The Impact of Uric Acid on Long-term Mortality in Patients with Asymptomatic Carotid Atherosclerotic Disease

Mayer, Florian; Mannhalter, Christine; Minar, Erich; Schillinger, Martin; Chavakis, Triantafyllos; Siegert, Gabriele; Arneth, Borros; Koppensteiner, Renate; Hoke, M.

doi:10.1016/j.jstrokecerebrovasdis.2014.08.035

Cited by 6 publications

(1 citation statement)

References 32 publications

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“…In this meta-analysis, uric acid levels were related to an increase in the recurrence rate of ischemic stroke (p < 0.001). The relationship between serum uric acid and ischemic stroke is consistent with past studies [21][22][23]. Similar to our study, a research suggested that there is a link between high serum uric acid (SUA) levels and the danger of hypertension, cardiovascular disease (CVD) and ischemic stroke [24,25].…”

Section: Discussionsupporting

confidence: 92%

Serum Uric Acid Levels and Recurrence Rate of Ischemic Stroke: A Meta-Analysis

Wang

Gao

2023

Horm Metab Res

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The role of serum uric acid as a factor in the recurrence of ischemic stroke stays unclear. Several studies have examined the relationship between serum uric acid and recurrence of acute ischemic stroke, with various results. Therefore, we carried out a meta-analysis to have a look at the relationship between serum uric acid levels and the potential danger of stroke recurrence in patients with ischemic stroke. Relevant experiments have been recognized via looking out the electronic databases and conference sessions. This present study included a case-control study of the impact of uric acid on the recurrence of ischemic stroke. After the assessment of eligibility, this meta-analysis included four articles in which 2452 patients with ischemic stroke were tested for their level of serum uric acid. The results obtained from this meta-analysis confirmed that improved uric acid concentrations were extensively and independently related to an accelerated and higher risk of recurrent stroke. The pooled OR (95% CI) was 1.80 (1.47, 2.20) (p<0.001). Overall, this meta-analysis shows a relationship between uric acid concentration and stroke recurrence rate. Furthermore, high uric acid levels could enhance the recurrence rate of ischemic stroke.

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Section: Discussionsupporting

confidence: 92%

Serum Uric Acid Levels and Recurrence Rate of Ischemic Stroke: A Meta-Analysis

Wang

Gao

2023

Horm Metab Res

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Gout

Durme

Landewé

2017

The Heart in Rheumatic, Autoimmune and Inflammatory Diseases

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Serum uric acid and risk of cardiovascular mortality: a systematic review and dose-response meta-analysis of cohort studies of over a million participants

Rahimi-Sakak

Maroofi

Rahmani

et al. 2019

BMC Cardiovasc Disord

109

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Background Cardiovascular disease (CVD) is the leading cause of death worldwide. Some studies have suggested anassociation between serum uric acid levels and cardiovascular mortality; however, the results have not been summarized in a meta-analysis. Methods A comprehensive search of all related studies until April 2018was performed in MEDLINE/PubMed and Scopus databases DerSimonianand Laird random-effects models were used to combine hazard ratios (HRs) with 95% confidence intervals (CIs). Dose-response analysis was also carried out. Results Thirty-two studies containing forty-four arms with 1,134,073 participants reported association between uric acid and risk of CVD mortality were included in our analysis. Pooled results showed a significant positive association between uric acid levels and risk of CVD mortality (HR 1.45, 95% CI 1.33–1.58, I2 = 79%). Sub-group analysis showed this relationshipwasstronger in women compared to men. Moreover, there was a significant non-linear association between uric acid levels and the risk of CVD mortality (r = 0.0709, p = 0.001). Conclusion Our analysis indicates a positive dose-response association between SUA and CVD mortality risk.

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The Impact of Uric Acid on Long-term Mortality in Patients with Asymptomatic Carotid Atherosclerotic Disease

Cited by 6 publications

References 32 publications

Serum Uric Acid Levels and Recurrence Rate of Ischemic Stroke: A Meta-Analysis

Serum Uric Acid Levels and Recurrence Rate of Ischemic Stroke: A Meta-Analysis

Gout

Serum uric acid and risk of cardiovascular mortality: a systematic review and dose-response meta-analysis of cohort studies of over a million participants

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