants. Participant narratives were evaluated to gain insight into how family cancer experiences and genetic testing information have shaped perceptions of cancer risk. Analysis of communication networks indicated that some families discussed cancer experiences to a greater extent than genetic testing information, and vice-versa. Interviews elucidated that sharing both types of health information led participants to conceptualize linkages among a strong family history of cancer, genetic testing information, and cancer prevention strategies. Understanding how different types of family communication influence the formation of perceived hereditary disease risk may enhance efforts to tailor genetic counseling services for families.

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The Implications of Genetic Susceptibility for the Prevention of Colorectal Cancer: A Qualitative Study of Older Adults’ Understanding

Cited by 9 publications

References 41 publications

Public understandings of genetics and health

Public understandings of genetics and health

Future Health Applications of Genomics

“The Cancer Bond”: Exploring the Formation of Cancer Risk Perception in Families with Lynch Syndrome

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