The impact of weight change and measures of physical functioning on mortality

Underland, Lisa; Schnatz, Peter F.; Wild, Robert A.; Saquib, Nazmus; Shadyab, Aladdin H.; Allison, Matthew; Banack, Hailey R.; Wassertheil‐Smoller, Sylvia

doi:10.1111/jgs.17626

Cited by 7 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, there was significant association between one category of weight gain (> 5%) and the decreased risk of HTN. However, Underland et al (2022) in their study among 5,039 women with average age of 78.76 ± 6.92 found that weight gain was not associated with mortality or cardiovascular outcomes, however weight loss of 5% or more was associated with increased risk of mortality [ 43 ]. Women who experienced the surgical menopause might be at increased risk of coronary heart disease than women with natural menopause [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

To what extent the weight changes impact the risk of hypertension among menopausal women: insights from Tehran lipid and glucose study

Saei Ghare Naz,

Mousavi,

Noroozzadeh

et al. 2024

BMC Women's Health

View full text Add to dashboard Cite

Background & aim The association between weight change and incident hypertension (HTN) in menopausal women has not been well characterized. This study aimed to determine whether weight changes after menopausal years make a difference in incidents of hypertension. Materials & methods This population-based study was performed using data collected from Tehran Lipid and Glucose Study cohort (1999–2018). Women who had natural and early menopause were followed up every 3 years. Data gathering was performed through the standard protocol of the study. Statistical analysis was performed using multivariable Cox hazard regression analysis. We used the ‘survival’ package in the R software version 3.6.0 to fit survival models. Results A total of 487 menopausal women met the inclusion criteria; 62.6% had natural menopause and remained had early menopause. Among the participants, 65.5% experienced HTN. The highest proportion of participants had > 5% weight gain, while the lowest had 3–5% weight gain. Either losing body weight (lost > 5%: HR: 0.44; CI 95%, 0.32, 0.62; p < 0.001), (lost 3–5%; HR: 0.47; CI 95%, 0.26, 0.84; p = 0.01), and weight gain > 5% (HR: 0.69; CI 95%, 0.51, 0.91; p = 0.01), were associated with decreased risk of HTN after adjustment for confounders. In this study, weight loss and gain have a protective impact on the development of HTN in subjects. For incident HTN, age (HR: 1.04 (1.01, 1.08), p = 0.004), fasting blood glucose (HR: 1.01, CI 95%:1.00, 1.01; p < 0.001), body mass index (1.02 (1.00, 1.05), p = 0.03) and smoking (1.70 (1.11, 2.58), p = 0.01) were positively associated with HTN. Conclusions Our study indicates the significant association of weight change with hypertension risk in later life among menopausal women.

show abstract

Section: Discussionmentioning

confidence: 99%

To what extent the weight changes impact the risk of hypertension among menopausal women: insights from Tehran lipid and glucose study

Saei Ghare Naz,

Mousavi,

Noroozzadeh

et al. 2024

BMC Women's Health

View full text Add to dashboard Cite

show abstract

“…Previous studies have suggested that the mechanisms underlying the deleterious effects of weight change over certain lifespans may differ [ 9 , 21 ]. For example, in early adulthood, weight gain primarily results from the accumulation of fat mass [ 22 - 24 ], while in late adulthood, it is usually attributed to a decrease in lean body mass and an increase in fat mass [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Association between weight change and risk of liver fibrosis in adults with type 2 diabetes

Ke,

Xu,

Feng

et al. 2023

J Glob Health

View full text Add to dashboard Cite

Background Liver fibrosis plays a key role in the progression of non-alcoholic fatty liver disease to cirrhosis. Considering weight change is known to be closely associated with increased risk of liver fibrosis, we aimed to address a gap in evidence regarding the existence of this association in patients with type 2 diabetes (T2D). Methods We included data on 622 T2D patients and 1618 non-T2D participants from the 2017-2018 cycle of the National Health and Nutrition Examination Survey (NHANES). We assessed liver fibrosis by the median values of liver stiffness measurement (LSM). According to the participants' body mass index (BMI) at age 25 (early adulthood), 10 years prior (middle adulthood), and at the 2017-2018 cycle (late adulthood), we categorised weight change patterns into stable non-obese, weight loss, weight gain, and stable obese. We applied logistic regression to association analysis and used population attributable fraction (PAF) to analyses hypothetical prevention regimens. Results The prevalence of liver fibrosis was higher in T2D patients (23.04%) than in non-T2D participants (6.70%), while weight change was associated with a greater risk of fibrosis in the former compared to the latter group. Compared with T2D patients in the stable non-obese group, stable obese individuals from 10 years prior to the 2017-2018 cycle had the highest risk of developing liver fibrosis, corresponding to an adjusted odds ratio (aOR) of 3.13 (95% confidence interval = 1.84-5.48). Absolute weight change patterns showed that the risk of liver fibrosis was highest (aOR = 2.94) when T2D patients gained at least 20 kg of weight from 10 years prior to 2017-2018 cycle. Conclusions Obesity in middle and late adulthood is associated with an increased risk of T2D complicated with liver fibrosis.

show abstract

Nutrition Risk Is Associated with 3-Year Strength and Performance Indicators among Older Adults in the Canadian Longitudinal Study on Aging

Trinca,

Keller

2023

The Journal of nutrition, health and aging

View full text Add to dashboard Cite

The impact of weight change and measures of physical functioning on mortality

Cited by 7 publications

References 20 publications

To what extent the weight changes impact the risk of hypertension among menopausal women: insights from Tehran lipid and glucose study

To what extent the weight changes impact the risk of hypertension among menopausal women: insights from Tehran lipid and glucose study

Association between weight change and risk of liver fibrosis in adults with type 2 diabetes

Nutrition Risk Is Associated with 3-Year Strength and Performance Indicators among Older Adults in the Canadian Longitudinal Study on Aging

Contact Info

Product

Resources

About