The impact of transcranial direct current stimulation (tDCS) combined with modified constraint-induced movement therapy (mCIMT) on upper limb function in chronic stroke: a double-blind randomized controlled trial

Rocha, Sérgio; Silva, Evelyn; Foerster, Águida; Wiesiolek, Carine Carolina; Chagas, Anna Paula; Machado, G.G.; Baltar, Adriana; Monte-Silva, Kátia

doi:10.3109/09638288.2015.1055382

Cited by 90 publications

(93 citation statements)

References 53 publications

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“…For cerebral palsy, it was described that anodal tDCS applied over the cerebellum combined with treadmill training can improve signs of ataxia in these patients (Grecco et al, in press). Although the small sample size of this pilot study makes it difficult to generalize results, the significant performance improvements associated with anodal tDCS are consistent with similar effects obtained in other motor pathologies in adults, for example improvements in motor function of chronic stroke patients (Rocha et al, 2016). In another study exploring the effects of tDCS on clinical symptoms in cerebral palsy, the anodal electrode was placed over the primary motor cortex and the cathode over the contralateral supraorbital region and such the most often used montage for motor cortex stimulation in adults (Salvador et al, 2015).…”

Section: Cerebral Palsy and Dystoniamentioning

confidence: 58%

Applications of transcranial direct current stimulation in children and pediatrics

Rivera-Urbina¹,

Nitsche

Vicario

et al. 2017

Reviews in the Neurosciences

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AbstractTranscranial direct current stimulation (tDCS) is a neuromodulatory noninvasive brain stimulation tool with potential to increase or reduce regional and remote cortical excitability. Numerous studies have shown the ability of this technique to induce neuroplasticity and to modulate cognition and behavior in adults. Clinical studies have also demonstrated the ability of tDCS to induce therapeutic effects in several central nervous system disorders. However, knowledge about its ability to modulate brain functions in children or induce clinical improvements in pediatrics is limited. The objective of this review is to describe relevant data of some recent studies that may help to understand the potential of this technique in children with specific regard to effective and safe treatment of different developmental disorders in pediatrics. Overall, the results show that standard protocols of tDCS are well tolerated by children and have promising clinical effects. Nevertheless, treatment effects seem to be partially heterogeneous, and a case of a seizure in a child with previous history of infantile spasms and diagnosed epilepsy treated with tDCS for spasticity was reported. Further research is needed to determine safety criteria for tDCS use in children and to elucidate the particular neurophysiological changes induced by this neuromodulatory technique when it is applied in the developing brain.

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Section: Cerebral Palsy and Dystoniamentioning

confidence: 58%

Applications of transcranial direct current stimulation in children and pediatrics

Rivera-Urbina¹,

Nitsche

Vicario

et al. 2017

Reviews in the Neurosciences

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“…Bilateral stimulation was administered in majority of trails, while in 2 studies anodal stimulation was investigated [16] and cathodal stimulation in one study [18]; The current intensity varies from 1 mA to 2 mA. In most studies the hemisphere affected by the anode electrode and the cathode electrode positioned on the hemisphere has been stimulated; only 3 studies have used monocephalic montage [6,16,18]. The duration of stimulation ranged from 9 min to 30 min.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies were considered for a total of 178 subjects included [6,[12][13][14][15][16][17][18]. Computer literacy research has been focused on post-stroke motor recovery studies by administering non-invasive brain stimulation (NIBS) including transcranial direct current stimulation (tDCS); the research period of the literature is between January 2005 and May 2016.…”

Section: Literature Research and Selection Of Studiesmentioning

confidence: 99%

“…Some studies suggest that the amount of transcallosum inhibition may be positively linked to the degree of motor disability [10,6], making it plausible the hypothesis that this phenomenon is a maladaptive process with effects resulting from the impairment of motor function [11].…”

Section: Introductionmentioning

confidence: 99%

“…Transcranial direct current stimulation (tDCS) is a noninvasive, well-tolerated, bidirectional brain stimulation technique whose use does not result in the occurrence of auditory and somatosensory perceptions after the initial minutes [1][2][3][4][5], using a weak current applied on the scalp, through two electrodes of sponge soaked in saline solution to modulate spontaneous neuronal discharge frequency in painless and reversible [6,7]. The effects are polar-dependent; Anodal stimulation induces depolarization of the neural membrane, while cathodal stimulation induces hyperpolarization [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Transcranial Direct Current Stimulation as Support for Neurorehabilitation Therapy: A Meta-analysis of Available Studies

Pa¹,

Marini²

2017

Int J Phys Med Rehabil

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Transcranial direct current stimulation (tDCS) is a non-invasive, well-tolerated, brain stimulation technique, using a weak current applied on the scalp. Rational of tDCS use has been based on the assumption of the post-stroke inter-hemispheric competition model, resulting in a hypo-excitability hemispheric lesion and a hyper-excitability healthy hemisphere, to improve the recovery of motor function. Several small studies have been published but the efficacy of tDCS is not established. We performed a systematic review of published studies to assess efficacy of tDCS on motor function of patients with stroke. A thorough search of main databases has been performed to identify randomized, controlled studies on efficacy of tDCS in patients with stroke. The values derived from the primary outcome measures of these studies have been standardized to make them comparable; eight comparisons were planned: degree of dependence, improvement of upper limb, improvement of global motor function, improvement of lower limb and visual perception; comparison between anode stimulation and sham, anode stimulation and followup. 8 studies have been included in the meta-analysis. 3 studies have been excluded because of lack of statistical data, non-randomized assignment and lack of a control group; 178 participants have been included altogether. Most of comparisons did not produce significant results; however a significant improvement of dependence scores (p=0.02), of lower limb index (p=0.02), and of visual perception (p=0.02) have been found. Despite the encouraging results by neurophysiological and instrumental investigations, in some heterogeneous cases, our study shows that there is a need to conduct studies with larger sample sizes.

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Transcranial direct current stimulation (tDCS) for improving activities of daily living, and physical and cognitive functioning, in people after stroke

Elsner

Kügler

Pohl

et al. 2020

Cochrane Database of Systematic Reviews

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The impact of transcranial direct current stimulation (tDCS) combined with modified constraint-induced movement therapy (mCIMT) on upper limb function in chronic stroke: a double-blind randomized controlled trial

Cited by 90 publications

References 53 publications

Applications of transcranial direct current stimulation in children and pediatrics

Applications of transcranial direct current stimulation in children and pediatrics

Efficacy of Transcranial Direct Current Stimulation as Support for Neurorehabilitation Therapy: A Meta-analysis of Available Studies

Transcranial direct current stimulation (tDCS) for improving activities of daily living, and physical and cognitive functioning, in people after stroke

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