The impacts of increased nitrate supply on<i>Catharanthus roseus</i>growth and alkaloid accumulations under ultraviolet-B stress

Guo, Xiao‐Na; Chang, Bowen; Zu, Yuangang; Tang, Zhonghua

doi:10.1080/17429145.2014.886728

Cited by 24 publications

(12 citation statements)

References 32 publications

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“…The bis-indole alkaloids are found only in Catharanthus roseus leaves. Leaf tissue concentration of total and of dimeric alkaloids is highly dependent on the C. roseus cultivar [36] and can be triggered by UV-light and nitrogen source [37,38]. But still, the accumulation of vinblastine and vincristine remain low, vinblastine 0.1-20 mg/g leaf dry mass and vincristine 0.1-1.2 mg/g leaf dry mass [37,38].…”

Section: Monoterpenoid Alkaloid (Mia) Biotechnologymentioning

confidence: 97%

“…But still, the accumulation of vinblastine and vincristine remain low, vinblastine 0.1-20 mg/g leaf dry mass and vincristine 0.1-1.2 mg/g leaf dry mass [37,38]. Although the monomeric building blocks of vinblastine and vincristine, that is, vindoline and catharanthine (Figure 3), are major alkaloids in C. roseus leaves (0.1-2 mg/g leaf dry mass) [37,38], the desired dimers accumulate to very low concentrations in planta, and plants still are the source for extraction of vinblastine and vincristine. Many efforts have been made to employ C. roseus cell and tissue cultures for alkaloid production, however, without results that would appear commercially attractive [39].…”

Section: Monoterpenoid Alkaloid (Mia) Biotechnologymentioning

confidence: 99%

“…Leaf tissue concentration of total and of dimeric alkaloids is highly dependent on the C. roseus cultivar [36] and can be triggered by UV-light and nitrogen source [37,38]. But still, the accumulation of vinblastine and vincristine remain low, vinblastine 0.1-20 mg/g leaf dry mass and vincristine 0.1-1.2 mg/g leaf dry mass [37,38]. Although the monomeric building blocks of vinblastine and vincristine, that is, vindoline and catharanthine (Figure 3), are major alkaloids in C. roseus leaves (0.1-2 mg/g leaf dry mass) [37,38], the desired dimers accumulate to very low concentrations in planta, and plants still are the source for extraction of vinblastine and vincristine.…”

Section: Monoterpenoid Alkaloid (Mia) Biotechnologymentioning

confidence: 99%

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Exploiting plant alkaloids

Schläger

Dräger

2016

Current Opinion in Biotechnology

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Section: Monoterpenoid Alkaloid (Mia) Biotechnologymentioning

confidence: 97%

Section: Monoterpenoid Alkaloid (Mia) Biotechnologymentioning

confidence: 99%

Section: Monoterpenoid Alkaloid (Mia) Biotechnologymentioning

confidence: 99%

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Exploiting plant alkaloids

Schläger

Dräger

2016

Current Opinion in Biotechnology

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“…Laurus nobilis L.(Bernal et al, 2015) and Prunella vulgaris L (Zhang et al, 2017). whereas, in Catharanthus roseus L (Guo et al, 2014),. Glycine max L. and Zea mays L. (shen et al, 2015) plant biomass decreased by UV-B radiation.…”

mentioning

confidence: 99%

Physiological and Biochemical Changes Induced by UV-B Radiation in Rosemary Plants Grown Under Salinity Stress

Moghaddam¹,

Arouiee²,

Moshtaghi³

et al. 2019

J. Ecol. Eng.

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Plants are exposed to solar ultraviolet radiation due to use of sunlight for photosynthesis. Additionally, salinity in soil or water influences the plant productivity and quality considerably. Moreover, when plants are simultaneously exposed to multiple stresses, one form of stress can affect the response to other stress. Particularly, it has been shown that they can benefit from dual tolerance as salinity and UV-B radiation are applied together. In order to understand the effects of UV-B radiation and salinity stress on some physiological and biochemical parameters, one-year-old cuttings of rosemary plants were grown under different levels of ultraviolet B radiation (0, 4.32 and 6.05 kJ m-2 d-1) and salinity stress (control, 50, 100 and 150 mM NaCl). The results showed that 4.32 kJ m-2 d-1 UV-B treatment significantly increased plant biomass up to 17.9% as compared to control. However, by increasing salinity to 150 mM, plant biomass significantly decreased up to 18.1%, as compared to control. Regardless of UV-B treatments, plants, grown under 100 mM salinity stress, had produced 2.8 times higher total phenolic compounds (TPC) and also have greater antioxidant activity (33.1%) in comparison to control. Both treatments, enhanced UV-B radiation and salinity stress, significantly increased the concentration of proline, hydrogen peroxide (H 2 O 2) and malondealdehyde (MDA). In relation of total soluble sugar (TSS) and ion content, both treatments acted in an opposing manner. In turn, the enhanced UV-B radiation decreased concentration of TSS and the Na + content in leaves, salinity stress increased the concentration of TSS, as well as the Na + content in leaves and root. The plants grown under 150 mM salinity level accumulated 5.32 and 2.83 times higher Na + ions in leaves and roots, respectively, than control. In addition, salinity significantly decreased the relative water content (RWC), photosynthetic pigments and K + content in leaves and roots. The interaction between UV-B irradiation and salinity showed that the UV-B radiation improved the K + content in leaves, RWC and membrane stability and consequently resulted in a better tolerance of rosemary to salinity.

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“…For the stable supply of these drugs in Japan, it is desirable to produce DIAs domestically. In addition, the regulation system of alkaloid content in C. roseus is influenced by environmental conditions, such as light intensity (Liu et al, 2011;Fukuyama et al, 2015) and nitrogen content in fertilizer (Gholamhoss et al, 2011;Guo et al, 2014). Since it is necessary to control environmental conditions of C. roseus cultivation strictly for stable DIAs production, this cultivation would be preferred to operate in an enclosed environmentally controlled room with artificial lighting, such as a plant factory.…”

Section: Introductionmentioning

confidence: 99%

Effects of Ultraviolet A Supplemented with Red Light Irradiation on Vinblastine Production in <i>Catharanthus roseus</i>

Fukuyama

Ohashi-Kaneko

Hirata

et al. 2017

Environmental Control in Biology

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We investigated whether it is possible to produce vinblastine by irradiation of blue light (B, 440 nm) and ultraviolet A light (UVA, 370 nm) to Catharanthus roseus for domestic production of vinblastine using an environmentally controlled room with artificial lighting, such as a plant factory. Catharanthus roseus plants were cultivated under red light (R, 660 nm) for 28 d and then were cultivated under 3 light quality treatments: UVA supplemented with R, B, or R for 7 d. At 3 d after treatments, vinblastine content in the leaves increased sharply under UVA supplemented with R compared with R alone. The vinblastine content under B was 1/6 of that under UVA supplemented with R. Vinblastine content increased as the UVA intensity was increased from 0 to 10 Wm 2 . UVA irradiation to the leaf discs made from the younger leaves raised the vinblastine content in the leaf discs more than those from the aged leaves. Therefore, UVA light should be irradiated to the young plants at early vegetable stage. For the domestic production of vinblastine, we proposed that the cultivation method of irradiating young plants with 10 Wm 2 UVA for more than 3 d.

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The impacts of increased nitrate supply onCatharanthus roseusgrowth and alkaloid accumulations under ultraviolet-B stress

Cited by 24 publications

References 32 publications

Exploiting plant alkaloids

Exploiting plant alkaloids

Physiological and Biochemical Changes Induced by UV-B Radiation in Rosemary Plants Grown Under Salinity Stress

Effects of Ultraviolet A Supplemented with Red Light Irradiation on Vinblastine Production in <i>Catharanthus roseus</i>

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