2019
DOI: 10.1002/jlb.4ab1118-416rr View full text |Buy / Rent full text
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Abstract: Trypanossoma cruzi (T. cruzi), the causative protozoan of Chagas disease (CD) invades many cell types, including central nervous system (CNS) cells triggering local lesions and neurological impact. Previous work from our group described NLRP3 inflammasomes as central effectors for the parasite control by macrophages. Recent evidences demonstrate that NLRP3 can be activated in CNS cells with controversial consequences to the control of infections and inflammatory pathologies. However, the relative contribution … Show more

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“…As well, microglial cells are also susceptible to be infected by this parasite, thus generating another cellular scenario for cohabitation. However, astrocytes appear to be more permissive to parasite replication because the activation of the NLRP3 inflammasomes is lower than in microglia-infected cells (Pacheco et al, 2019).…”
Section: Discussionmentioning
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“…As well, microglial cells are also susceptible to be infected by this parasite, thus generating another cellular scenario for cohabitation. However, astrocytes appear to be more permissive to parasite replication because the activation of the NLRP3 inflammasomes is lower than in microglia-infected cells (Pacheco et al, 2019).…”
Section: Discussionmentioning
“…For example, NLRP3 deficiency in mice is associated with hippocampal dysfunction as well as anxiety-like behavior ( Komleva et al, 2021 ). Absence of NLRP3 renders astrocytes highly permissive to Trypanosoma cruzi replication in the context of Chagas disease ( Pacheco et al, 2019 ). Mice treated with LPS in their hippocampus responded by enhancing the astrocytic production of neopterin, a biomarker for immune system activation; neopterin inhibited inflammasome activation in pre-conditioned human astrocytes ( de Paula Martins et al, 2018 ).…”
Section: Inflammasomes and Astrocytesmentioning
“…As described above, the ongoing neuroinflammation is reinforced by key innate immune sensor(s) for danger signals referred to as inflammasomes. In addition to microglia, astrocytes also express various members of the inflammasome family, as reported in various disease models [ 78 , 80 , 129 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 ]. NLRP1 is the first reported inflammasome expressed in the rat primary cortical astrocytes that is activated by purinergic receptors [ 174 ].…”
Section: Role Of Astrocytes—inflammasomes and Agingmentioning