The impact of vatinoxan on microcirculation after intramuscular co-administration with medetomidine in Beagle dogs: a blinded crossover study

Effects of acepromazine and dexmedetomidine, followed by propofol induction and maintenance with isoflurane anaesthesia, on the microcirculation of Beagle dogs evaluated by sidestream dark field imaging: an experimental trial

“…We cannot compare our values of microcirculatory variables directly with a former study in dogs assessing the effects of 1 mg m e2 body surface area medetomidine IM with laser Doppler, as different techniques and software were used (Pypendop & Verstegen 2000). However, we can argue that the dose of dexmedetomidine was much lower in our study than the medetomidine dose in the studies of Pypendop & Verstegen (2000) and Niemann et al (2022) and therefore we found different effects on microcirculation. Additionally, we administered acepromazine, which probably led to vasodilation and consequently to a higher Perfused de Backer density.…”

“…However, this might not be true if higher drug doses are to be used or in a pathological situation (e.g., sepsis). In a recent study of Niemann et al (2022), the administration of 1 mg m e2 (approximately 50 mgk g e1 ) medetomidine IM caused a significant decrease in the Proportion of perfused vessels. The co-administration of 20 mg kg e1 vatinoxan in the same dogs led to smaller changes.…”

Assessment of the microvascular perfusion using sidestream dark‐field imaging in healthy newborn foals

“…In veterinary medicine, several studies have described the use of SDF and other similar technologies applied to oral mucosa in pigs (Erces et al., 2011 ; Guglielmi et al, 2004 ; Wester et al., 2011 ), dogs (Niemann et al., 2022 ; Silverstein et al., 2009 ; Silverstein et al., 2014), and cats (Goodnight et al., 2015 ; Yozova et al, 2022 ). In addition, microcirculatory imaging has been evaluated in conscious or anesthetized healthy and sick adult horses using the rectal, colonic, or oral mucosa, with some promising results for detecting microcirculatory alterations in different conditions (Croxford et al., 2013 ; Hallowell et al., 2013 ; Hurcombe et al., 2014 ; Kieffer et al., 2018 ; Mansour et al., 2021 ).…”