The impact of young age on the prognosis for colorectal cancer: a population-based study in Taiwan

Chou, Chia-Lin; Tseng, Chien-Jen; Shiue, Yow‐Ling

doi:10.1093/jjco/hyx110

Cited by 22 publications

(32 citation statements)

References 35 publications

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“…There are several studies showing that younger patients are living longer than older patients, 37 whereas others are showing opposite results. 38 In our study, age at diagnosis failed to show significance regarding OS ( P = .331).…”

Section: Discussioncontrasting

confidence: 56%

Treatment and Outcomes of Colorectal Cancer in Armenia: A Real-World Experience From a Developing Country

Bardakhchyan

Mkhitaryan²,

Zohrabyan

et al. 2020

JCO Global Oncology

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PURPOSE In Armenia, colorectal cancer (CRC) is one of the most frequently diagnosed cancers. It is in the third place by incidence. The aim of this study was to evaluate treatment and outcomes of CRC in Armenia during the last 9 years. MATERIALS AND METHODS For this retrospective hospital-based study, we have collected data from two main oncology centers in Armenia: National Oncology Center and “Muratsan” Hospital of Yerevan State Medical University. The information about patients with CRC who were treated at these two centers between January 1, 2010 and July 1, 2018 was collected from the medical records. Log-rank test and Kaplan-Meier curves were used for survival analysis. Prognostic factors were identified by Cox regression. RESULTS A total of 602 patients with CRC were involved in the final analysis. Median follow-up time was 37 months (range, 3-207 months). A total of 8.6% of patients had stage I, 32.9% stage II, 38.0% stage III, and 17.6% stage IV cancer; for 2.7% patients, the stage was unknown. The main independent prognostic factors for overall survival (OS) were tumor stage, grade, and histology. Adjuvant chemotherapy has been shown to improve survival in stage II colon cancer and stage III rectal but not in stage II rectal cancer. Radiotherapy did not yield survival improvement in stage II or III rectal cancer. Three- and 5-year OS rates were 62.9% and 51.8% for all stages combined and 79.7% and 68.5% for stages I-II, 62.5% and 48.4% for stage III, and 24.4% and 17% for stage IV respectively. CONCLUSION As seen from our results, our survival rates are lower than those of the developed world. Additional research is needed to identify the underlying reasons and to improve patients’ treatment and outcomes in Armenia.

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Section: Discussioncontrasting

confidence: 56%

Treatment and Outcomes of Colorectal Cancer in Armenia: A Real-World Experience From a Developing Country

Bardakhchyan

Mkhitaryan²,

Zohrabyan

et al. 2020

JCO Global Oncology

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“…Wang et al 37 studied 509,934 CRC patients from 3 databases (West China, SEER, and Linkoping Cancer) and reported that younger individuals (aged 50) had better survival despite having advanced disease compared to older individuals (aged > 50). However, in contrast, Chou et al 38 studied 62,060 CRC cases from a Taiwanese population and reported that individuals aged 40 had poor overall survival compared to those aged 41 to 70.…”

Section: Discussionmentioning

confidence: 94%

Rising Proportion of Young Individuals With Rectal and Colon Cancer

Kasi

Shahjehan

Cochuyt

et al. 2019

Clinical Colorectal Cancer

100

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We noticed an increased number of patients diagnosed with colorectal cancer (CRC) in their 20s, 30s, and 40s. We analyzed all CRC patients aged < 50 at our institutions from 1972 to 2017 and found increasing trends as well as a propensity for more distal location-findings that are hypothesis generating, given the embryologic origin of these tumors. This finding may have implications for screening guidelines. Background: Recent trends have identified increasing number of young individuals with rectal and colon cancers. These individuals, who are younger than 50 years old, in most instances would not meet screening guidelines. We aimed to report the characteristics and trend of the rising proportion of young individuals being diagnosed with rectal and colon cancers at our institutions. Patients and Methods: This study included 3381 rectal and colon cancer patients from the Mayo Clinic cancer registry from 1972 to 2017 who were diagnosed with rectal or colon cancer and who were < 50 years old. Patient and cancer characteristics are described. The Cochran-Armitage trend test was used to see if the change in percentage diagnosed at age < 50 years had a significant trend over the years. A linear regression model was fit to estimate the percentage change per year when the trend was approximately linear. Results: The percentage of patients diagnosed with rectal or colon cancer in different age categories over the years showed a rising trend for individuals aged < 50. Most of these tumors were distal (rectum, left-sided colon, and rightsided colon were 49.8%, 28.8%, and 21.4%, respectively). This was more so for patients < 50 diagnosed with rectal cancer, which showed a linear increase at a rate of 0.26% per year (P < .001). Conclusion: Our study affirms the rising proportion of colorectal cancers found in young individuals, with a linear ongoing rise of rectal cancers in particular. This may have implications for the current screening recommendations for colorectal cancers, which are already being revised.

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“…The particularly aggressive nature of SRCCs and its earlier onset in colorectal cancers has been highlighted in the literature [ 28 , 29 ]. These cancers have higher frequency of KRAS and BRAF mutations compared with conventional cancers [ 30 ], correlating to shorter overall survival [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Signet Ring Cell Adenocarcinomas

Benesch

Mathieson

2020

Cancers

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Signet ring cell adenocarcinomas (SRCCs) are a rare histological subtype of adenocarcinomas with a poor prognosis, typically due to advanced disease at diagnosis. A signet ring cell, mimicking its moniker, contains abundant intracytoplasmic mucin that pushes the nucleus to the periphery. In these cancers, this cell feature comprises more than 50% of the tumor. Despite predilection for the gastrointestinal tract, and in particular the stomach, primary SRCCs are also described in other sites, typically in case reports. This literature, however, lacks a standardized overview of the SRCC disease entity. Using a retrospective cohort approach, we summarize the clinicodemographic and mortality outcomes of SRCCs in thirteen primary sites, comprising 95% of all SRCCs in the Surveillance, Epidemiology, and End Results Program (SEER), a population-level cancer database covering nearly one-third of the United States population. SRCCs general trends compared to matching nonvariant adenocarcinomas are earlier age of onset, with initial presentation favoring higher rates of regional or distant disease presentation and poor tumor differentiation. After multivariable analysis, SRCCs typically have worse overall survivals, but substantial variances exist depending on tumor location. Identifying SRCCs at earlier disease stages is likely the single most important intervention to improving outcomes for these patients.

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The impact of young age on the prognosis for colorectal cancer: a population-based study in Taiwan

Cited by 22 publications

References 35 publications

Treatment and Outcomes of Colorectal Cancer in Armenia: A Real-World Experience From a Developing Country

Treatment and Outcomes of Colorectal Cancer in Armenia: A Real-World Experience From a Developing Country

Rising Proportion of Young Individuals With Rectal and Colon Cancer

Epidemiology of Signet Ring Cell Adenocarcinomas

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