The impact of vitamin D receptor gene polymorphism (rs2228570) in osteoarthritis in Iraqi women

Hadi, Shaymaa M.

doi:10.1016/j.genrep.2022.101561

Cited by 2 publications

(2 citation statements)

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“…Careful screening of studies that have analysed the relationship between the VDR gene polymorphisms and elevated risk of HT among Iraqi populations has identi ed studies that have investigated the relationship of these polymorphisms with polycystic ovary syndrome (Hamdi et al, 2018), breast cancer (Haddad et al, 2020), thalassemia (Abbas et al, 2020) (Hadi et al, 2022). One previous study examined the relationship between FokI and TaqI gene polymorphisms and the risk of HT in the Iraqi population, and reported that individuals with dominant homozygous FF of FokI and TT of TaqI were more susceptible to the disease, while individuals with Ff heterozygous of FokI and Tt of TaqI were more protected (Majid et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of vitamin D receptor gene and the risk of Hashimoto's thyroiditis: an Iraqi case-control study

Majid

Abulrazzaq

Al-Koofee

et al. 2023

Preprint

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Background Recently, the vitamin D receptor gene polymorphisms has been linked to various autoimmune diseases. The key aim of this study is to explore the association between VDR gene polymorphisms (rs2228570, rs1544410, rs731236, rs7975232) and the risk of Hashimoto's thyroiditis (HT) among the Iraqi population. Methods Peripheral blood samples were used to isolate genomic DNAs from 180 HT patients and 200 healthy controls. Four VDR gene loci were amplified, and the obtained amplicons were then digested using the restriction enzymes FokI, BsmI, TaqI and ApaI. The digested fragments were then electrophoresed on agarose gel (2.5%). HT polymorphisms and estimated haplotypes were computed by odds ratios (ORs). Results After stratification by age, gender and body mass index (BMI), univariate logistic regression statistical analysis revealed a significantly higher incidence of FokI (rs2228570) polymorphisms in HT patients compared to healthy controls. In contrast, the incidence of the BsmI (rs1544410) and TaqI (rs731236) polymorphisms were significantly higher in healthy controls than in the HT patient group. Linkage disequilibrium (LD) analysis of pairs of SNPs revealed that the polymorphisms in the VDR gene (rs731236 A/G and rs7975232 G/C) were in strong LD in an HT model (D’= 0.86). Furthermore, AAGC and AAGT haplotype models (OR = 1.50, 95% CI: 1.09 − 2.07; OR = 1.61, 95% CI: 1.06 − 2.45, P = 0.02) were associated with an increased risk of HT, while the AACC haplotype model (OR = 0.37, 95% CI: 0.15–0.90, P = 0.02) exhibited a significantly decreased the risk of developing HT. Conclusion Our research supports the association between HT and the FokI polymorphism among the Iraqi population. In addition, the haplotype analysis reveals that the combination of mutant alleles from several VDR gene polymorphisms makes these individuals more susceptible to HT.

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Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of vitamin D receptor gene and the risk of Hashimoto's thyroiditis: an Iraqi case-control study

Majid

Abulrazzaq

Al-Koofee

et al. 2023

Preprint

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“…Muscle weakness, a greater chance of falling and poor energy fractures are all significant outcomes. In different regions of the world, vitamin D insufficiency is more common than in others (Hadi, 2022).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D, calcium and caffeine intake relationship to bone mineral density

Mubarak

Ahmed

Hussein

et al. 2023

AGJSR

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PurposeThis study aims to evaluate the caffeinated drinks, levels of vitamin D and calcium in the blood, and their relationship to bone mineral density (BMD) in osteoporotic women in Al-Ahsa Saudi Arabia.Design/methodology/approachThis study included 85 women over approximately 18 months with ages ranging from 40 to 70 years who were evaluated in the laboratory via blood analysis. Moreover, sociodemographic data and information on health and nutritional awareness were collected via a questionnaire. The BMD was measured by dual-energy X-ray absorptiometry (DXA) and considered osteopenia when the T value total of the lumbar spine or hip was between −1 and −2.5 and osteoporosis < −2.5. Blood levels of vitamin D and calcium were measured via blood analysis.FindingsThere were 54.1% and 45.9% of women who suffered from osteoporosis and low BMD, respectively. There was a significant difference in the number of osteoporotic, and low bone mineral mass groups in marital status (p = 0.04), but no difference was found in age and educational level. A significant difference (p = 0.01) between low bone mass and osteoporosis groups in heights. BMD was significantly and negatively correlated with vitamin D in the blood in individuals with osteoporosis (r = −0.358, P = 0.014). In addition, there was a significant negative correlation between calcium in the blood and total samples (r = −0.355, P = 0.0578). There was a negative significant relationship between calcium supplements and BMD in individuals with low BMD (rt = −0.279, P = 0.041). There was a significant association between cola intake with the occurrence of low BMD (p = 0.027), whereas tea drinking was not associated with risk in both groups.Originality/valueThe study indicated that there is a direct relationship between osteoporosis and low bone mass with different variables. This study was conducted to address the lack of research related to the levels of vitamin D and calcium in the blood and their relationship with BMD in women with low BMD and osteoporosis in Al-Ahsa province-KSA.

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The impact of vitamin D receptor gene polymorphism (rs2228570) in osteoarthritis in Iraqi women

Cited by 2 publications

References 26 publications

Genetic polymorphisms of vitamin D receptor gene and the risk of Hashimoto's thyroiditis: an Iraqi case-control study

Genetic polymorphisms of vitamin D receptor gene and the risk of Hashimoto's thyroiditis: an Iraqi case-control study

Vitamin D, calcium and caffeine intake relationship to bone mineral density

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