The impact of vitamin D supplementation on serum cathelicidin levels and the clinical course of atopic dermatitis in children

Tsotra, Kyriaki; Garoufi, Anastasia; Kossiva, Lydia; Gourgiotis, Dimitrios; Tsoukatou, Theano; Katsantoni, Eleni; Stavropoulos, Panagiotis

doi:10.23736/s2724-5276.17.04910-6

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Data from the studies analyzed suggested a potential role for several antioxidant molecules including vitamin D, vitamin E, vitamin A and melatonin. The most promising role seems to be played by vitamin D, with several studies indicating its possible therapeutic use in AD ( 26 , 30 , 32 , 75 ). In particular, there is one RCT study conducted on 60 patients in which significant improvement was observed in patients treated with 1,600 IU of vitamin D for 60 days.…”

Section: Discussionmentioning

confidence: 99%

“…Levels of vitamin D, determined by the chemiluminescence method, were significantly higher in patients with mild disease than in those with moderate or severe disease ( 74 ). Furthermore, in a prospective observational study conducted by Tsotra et al 50 children were enrolled, and a statistically significant reduction in SCORAD was observed after 20 weeks of treatment in children who had received 2,400 IU of vitamin D. Specifying that the reduction becomes nonstatistically significant after 45 days and at the end of treatment ( 75 ).…”

Section: Antioxidant Agentsmentioning

confidence: 99%

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Role of antioxidants supplementation in the treatment of atopic dermatitis: a critical narrative review

De Simoni,

Candelora,

Belleggia

et al. 2024

Front. Nutr.

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Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by itching, epidermal barrier dysfunction, and an unbalanced inflammatory reaction. AD pathophysiology involves a dysregulated immune response driven by T helper-2 cells. Many factors, including reactive oxygen species (ROS), are involved in AD pathogenesis by causing cellular damage and inflammation resulting in skin barrier dysfunction. This narrative review aims to provide a comprehensive overview of the role of natural molecules and antioxidant compounds, highlighting their potential therapeutic value in AD prevention and management. They include vitamin D, vitamin E, pyridoxine, Vitamin C, carotenoids, and melatonin. Some studies report a statistically significant association between antioxidant levels and improvement in AD, however, there are conflicting results in which antioxidant supplementation, especially Vitamin D, did not result in improvement in AD. Therefore, the clinical efficacy of these dietary nutritional factors in the treatment of AD needs to be further evaluated in clinical trials. Meanwhile, antioxidants can be incorporated into the management of AD patients in a personalized manner, tailored to the severity of the disease, comorbidities, and individual needs.

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Section: Discussionmentioning

confidence: 99%

Section: Antioxidant Agentsmentioning

confidence: 99%

Role of antioxidants supplementation in the treatment of atopic dermatitis: a critical narrative review

De Simoni,

Candelora,

Belleggia

et al. 2024

Front. Nutr.

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The role of cathelicidins in neutrophil biology

Yoon,

Puentes,

Tran

et al. 2024

Journal of Leukocyte Biology

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Despite their relatively short lifespan, neutrophils are tasked with counteracting pathogens through various functions, including phagocytosis, production of reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and host defence peptides. Regarding the latter, small cationic cathelicidins present a conundrum in neutrophil function. Although primarily recognized as microbicides with an ability to provoke pores in microbial cell walls, the ability of cathelicidin to modulate key neutrophil functions is also of great importance, including the release of chemo-attractants, cytokines and ROS, plus prolonging neutrophil lifespan. Cumulative evidence indicates a less recognized role of cathelicidin as an “immunomodulator;” however, this term is not always explicit and its relevance in neutrophil responses during infection and inflammation is seldom discussed. This review compiles and discusses studies of how neutrophils use cathelicidin to respond to infections, while also acknowledging immunomodulatory aspects of cathelicidin through potential crosstalk between sources of the peptide.

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Vitamin D Deficiency and Effects of Vitamin D Supplementation on Disease Severity in Patients with Atopic Dermatitis: A Systematic Review and Meta-Analysis in Adults and Children

et al. 2019

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Research has investigated 25-hydroxyvitamin D (25(OH)D) levels in the Atopic Dermatitis (AD) population, as well as changes in AD severity after vitamin D (VitD) supplementation. We performed an up-to-date systematic review and meta-analysis of these findings. Electronic searches of MEDLINE, EMBASE and COCHRANE up to February 2018 were performed. Observational studies comparing 25(OH)D between AD patients and controls, as well as trials documenting baseline serum 25(OH)D levels and clinical severity by either SCORAD/EASI scores, were included. Of the 1085 articles retrieved, sixteen were included. A meta-analysis of eleven studies of AD patients vs. healthy controls (HC) found a mean difference of −14 nmol/L (95% CI −25 to −2) for all studies and −16 nmol/L (95% CI −31 to −1) for the paediatric studies alone. A meta-analysis of three VitD supplementation trials found lower SCORAD by −11 points (95% CI −13 to −9, p < 0.00001). This surpasses the Minimal Clinical Important Difference for AD of 9.0 points (by 22%). There were greater improvements in trials lasting three months and the mean weighted dose of all trials was 1500–1600 IU/daily. Overall, the AD population, especially the paediatric subset, may be at high-risk for lower serum 25(OH)D. Supplementation with around 1600 IU/daily results in a clinically meaningful AD severity reduction.

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The impact of vitamin D supplementation on serum cathelicidin levels and the clinical course of atopic dermatitis in children

Cited by 3 publications

References 14 publications

Role of antioxidants supplementation in the treatment of atopic dermatitis: a critical narrative review

Role of antioxidants supplementation in the treatment of atopic dermatitis: a critical narrative review

The role of cathelicidins in neutrophil biology

Vitamin D Deficiency and Effects of Vitamin D Supplementation on Disease Severity in Patients with Atopic Dermatitis: A Systematic Review and Meta-Analysis in Adults and Children

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