The impact of transient and persistent acute kidney injury on long-term outcomes after acute myocardial infarction

Goldberg, A.; Kogan, E. A.; Hammerman, Haim; Markiewicz, Walter; Aronson, Doron

doi:10.1038/ki.2009.295

Cited by 113 publications

(94 citation statements)

References 47 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other studies that have evaluated the prognostic value of transient changes in kidney function during hospitalization show conflicting results (24)(25)(26). Such early assessment of recovery of kidney function likely relates to prerenal versus other causes of AKI, and although this has been linked to in-hospital prognosis, it is less helpful for guiding outpatient follow-up of survivors of AKI at hospital discharge and determining long-term prognosis.…”

Section: Discussionmentioning

confidence: 97%

Association between AKI, Recovery of Renal Function, and Long-Term Outcomes after Hospital Discharge

Pannu

James

Hemmelgarn

et al. 2013

Clinical Journal of the American Society of Nephrology

254

188

View full text Add to dashboard Cite

SummaryBackground and objectives This study aimed to determine if recovery of kidney function after AKI modifies the association between AKI during hospitalization and adverse outcomes after discharge.Design, setting, participants, & measurements The effect of renal recovery after AKI was evaluated in a population-based cohort study (n=190,714) with participants identified from a provincial claims registry in Alberta, Canada, between November 1, 2002 and December 31, 2007. AKI was identified by a two-fold increase between prehospital and peak in-hospital serum creatinine (SCr). Recovery was assessed using SCr drawn closest to 90 days after the AKI event. All-cause mortality and a combined renal outcome of sustained doubling of SCr or progression to kidney failure were evaluated.Results Overall, 3.7% of the participants (n=7014) had AKI, 62.7% of whom (n=4400) survived 90 days. In the 3231 patients in whom recovery could be assessed over a median follow-up of 34 months, 30.8% (n=1268) of AKI survivors died and 2.1% (n=85) progressed to kidney failure. Participants who did not recover kidney function had a higher risk for mortality and adverse renal outcomes when AKI participants who recovered to within 25% of baseline SCr were used as the reference group (adjusted mortality hazard ratio (HR), 1.26; 95% confidence interval, 1.10, 1.43) (adjusted renal outcomes HR, 4.13; 95% confidence interval, 3.38, 5.04). Mortality HR was notably higher when participants failed to recover within 55% of baseline.Conclusions Renal recovery after AKI is associated with a lower risk of death or adverse renal outcomes after hospital discharge.

show abstract

Section: Discussionmentioning

confidence: 97%

Association between AKI, Recovery of Renal Function, and Long-Term Outcomes after Hospital Discharge

Pannu

James

Hemmelgarn

et al. 2013

Clinical Journal of the American Society of Nephrology

254

188

View full text Add to dashboard Cite

show abstract

“…The effects of transient (resolved during hospital stay) and persistent AKI (elevations of SCr that persist at patient discharge) on the outcomes of STEMI patients have recently been assessed (27). Goldberg .…”

Section: Acute Renal Failure and Acute Kidney Injury As Risk Factors mentioning

confidence: 99%

Effect of Kidney Disease on Acute Coronary Syndrome

Rodrigues¹,

Bruetto²,

Torres³

et al. 2010

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is highly prevalent worldwide and is associated with an increased risk for adverse outcomes in patients hospitalized with acute coronary syndrome (ACS). In studies including thousands of patients admitted with myocardial infarction, CKD consistently determines a poorer prognosis for ACS patients. In contrast with CKD, information about the effect of acute kidney injury (AKI) on clinical outcomes after ACS is limited. Most data come from retrospective registry databank studies of nonconsecutive patients with a significant number of patients excluded from analyses. There are no prospective studies designed to determine whether AKI strictly diagnosed by the new the Acute Kidney Injury Network (AKIN) or RIFLE (Risk, Injury, Failure, Loss, and End-stage kidney disease) criteria is a risk factor for death after ACS, and there are no data comparing the RIFLE and AKIN criteria for AKI diagnosis after myocardial infarction. This article reviews the most important data on CKD and ACS and the available data on AKI and ACS. The importance of obtaining an early serum creatinine level after admission for ACS and the importance of renal function monitoring during hospitalization are stressed.

show abstract

“…27 In patients surviving ST elevation myocardial infarction, Goldberg found that persistent and increasing severity of acute kidney injury was associated with a higher risk of death. 28 Gottlieb et al reported that 47% of patients admitted with acute decompensated heart failure developed CRS type 1 after three days of hospitalization; Cowie and coworkers found that 50 % developed CRS type 1 after four days. 29,30 Kociol retrospectively studied 20,063 Medicare beneficiaries hospitalized for acute decompensated heart failure and found that 17.8% developed acute kidney injury (defined as an increase in Cr of 0.3 md/dl) and that 64.5% of those patient with acute kidney injury were readmitted and 35.4% died within one year.…”

Section: Pathophysiologymentioning

confidence: 99%

Cardiorenal syndrome

Omar

Zedan

2013

SW Resp Crit Care Chron

View full text Add to dashboard Cite

The case below illustrates a common clinical problem in patients with both acute and chronic cardiac diseases, namely the development of renal dysfunction. This clinical presentation has been called a cardiorenal syndrome; this construct should lead to a better understanding of the interactions between cardiac and renal disorders and the effect of this interaction on management and outcomes. We have reviewed this topic by discussing the definitions, prevalence, pathophysiology, and treatment of cardiorenal syndromes. cAseA 68-year-old man with ischemic heart disease, type 2 diabetes mellitus, hypertension, and hyperlipidemia had been admitted with a ST segment elevation myocardial infarction three months previously. At this follow up visit he presented with gradually increasing shortness of breath, generalized swelling, and some abdominal distension. The patient was admitted to the coronary care unit. On admission, his blood pressure was 110/62 mmHg, and he had bibasilar rales and bipedal pitting edema. The patient had oliguria with a urine output of 10 ml/hour during the first day. The patient's baseline creatinine was 1.2 mg/dl; on admission his creatinine was 2.6 mg/dl and his blood

show abstract

The impact of transient and persistent acute kidney injury on long-term outcomes after acute myocardial infarction

Cited by 113 publications

References 47 publications

Association between AKI, Recovery of Renal Function, and Long-Term Outcomes after Hospital Discharge

Association between AKI, Recovery of Renal Function, and Long-Term Outcomes after Hospital Discharge

Effect of Kidney Disease on Acute Coronary Syndrome

Cardiorenal syndrome

Contact Info

Product

Resources

About