The impacts of individual and combined exposure to cadmium and lead on intraocular pressure, electroretinography, and residual changes in the rabbit eyes

Abd‐Elhakim, Yasmina M.; Bohi, Khlood M. El; Sharkawy, Nabela I. El; Ghali, Manar A; Haseeb, Sarah

doi:10.1007/s11356-019-06446-7

Cited by 4 publications

(2 citation statements)

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“…Oxidative stress is considered the primary contributory agent in the pathogenesis of PbAc poisoning [ 25 ]. It is classified as a multi-organ toxin as it interferes with many organ functions, including neurological, behavioral, immunological, renal, hepatic, reproductive, ocular, and hematological [ 26 , 27 , 28 , 29 ]. PbAc exposure has been associated with decreased sperm concentration, count, and motility and decreased spermatozoa activity [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats

et al. 2022

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This study examined the effects of exposure to lead acetate (PbAc) and/or aluminum trioxide nanoparticles (Al2O3NPs) on testicular function. Additionally, the probable reproprotective effects of quercetin (QTN) against Al2O3NPs and PbAc co-exposure in male Sprague Dawely rats were assessed. Al2O3NPs (100 mg/kg b.wt.), PbAc (50 mg/kg b.wt.), and QTN (20 mg/kg b.wt.) were orally administered for 60 days. Then, spermiogram, histopathological examinations of the testis and accessory glands, and immunohistochemical detection of androgen receptors (AR) and tumor necrotic factor alpha (TNF-α) were achieved. Moreover, serum levels of male sex hormones and testicular levels of antioxidant indices were estimated. The results showed that Al2O3NPs and/or PbAc caused significant sperm abnormalities, testicular oxidative stress, and histopathological changes. Furthermore, serum testosterone, LH, and FSH levels significantly decreased, while estradiol levels significantly increased. The Al2O3NPs and/or PbAc co-exposed group had more obvious disturbances. Furthermore, QTN co-administration significantly reversed the Al2O3NPs and PbAc-induced testicular histopathological alterations, reduced antioxidant defenses, and altered AR and TNF-α immune expression in testicular tissues. Conclusively, Al2O3NPs and/or PbAc evoked testicular dysfunction by inducing oxidative injury and inflammation. However, QTN oral dosing effectively mitigated the negative effects of Al2O3NPs and PbAc by suppressing oxidative stress and inflammation and improving the antioxidant defense system.

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Section: Introductionmentioning

confidence: 99%

Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats

et al. 2022

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“…Cadmium (Cd) is a common environmental and occupational metallic toxicant that harms humans' health [ 10 , 11 ]. Cd poisoning induces nephrotoxicity, osteoporosis, cardiovascular problems, testicular necrosis, renal failure, ocular toxicity, and neurological problems [ 12 , 13 ]. Additionally, Cd exposure causes severe edema, Leydig cell damage, decreased testosterone in the blood and testes, fewer germ cell junctions in the seminiferous tubules, a lack of integral membrane proteins at the Sertoli cell interface of the BTB, and a decrease in sperm motility and count [ 14 ].…”

Section: Introductionmentioning

confidence: 99%