The Impact of Type 2 Diabetes on the Development of Hepatocellular Carcinoma in Different Viral Hepatitis Statuses

Wang, Chong Shan; Yao, Wei Jen; Chang, Ting Tsung; Wang, Shan Tair; Chou, Pesus

doi:10.1158/1055-9965.epi-08-1131

Cited by 94 publications

(110 citation statements)

References 36 publications

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“…The potential relationship between HCV infection and the development of DM increases the need for the implementation of prevention measures. Prevention must be directed toward lifestyle changes that can reduce the risk of HCV infection and/or diabetes development [266] ; regular diabetes screening for anti-HCV-positive people; and the analysis of other risk factors that can accelerate the progression of both CHC and DM, such as obesity, dyslipidaemia, and alcohol consumption. In these high-risk patients, comprehensive treatment, including lifestyle modifications, must be recommended.…”

Section: Prevention and Treatmentmentioning

confidence: 99%

Hepatitis C virus infection and type 1 and type 2 diabetes mellitus

Antonelli

Ferrari

Giuggioli

et al. 2014

WJD

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cytokines, chemokines, and other immune-mediated mechanisms. Few data have been reported on the association of CHC and T1DM and reports on the potential association between T1DM and acute HCV infection are even rarer. A small number of studies indicate that interferon-α therapy can stimulate pancreatic autoimmunity and in certain cases lead to the development of T1DM. Diabetes and CHC have important interactions. Diabetic CHC patients have an increased risk of developing cirrhosis and hepatocellular carcinoma compared with non-diabetic CHC subjects. However, clinical trials on HCV-positive patients have reported improvements in glucose metabolism after antiviral treatment. Further studies are needed to improve prevention policies and to foster adequate and cost-effective programmes for the surveillance and treatment of diabetic CHC patients. AbstractHepatitis C virus (HCV) infection and diabetes mellitus are two major public health problems that cause devastating health and financial burdens worldwide. Diabetes can be classified into two major types: type 1 diabetes mellitus (T1DM) and T2DM. T2DM is a common endocrine disorder that encompasses multifactorial mechanisms, and T1DM is an immunologically mediated disease. Many epidemiological studies have shown an association between T2DM and chronic hepatitis C (CHC) infection. The processes through which CHC is associated with T2DM seem to involve direct viral effects, insulin resistance, proinflammatory Submit a

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Section: Prevention and Treatmentmentioning

confidence: 99%

Hepatitis C virus infection and type 1 and type 2 diabetes mellitus

Antonelli

Ferrari

Giuggioli

et al. 2014

WJD

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“…The association between chronic HCV infection and increased prevalence of IR and type 2 diabetes mellitus (DM) was extensively reported [4]. IR was reported to accelerate fibrosis in chronic HCV-infected patients [5,6], which may lead to increased risk of cirrhosis and hepatocellular carcinoma [7] and has been associated with reduced rate of sustained virological response (SVR) in response to pegylated interferon (IFN)-α and ribavirin therapy [8]. …”

Section: Introductionmentioning

confidence: 99%

Study of changes in lipid profile and insulin resistance in Egyptian patients with chronic hepatitis C genotype 4 in the era of DAAs

Sagheer

Soliman

Ahmad

et al. 2018

Libyan Journal of Medicine

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Chronic hepatitis C virus (HCV) infection is associated with altered metabolism, including dyslipidemia and insulin resistance. These contribute to disease progression and influences the response to therapy. To investigate the relationships of new direct-acting antiviral drugs, simeprevir/sofosbuvir, with lipid profile and insulin resistance (IR). Eighty chronic hepatitis C genotype 4 patients were included; they were divided into four groups according to the severity of fibrosis as detected by fibroscan. Forty healthy persons volunteered as a control group. Lipid profile changes and IR were analyzed at baseline and after the end of treatment, and any effect of these changes on the response to treatment was studied. Before treatment, the levels of serum triglycerides were significantly higher in patients than in the control, and the levels of fasting insulin showed a progressive increase with advancing stage of fibrosis. At the end of treatment, there were a significant reduction in serum triglycerides, FBS, fasting insulin, and homeostasis model for the assessment of IR (P < 0.001), and a significant elevation of serum cholesterol and low-density lipoprotein (LDL)-c, high-density lipoprotein (HDL)-c, and LDL/HDL ratio (P = 0.001). An end-of-treatment response (week 12) was achieved in (99%) of the treated cases with 99% sustained viral response for 12 weeks post-treatment (week 24). Significant lipid profile changes were detected at the end of treatment. Serum lipid levels and IR are no longer predictors of response to DAAs. Follow-up of the lipid profile is warranted to avoid any possible remote effect of atherosclerotic heart disease.

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“…Some are known, including additional disease processes and genetic polymorphisms, but many and perhaps most are less well understood. As a known example, the metabolic syndrome is both a contributing factor for hepatocellular carcinoma in patients with chronic viral hepatitis C-associated cirrhosis [ 1 ] and an independent risk factor for hepatocellular carcinoma through steatohepatitis-induced cirrhosis [ 2 ]. Alcohol use and hepatic siderosis are additional cofactors that contribute to cancer development in cirrhotic livers from many different causes.…”

Section: Clinical Featuresmentioning

confidence: 99%

Hepatocellular Carcinoma

Torbenson¹

2015

Surgical Pathology of Liver Tumors

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Hepatocellular carcinoma is the most common primary malignant tumor of the liver. Although usually morphologically distinct, hepatocellular carcinomas can demonstrate various histologic patterns, which sometimes create diagnostic challenges for the surgical pathologist. In addition, a number of subtypes are discussed in this chapter, along with typical hepatocellular carcinoma. This chapter examines the clinical, gross, and microscopic features of hepatocellular carcinoma and its variants with illustrated examples. The differential diagnosis of hepatocellular carcinoma is also covered, with a detailed discussion of the various special stains used in the diagnosis of hepatocellular carcinoma and their respective utilities and limitations. Important prognostic factors, including grading of hepatocellular carcinoma, are also reviewed.

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The Impact of Type 2 Diabetes on the Development of Hepatocellular Carcinoma in Different Viral Hepatitis Statuses

Abstract: Background: The risk of type 2 diabetes on the development of hepatocellular carcinoma remains inconclusive in different hepatitis statuses. Methods: We prospectively followed a community-

Cited by 94 publications

References 36 publications

Hepatitis C virus infection and type 1 and type 2 diabetes mellitus

Hepatitis C virus infection and type 1 and type 2 diabetes mellitus

Study of changes in lipid profile and insulin resistance in Egyptian patients with chronic hepatitis C genotype 4 in the era of DAAs

Hepatocellular Carcinoma

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