The Implication of a Novel Herbal Formulation in Reversal of Drug-Resistance for Cancer Treatment

Ankita, Umrao; A, Rao Gururaj; S.G.A, Rao Rao; Dasgupta, Debjani; A, Rao Jyothsna

doi:10.5530/ctbp.2020.4.44

Cited by 1 publication

(3 citation statements)

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“…SR033, an herbal formula composed of green tea, cinnamon, turmeric, cardamom, and cloves, has reported anti-oxidative, chemoprotective, anti-proliferative, and anti-inflammatory effects. 38 Co-administration of SR033 and 5-FU has been shown to increase the apoptosis rate in cervical cancer cells.…”

Section: Resultsmentioning

confidence: 99%

“… 23 , 26 Additionally, SR033 showed anticancer efficacy in 5-FU-resistant HeLa-R cells. 38 Overcoming anticancer drug resistance could potentially offer renewed therapeutic options for patients who no longer respond to chemotherapy alone. Another key finding is that some of these herbal formulas help mitigate the toxicity associated with chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, SR033 has been reported to reduce oxidative stress, a known adverse effect of chemotherapy. 38 Furthermore, SH003 has been found to alleviate neuropathic pain induced by paclitaxel and docetaxel. 57 , 58 If such co-administration of herbal medicines and chemotherapy has similar effects in humans, patients who would otherwise need to discontinue treatment or reduce dosage due to adverse effects might be able to continue treatment.…”

Section: Discussionmentioning

confidence: 99%

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Synergistic and Additive Effects of Herbal Medicines in Combination with Chemotherapeutics: A Scoping Review

Jung,

Cheon

2024

Integr Cancer Ther

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Background: Natural products are increasingly gaining interest as potential new drug candidates for cancer treatment. Herbal formula, which are combinations of several herbs, are primarily used in East Asia and have a long history of use that continues today. Recently, research exploring the combination of herbal formulas and chemotherapy for cancer treatment has been on the rise. Methods: This study reviewed research on the co-administration of herbal formulas and chemotherapy for cancer treatment. The databases PubMed, Embase, and Cochrane Library were used for article searches. The following keywords were employed: “Antineoplastic agents,” “Chemotherapy,” “Phytotherapy,” “Herbal medicine,” “Drug synergism,” and “Synergistic effect.” The selection process focused on studies that investigated the synergistic interaction between herbal formulas and chemotherapeutic agents. Results: Among the 30 studies included, 25 herbal formulas and 7 chemotherapies were used. The chemotherapy agents co-administered included cisplatin, 5-fluorouracil, docetaxel, doxorubicin, oxaliplatin, irinotecan, and gemcitabine. The types of cancer most frequently studied were lung, breast, and colon cancers. Most studies evaluating the anticancer efficacy of combined herbal formula and chemotherapy treatment were conducted in vitro or in vivo. Discussion: Most studies reported synergistic effects on cytotoxicity, apoptosis, and tumor growth inhibition. These effects were found to be associated with cell cycle arrest, anti-angiogenesis, and gene expression regulation. Further studies leading to clinical trials are required. Clinical experiences in East Asian countries could provide insights for future research.

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Section: Resultsmentioning

confidence: 99%