The impact of vitamin D deficiency on neurogenesis in the adult brain

Groves, Natalie J.

doi:10.4103/1673-5374.202936

Cited by 32 publications

(7 citation statements)

References 12 publications

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“…41,42 It is possible that higher levels of 25(OH)D will enable vitamin D to play a role in neuro-immunomodulation, neurotransmission, antioxidation, and gene regulation in behavioral and neuropsychiatric disorders. [43][44][45] Cannell et al , recommended the ideal level of 25(OH)D ranged from 55 to 70 ng/mL for supplemental treatment of chronic disorders with vitamin D deficiency. 43 Therefore, our study chose to give vitamin D3 supplementation at a dose of 300 IU/kg/d (no more than 5000 IU/d) in order to reach the ideal 25(OH)D level of 55-70 ng/mL.…”

Section: Discussionmentioning

confidence: 99%

<p>Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders</p>

Wang

et al. 2019

NDT

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Purpose: Vitamin D deficiency has been found in children with chronic tic disorders (CTDs). Our previous data showed that serum 25-hydroxyvitamin D [25(OH)D] level in children with CTDs was lower than that of the healthy controls and lower serum 25(OH)D level was associated with increased severity of the tic disorder. Thus, we intend to further verify this phenomenon and examine the effect of vitamin D3 on CTDs. Patients and methods: In total, 120 children with CTDs and 140 normal controls were enrolled in this study, with 36/120 of those in the CTD group receiving vitamin D3 treatment for 3 months. The Yale Global Tic Severity Scale (YGTSS) and Clinical Global Impression of Severity of Illness (CGI-SI) were, respectively, used to evaluate the tic severity. High-performance liquid chromatography and tandem mass spectrometry were used to measure serum 25(OH)D level. Results: Those children with CTDs exhibited significantly lower 25(OH)D levels than did healthy controls, and these reduced 25(OH)D levels were linked to increasing severity of tic symptoms. After treatment with supplemental vitamin D3, serum 25(OH)D level and scores of YGTSS total, motor tics, phonic tics, total tic, impairment, and CGI-SI improved significantly in children with CTDs without any adverse reactions. Conclusion: Supplementation vitamin D3, given its low cost and excellent safety, may be an effective means of improving symptoms in certain children with CTDs.

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Section: Discussionmentioning

confidence: 99%

<p>Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders</p>

Wang

et al. 2019

NDT

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“…Furthermore, VD3 completely reversed the increased immobility time demonstrated in the non-treated 6-OHDA group, indicating an antidepressive-like behavior. VD3 deficiency has been related with a reduced immobility time, on the forced swimming test [ 38 ]. Low VD3 concentrations in the blood seem to be associated with adult depression and postpartum depression [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D protects dopaminergic neurons against neuroinflammation and oxidative stress in hemiparkinsonian rats

Lima

Lopes

Costa

et al. 2018

J Neuroinflammation

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BackgroundThe deficiency in 1α, 25-dihydroxyvitamin D3 (VD3) seems to increase the risk for neurodegenerative pathologies, including Parkinson’s disease (PD). The majority of its actions are mediated by the transcription factor, VD3 receptor (VD3R).MethodsThe neuroprotective effects of VD3 were investigated on a PD model. Male Wistar rats were divided into the following groups: sham-operated (SO), 6-OHDA-lesioned (non-treated), and 6-OHDA-lesioned and treated with VD3 (7 days before the lesion, pre-treatment or for 14 days after the 6-OHDA striatal lesion, post-treatment). Afterwards, the animals were subjected to behavioral tests and euthanized for striatal neurochemical and immunohistochemical assays. The data were analyzed by ANOVA and the Tukey test and considered significant for p < 0.05.ResultsWe showed that pre- or post-treatments with VD3 reversed behavioral changes and improved the decreased DA contents of the 6-OHDA group. In addition, VD3 reduced the oxidative stress, increased (TH and DAT), and reduced (TNF-alpha) immunostainings in the lesioned striata. While significant decreases in VD3R immunoreactivity were observed after the 6-OHDA lesion, these changes were blocked after VD3 pre- or post-treatments. We showed that VD3 offers neuroprotection, decreasing behavioral changes, DA depletion, and oxidative stress. In addition, it reverses partially or completely TH, DAT, TNF-alpha, and VD3R decreases of immunoreactivities in the non-treated 6-OHDA group.ConclusionsTaken together, VD3 effects could result from its anti-inflammatory and antioxidant actions and from its actions on VD3R. These findings should stimulate translational research towards the VD3 potential for prevention or treatment of neurodegenerative diseases, as PD.Electronic supplementary materialThe online version of this article (10.1186/s12974-018-1266-6) contains supplementary material, which is available to authorized users.

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“…Equally, depressive symptoms might result in lower motivation to go outdoors and thus lower levels of vitamin D. However, the prospective associations described in the current study support the notion that vitamin D deficiency and insufficiency predate the development of depression, and there are a number of potential direct biological mechanisms through which vitamin D might Psychological Medicine 5 play a role in this development. Vitamin D has been shown to regulate the expression of important neurotrophic factors involved in the proliferation, differentiation, survival and growth of neurons (Groves & Burne, 2017), and is known to be neuroprotective, preventing oxidative damage to nervous tissue (Wrzosek et al, 2013). There is also in vitro evidence that vitamin D maintains extracellular concentrations of serotonin in the brain (Sabir et al, 2018), a neurotransmitter central to the development of depression.…”

Section: Discussionmentioning

confidence: 99%

Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort

et al. 2020

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Background A possible role of vitamin D in the pathophysiology of depression is currently speculative, with more rigorous research needed to assess this association in large adult populations. The current study assesses prospective associations between vitamin D status and depression in middle-aged adults enrolled in the UK Biobank. Methods We assessed prospective associations between vitamin D status at the baseline assessment (2006–2010) and depression measured at the follow-up assessment (2016) in 139 128 adults registered with the UK Biobank. Results Amongst participants with no depression at baseline (n = 127 244), logistic regression revealed that those with vitamin D insufficiency [adjusted odds ratio (aOR) = 1.14, 95% confidence interval (CI) = 1.07–1.22] and those with vitamin D deficiency (aOR = 1.24, 95% CI 1.13–1.36) were more likely to develop new-onset depression at follow-up compared with those with optimal vitamin D levels after adjustment for a wide range of relevant covariates. Similar prospective associations were reported for those with depression at baseline (n = 11 884) (insufficiency: aOR = 1.11, 95% CI 1.00–1.23; deficiency: aOR = 1.30, 95% CI 1.13–1.50). Conclusions The prospective associations found between vitamin D status and depression suggest that both vitamin D deficiency and insufficiency might be risk factors for the development of new-onset depression in middle-aged adults. Moreover, vitamin D deficiency (and to a lesser extent insufficiency) might be a predictor of sustained depressive symptoms in those who are already depressed. Vitamin D deficiency and insufficiency is very common, meaning that these findings have significant implications for public health.

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The impact of vitamin D deficiency on neurogenesis in the adult brain

Cited by 32 publications

References 12 publications

<p>Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders</p>

<p>Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders</p>

Vitamin D protects dopaminergic neurons against neuroinflammation and oxidative stress in hemiparkinsonian rats

Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort

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