The Impact of Vitiligo on Quality of Life and Psychosocial Well-Being in a Nepalese Population

Pun, Jenny; Randhawa, Aastha; Kumar, Ajay; Williams, Victoria

doi:10.1016/j.det.2020.08.011

Cited by 16 publications

(29 citation statements)

References 21 publications

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“…In contrast, the Vitiligo-specific QoL (VitiQoL) instrument has only been reported in eight studies [ 13 , 16 , 29 , 32 , 67 , 80 , 88 , 115 ] using our search parameters; half were published in the past year, of which two were clinical trials. There were no notable regional differences in VitiQoL scores among studies, which were conducted in each of the seven geographic regions, with two in North America.…”

Section: Resultsmentioning

confidence: 99%

“…Another instrument specific to vitiligo, the Vitiligo Impact Scale (VIS), was only used in three studies, with two published in the past year. One study used the original 27-item VIS [ 32 ], and two used the abbreviated 22-item scale (VIS-22) [ 36 , 100 ]; all studies were conducted in Southern Asian populations. Although the use of vitiligo-specific scales has increased recently, there remains an unmet need for a widely utilized, vitiligo-specific QoL instrument that has been validated in large interventional studies.…”

Section: Resultsmentioning

confidence: 99%

“…Depression and anxiety were the most commonly reported psychosocial comorbidities. Forty-one studies reported depression or depressive disorders (including major depressive disorder, bipolar disorder, and dysthymic disorder) in patients with vitiligo, with a prevalence range from 0.1–62.3% [ 15 , 17 , 22 , 23 , 28 , 30 , 32 , 34 , 35 , 39 , 40 , 43 , 44 , 46 , 48 , 50 , 57 , 68 , 69 , 71 , 92 , 100 , 104 , 113 – 115 , 131 , 137 , 138 , 142 , 143 , 145 , 146 , 150 , 154 , 155 , 158 – 160 , 163 , 177 ]. Twenty studies reported anxiety or anxiety-related disorders (including generalized anxiety disorder, agoraphobia, social phobia [not social avoidance], and panic disorder), with a prevalence of 1.9–67.9% [ 22 , 23 , 30 , 34 , 39 , 43 , 44 , 46 , 50 , 57 , 92 , 115 , 137 , 138 , 150 , 154 , 155 , 158 , 159 , 175 ].…”

Section: Resultsmentioning

confidence: 99%

“…|| Includes one study with a population in Jordan and Germany (n = 167). The number of patients in each country was not available in the published study; thus, the full population is included in both countries on this map [92], Georgia [159], Germany [104], India [22,28,43,100,113,114,137,138,143,145,146,150,177], Italy [142], Iran [30], Japan [163], Jordan [104], South Korea [71], Mexico [115], Nepal [32], Nigeria [44], Saudi Arabia [17,46,48,50], Singapore [68,69], Taiwan [23], Thailand [35], Turkey [34,39,57,155,158], UK [40,160], USA [ [173] comorbidity in vitiligo compared with other skin diseases.…”

Section: Mexicomentioning

confidence: 99%

“…Egypt[154], France[61], Germany[102,141], India[22,100,130,137,138,146], Nepal[32], Romania[109], Taiwan[23], Turkey [0 Germany[141], India[145], South Korea[56], Saudi Arabia[46], Taiwan[23], UK[40], USA[131][132][133] …”

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confidence: 99%

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Psychosocial Effects of Vitiligo: A Systematic Literature Review

et al. 2021

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Background Patients with vitiligo experience reduced quality of life. Objective To comprehensively describe the available evidence for psychosocial burden in vitiligo. Methods A systematic review of observational studies and clinical trials identified using PubMed, EMBASE, Scopus, and the Cochrane databases was performed through 1 March, 2021, to assess psychosocial comorbidities in vitiligo. Two independent reviewers performed an assessment of articles and extracted data for qualitative synthesis. Results Included studies (N = 168) were published between 1979 and 1 March, 2021; 72.6% were published since 2010. Disorders including or related to depression (41 studies, 0.1-62.3%) and anxiety (20 studies, 1.9-67.9%) were the most commonly reported. The most prevalent psychosocial comorbidities were feelings of stigmatization (eight studies, 17.3-100%), adjustment disorders (12 studies, 4-93.9%), sleep disturbance (seven studies, 4.6-89.0%), relationship difficulties including sexual dysfunction (ten studies, 2.0-81.8%), and avoidance or restriction behavior (12.5-76%). The prevalence of most psychosocial comorbidities was significantly higher vs healthy individuals. Factors associated with a significantly higher burden included female sex, visible or genital lesions, age < 30 years (particularly adolescents), and greater body surface area involvement, among others. The most commonly reported patient coping strategy was lesion concealment. Limitations Available studies were heterogeneous and often had limited details; additionally, publication bias is possible. Conclusions The results of this systematic review show that vitiligo greatly affects psychosocial well-being. The extent of psychosocial comorbidities supports the use of multidisciplinary treatment strategies and education to address the vitiligoassociated burden of disease. Protocol Registration PROSPERO (CRD42020162223).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Mexicomentioning

confidence: 99%

mentioning

confidence: 99%

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Psychosocial Effects of Vitiligo: A Systematic Literature Review

et al. 2021

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Psychosocial impact of vitiligo in patients with skin of color

Mehta

Gupta

2022

Dermatological Reviews

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Vitiligo exerts a significant negative effect on patients' quality of life. Patients with skin of colour have a more negative attitude towards vitiligo than those with fairer skin. Many myths and misconceptions about vitiligo are prevalent in certain societies in South-east Asia and the middle east. Confusion with leprosy further adds to the stigma. Vitiligo impacts several spheres of life due to the cosmetic disfigurement as well as the prevailing socio-cultural factors. Patients with vitiligo suffer from low self-esteem, and often face discrimination, and difficulties in social life and relationships. Quality-of-life measures such as Dermatology Life Quality Index and Vitiligo Impact Scale-22 indicate that vitiligo has a moderate-to-large effect on patients' life. Psychiatric comorbidities such as anxiety and depression are more prevalent among patients with vitiligo as compared to general population. The psychosocial burden of vitiligo should be evaluated separately from the clinical severity separately because it may not correlate with the extent of depigmentation, and may not improve in proportion to the repigmentation. Apart from the treatment of vitiligo patches, patients may benefit from measures specifically aimed at reducing the psychosocial distress.

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Quality of life, disease burden and healthcare need of patients with vitiligo

Augustin,

Gewiss,

Ben-Anaya

et al. 2024

Dermatologie

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Zusammenfassung Hintergrund Vitiligo ist mit einer Prävalenz von 0,5–2,0 % eine der weltweit häufigsten Hauterkrankungen mit einem Verlust des Pigments. Die Hauterkrankung hat einen entstellenden, oft stigmatisierenden Charakter und ist oft mit psychosozialen Belastungen assoziiert. Zielsetzung Es erfolgt eine Übersicht über die psychosoziale Beeinträchtigung, Krankheitslast und den resultierenden Versorgungsbedarf von Patienten mit Vitiligo. Material und Methoden Es handelt sich um eine narrative Übersichtsarbeit auf der Grundlage einer Literaturrecherche in PubMed für die Jahre 1996 bis 2022 zu den Themen Krankheitslast, Lebensqualität und Stigmatisierung. Ergebnisse Die Recherche ergab für den Suchzeitraum 175 relevante Originalarbeiten inklusive klinischer Studien, Metaanalysen und systematischer Übersichtsarbeiten (n = 65). Dabei dokumentiert eine Vielzahl an Studien, dass Vitiligo bei den Betroffenen mit erheblichen psychosozialen Belastungen und relevanten Einbußen an Lebensqualität einhergeht. Problembereiche betreffen insbesondere Stigmatisierung, sexuelle Funktionsstörungen, Angst, vermindertes Selbstwertgefühl und Probleme im Beruf. Das beobachtete erhöhte Ausmaß von Angst und Depressionen korreliert mit der Schwere und Aktivität der Vitiligo. Oft trägt auch Komorbidität zur weiteren Krankheitslast bei. Diese Faktoren determinieren bei einem relevanten Teil der Betroffenen einen hohen Versorgungsbedarf. Diskussion Die Vitiligo stellt nicht in erster Linie ein kosmetisches Problem dar, sondern eine behandlungsbedürftige Erkrankung im Sinne der Definition der Weltgesundheitsorganisation von Gesundheit als körperliches, geistiges und soziales Wohlbefinden. Die Nutzen von Behandlungsoptionen sind an ihren Effekten auf patientenberichtete Endpunkte zu messen. Graphic abstract

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The Impact of Vitiligo on Quality of Life and Psychosocial Well-Being in a Nepalese Population

Cited by 16 publications

References 21 publications

Psychosocial Effects of Vitiligo: A Systematic Literature Review

Psychosocial Effects of Vitiligo: A Systematic Literature Review

Psychosocial impact of vitiligo in patients with skin of color

Quality of life, disease burden and healthcare need of patients with vitiligo

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