The Impacts of ACE Activity according to ACE I/D Polymorphisms on Muscular Functions of People Aged 65

Kang, Hanqing; Kim, Chul-Hyun; Park, Dong-Sik; Choi, Seonghoon; Lee, Donghoon; Nam, Hee-Seung; Hur, Jin-Gang; Woo, Ji-Hea

doi:10.5535/arm.2012.36.4.433

Cited by 9 publications

(7 citation statements)

References 35 publications

(39 reference statements)

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“…ACE activity and ACE polymorphism were generally not connected with muscle strength. 34 – 37 Kang et al 34 showed no interrelation between the handgrip strength and the ACE activity (but showed it for muscle fatigability) among older Koreans. Similarly, Bustamante-Ara et al 35 reported no association between ACE genotype and handgrip strength as well as leg press strength and functional performance measured with walking speed and step test in nonagenarians.…”

Section: Discussionmentioning

confidence: 99%

Relationship of quadriceps muscle power and optimal shortening velocity with angiotensin-converting enzyme activity in older women

Kostka¹,

Sikora

Kostka³

2017

CIA

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BackgroundThe goal of this study was to assess whether angiotensin-converting enzyme (ACE) activity is related to muscle function (strength, power and velocity), as well as to assess if ACE inhibitors (ACEIs) and other angiotensin system blocking medications (ASBMs) influence muscle performance in elderly women.Subjects and methodsNinety-five community-dwelling elderly women took part in this study. Anthropometric data, blood ACE activity analysis, maximum power (Pmax) and optimal shortening velocity (υopt) of the knee extensor muscles, handgrip strength, physical activity (PA) and functional performance were measured.ResultsWomen taking ACEI were on average almost 2 years older than the women who did not take ACEI. They took more medicines and were also characterized by significantly lower level of ACE, but they did not differ in terms of PA level, results of functional performance and parameters characterizing muscle functions. No correlations of ACE activity with Pmax and handgrip strength, as well as with PA or functional performance were found. Higher ACE activity was connected with lower υopt for women who did not take any ASBMs (rho =−0.37; p=0.01).ConclusionSerum ACE activity was not associated with muscle strength, power and functional performance in both ASBM users and nonusers, but was associated with optimal shortening velocity of quadriceps muscles in older women. Further prospective studies are needed to assess if ACEIs or other ASBMs may slow down the decline in muscle function and performance.

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Section: Discussionmentioning

confidence: 99%

Relationship of quadriceps muscle power and optimal shortening velocity with angiotensin-converting enzyme activity in older women

Kostka¹,

Sikora

Kostka³

2017

CIA

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“…In contrast, among older people deletion polymorphism of ACE gene (DD), connected with higher level of angiotensin II, was associated with low muscle mass 33 . Similarly, advanced cancer patients with DD ACE gene polymorphism were characterized by higher serum ACE activity but lower hand grip strength compared with ACE insertion group 34,35 .…”

Section: Discussionmentioning

confidence: 90%

Quadriceps muscle power and optimal shortening velocity are inversely related to angiotensin converting enzyme activity in older men

et al. 2021

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Background: Methods which potentially could prevent age-related loss of muscle mass and function are still being sought. There are various attempts to use pharmacological agents to prevent loss of muscle mass, but the effectiveness of many of them still needs to be confirmed. One of the promising therapeutics are Angiotensin Converting Enzyme Inhibitors (ACEIs) and lowering of serum ACE activity. The goal of this study was to assess if taking Angiotensin Converting Enzyme Inhibitors (ACEI) and other angiotensin system blocking medications (ASBMs) can modify muscle performance in older men as well as to assess the association of serum ACE activity with muscle strength, power, muscle contraction velocity and functional performance. Methods: Seventy-nine older men took part in the study. Muscle function was assessed with hand grip strength, maximum power relative to body mass (Pmax) and optimal shortening velocity (Ʋopt) of the knee extensor muscles. Anthropometric data, ACE activity and functional performance were also measured. Results: Negative correlations between ACE activity and Pmax (rho=-0.29, p=0.04) as well as Ʋopt (rho=-0.31, p=0.03) in a group of patients not taking ACEI and between ACE activity and Ʋopt (rho=-0.22, p=0.05) in the whole group of men were found. Positive relationship between age and ACE activity was demonstrated (rho=0.26, p=0.02). Age was the only selected variable in the multiple regression analyses to determine both Pmax and Ʋopt. Conclusions: Taking ACEI is not associated with a functional performance in older men of the same age and with the same anthropometric parameters. Serum ACE activity negatively associates to muscle power and muscle contraction velocity.

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“…Previous studies suggest that individuals with a higher frequency of the ACE DD genotype have greater strength/power than those with genotype II and ID overexpression [ 32 ]. A recent meta-analysis study found that the predominance of ACE genotype II is indicated as advantageous for the performance of individuals aiming for endurance performance [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Association between ACTN3 (R577X), ACE (I/D), BDKRB2 (-9/+9), and AGT (M268T) polymorphisms and performance phenotypes in Brazilian swimmers

de Albuquerque-Neto,

Santos,

Silvino

et al. 2024

BMC Sports Sci Med Rehabil

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Background The influence of genetic polymorphisms on athletic performance has been widely explored. This study investigated the interactions between the polymorphisms ACTN3 (R577X), ACE (I/D), BDKRB2 (-9/+9), and AGT (M/T) and their association with endurance and strength phenotypes in Brazilian swimmers. Methods 123 athletes (aged 20–30 years) and 718 controls participated in the study. The athletes were divided into elite and sub-elite (N = 19 and 104, respectively) and strength and endurance experts (N = 98 and 25, respectively). Hardy-Weinberg equilibrium was observed in all groups. Results Considering the ACE polymorphism, it was observed a higher frequency of the DD genotype than expected in the strength experts of the elite group, whereas the strength experts sub-elite athletes had a higher frequency of the ID genotype (χ2 = 8.17; p = 0.01). Subjects with XX genotypes of ACTN3 are more likely to belong to the athlete group when compared to the control group (OR = 1.79, p = 0.04). The DD homozygotes of the ACE are more likely to belong to the elite group with strength phenotypes than the group of sub-elite (OR = 7.96, p = 0.01) and elite strength experts compared to elite endurance (OR = 18.0, p = 0.03). However, no significant differences were observed in the allelic distribution of the polymorphisms evaluated when comparing Elite, sub-elite athletes and controls. Conclusion ACE and ACTN3 allele frequencies should be considered with regard to performance influencing factors in Brazilian swimmers.

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The Impacts of ACE Activity according to ACE I/D Polymorphisms on Muscular Functions of People Aged 65

Cited by 9 publications

References 35 publications

Relationship of quadriceps muscle power and optimal shortening velocity with angiotensin-converting enzyme activity in older women

Relationship of quadriceps muscle power and optimal shortening velocity with angiotensin-converting enzyme activity in older women

Quadriceps muscle power and optimal shortening velocity are inversely related to angiotensin converting enzyme activity in older men

Association between ACTN3 (R577X), ACE (I/D), BDKRB2 (-9/+9), and AGT (M268T) polymorphisms and performance phenotypes in Brazilian swimmers

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