The impact of tumor size on outcomes in patients with upper urinary tract urothelial carcinoma

Milenković-Petronić, Dragica; Milojević, Bogomir; Djokic, M.; Šipetić-Grujičić, Sandra; Milojevic, Isidora Grozdic; Bumbaširević, Uroš; Džamić, Zoran

doi:10.1007/s11255-013-0533-9

Cited by 24 publications

(31 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study confirmed that the tumor size was an independent predictor for worse CSS and overall survival [15]. However, in our research, after adjusting for clinicopathologic variables, the impact of tumor size on CSS was not statistically significant by multivariate analysis, in accordance with Milenkovic-Petronic's study [10]. …”

Section: Discussionsupporting

confidence: 87%

“…In this study, we recognized smaller tumor size (≤3 cm) as an adverse predictor of subsequent IVR in univariate analysis which was not in accordance with several previous studies [10–12, 15, 18]. Our previous study [18] and that of Milenkovic-Petronic et al [10] showed that tumor size was not able to predict IVR up on univariate and multivariate analysis when tumor sizes of 5 cm and 3 cm were set as the cut-off value, respectively. Pieras et al [12] and Espiritu et al [11] confirmed that patients with a tumor size >4 cm or ≥3 cm had a higher rate of IVR.…”

Section: Discussioncontrasting

confidence: 82%

“…A few studies [10–13] about the impact of tumor size on the oncologic outcome in UTUC patients have recently been performed. However, these studies have reached diverse conclusions due to their retrospective and small-volume nature.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Influence of Tumor Size on Oncologic Outcomes for Patients with Upper Tract Urothelial Carcinoma after Radical Nephroureterectomy

Fang

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

Previous studies have reached diverse conclusions about the influence of tumor size on the oncologic outcomes in patients with upper tract urothelial carcinoma (UTUC). In this study, we retrospectively analyzed the records of 687 patients and evaluated how tumor size affected the prognosis of patients with UTUC after surgery. Clinicopathologic characteristics and oncological outcomes were compared according to tumor size (≤3 cm versus >3 cm). During a median follow-up period of 65 months (range 3–144 months), 225 patients (32.8%) died from UTUC and 228 patients (33.2%) experienced intravesical recurrence (IVR). Patients with a larger tumor size tended to have a significantly higher percentage of being male (p = 0.011), tobacco consumption (p = 0.036), lack of preoperative ureteroscopy history (p = 0.003), renal pelvic location (p < 0.001), tumor necrosis (p = 0.003), advanced tumor stage (p < 0.001), higher tumor grade (p = 0.003), and lymph node metastasis (p = 0.018). Univariate analysis revealed that a tumor size >3 cm was significantly associated with worse cancer-specific survival (p = 0.002) and IVR (p = 0.011). However, the influence was not statistically significant after controlling for other factors in the multivariate analysis (hazard ratio [HR] 1.124, p = 0.414 and HR 1.196, p = 0.219). In conclusion, UTUC patients with a larger tumor present aggressive biological characteristics and tend to have a worse prognosis.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussioncontrasting

confidence: 82%

See 1 more Smart Citation

The Influence of Tumor Size on Oncologic Outcomes for Patients with Upper Tract Urothelial Carcinoma after Radical Nephroureterectomy

Fang

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…The present results suggest that tumour size, an objective variable that can be easily measured but has been neglected for a long time, is an important prognostic factor for UTUC treated with RNU. In newly updated guidelines for UTUC , tumour size has been included for the first time as an important preoperative risk factor, based on its impact on survival outcomes; however, no solid evidence has been available to support this, with the exception of a few studies with small sample sizes and indefinite conclusions . The present results, in a multicentre and large sample size setting, represent important new evidence.…”

Section: Discussionmentioning

confidence: 75%

Impact of tumour size on prognosis of upper urinary tract urothelial carcinoma after radical nephroureterectomy: a multi‐institutional analysis of 795 cases

et al. 2016

View full text Add to dashboard Cite

show abstract

“…It originates exclusively from the urothelium and may occur in the lower urinary tract (bladder and urethra) or the upper urinary tract (renal pelvis and ureter) (1,2). Bladder cancer (BC) is the most common type of UC, whereas upper urinary tract urothelial carcinoma (UTUC) is relatively uncommon and accounts for only 5-10% of all UCs (3).…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma

Liu

Huang

et al. 2014

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. Sulfotransferase isoform 1A1 (SULT1A1) is a member of the sulfotransferase family that plays an important role in the biotransformation of numerous carcinogenic and mutagenic compounds through sulfation. A number of case-control studies were conducted to investigate the association between the Arg213His polymorphism in SULT1A1 and the risk of urothelial carcinoma (UC) in humans. However, the results were inconsistent. A meta-analysis based on 10 case-control studies was performed to address this issue. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of this association. Between-study heterogeneity was assessed with the Chi-square-based Q test. Overall, a possibly decreased risk of UC was associated with the SULT1A1 A/A polymorphism for the heterozygote model (OR=0.86, 95% CI: 0.76-0.98, P=0.471). In the subgroup analysis by cancer type, the results indicated that individuals with the G/G genotype had a significantly higher bladder cancer (BC) risk (GA vs. GG: OR=0.88, 95% CI: 0.74-0.99, P=0.626; GA/AA vs. GG: OR=0.85, 95% CI: 0.74-0.97, P=0.504), which was contrary to the results of the upper urinary tract urothelial carcinoma (UTUC) group (AA vs. GG: OR=2.18, 95% CI: 1.28-3.69; AA vs. GA/GG: OR=2.05, 95% CI: 1.24-3.38). In addition, stratification by smoking status demonstrated that the Arg213His polymorphism was associated with a decreased risk of UC in non-smokers (OR=0.70, 95% CI: 0.53-0.92) but not in smokers (OR=0.85, 95% CI: 0.70-1.03) under the dominant model. In conclusion, this meta-analysis demonstrated a significant association between the SULT1A1 Arg213His polymorphism and BC. However, there was insufficient evidence to support a consistent association between this polymorphism and UC, partly due to the differences between BC and UTUC.

show abstract

The impact of tumor size on outcomes in patients with upper urinary tract urothelial carcinoma

Abstract: Tumor size >3 cm was associated with a lower 5-year CSS at Kaplan-Meier analysis, but was not an independent predictor of CSS, bladder-only recurrence, and any recurrence-free survival at multivariable analysis.

Cited by 24 publications

References 21 publications

The Influence of Tumor Size on Oncologic Outcomes for Patients with Upper Tract Urothelial Carcinoma after Radical Nephroureterectomy

The Influence of Tumor Size on Oncologic Outcomes for Patients with Upper Tract Urothelial Carcinoma after Radical Nephroureterectomy

Impact of tumour size on prognosis of upper urinary tract urothelial carcinoma after radical nephroureterectomy: a multi‐institutional analysis of 795 cases

Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma

Contact Info

Product

Resources

About