The impact of total antioxidant capacity on pulmonary function in asthma patients

Sánchez-Padilla, Elisabeth; Ardizzoni, Elisa; Sauvageot, Delphine; Ahoua, Laurence; Martin, Anandi; Varaine, Francis; Adatu-Engwau, F.; Akeche, G; Salaniponi, F. M. L.; Bonnet, Maryline

doi:10.5588/ijtld.12.0842

Cited by 20 publications

(15 citation statements)

References 7 publications

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“…The lower rate of resistance to one or more first line anti-TB drug was reported from Jimma (18.4%) [14] and Arsi (18.2%) [15]. A comparable rate of resistance has been reported from similar surveys from Uganda (28.6%) [16] but the higher rate of resistance (56%) to one or more first line drug was also reported from Calabar, Nigeria [17]. The similar previous study reported drug resistance to one or more anti-TB drugs in different African countries was within the range of 28.6% -56% [18].…”

Section: Discussionsupporting

confidence: 59%

Drug Resistance Pattern in Pulmonary Tuberculosis Patients and Risk Factors Associated with Multi-Drug Resistant Tuberculosis

Maharjan¹,

Singh²,

Khadka³

et al. 2017

JTR

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Introduction: Anti-tuberculosis drug resistance is a major problem in tuberculosis (TB) control programme, particularly multi-drug resistance TB (MDR-TB) in Nepal. Drug resistance is difficult to treat due to its associated cost and side effects. The objective of this study was to assess the drug resistance pattern and assess risk factor associated with MDR-TB among pulmonary tuberculosis patients attending National Tuberculosis Center. Methodology: The comparative cross sectional study was conducted at National Tuberculosis Center during August 2015 to February 2015. Early morning sputum samples were collected from pulmonary tuberculosis suspected patients and subjected to Ziehl-Neelsen staining and fluorochrome staining and culture on Lowenstein-Jensen (LJ) medium. Drug Susceptibility test was performed on culture positive isolates by using proportion method. Univariate and multivariate analysis was computed to assess the risk factors of MDR-TB. Results: Out of 223 sputum samples, 105 were fluorochrome staining positive, 85 were ZN staining positive and 102 were culture positive. Out of 102 culture positive isolates, 37.2% were resistance to any four anti-TB drugs. 11 (28.9%) were initial drug resistance and 28 (43.7%) were acquired drug resistance. The overall prevalence of MDR-TB was 11.7%, of which 2 (5.3%) were initial MDR-TB and 10 (15.6%) were acquired MDR-TB. Univariate and multivariate analysis showed female were significantly associated (P = 0.05) with MDR-TB. Conclusion: Drug resistance TB particularly MDR-TB is high. The most common resistance pattern observed in this study was resistance to both isoniazid and rifampicin. Female were found to be associated with MDR-TB. Thus, early diagnosis of TB and provision of culture and DST are crucial in order to combat the threat of DR-TB.

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Section: Discussionsupporting

confidence: 59%

Drug Resistance Pattern in Pulmonary Tuberculosis Patients and Risk Factors Associated with Multi-Drug Resistant Tuberculosis

Maharjan¹,

Singh²,

Khadka³

et al. 2017

JTR

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“…Lower frequencies of drug resistances were reported from yet other Ethiopian regions [15], [16], [17]. Two studies from other East African regions, including Uganda [18] and the city of Nairobi [19], reported higher frequencies of resistance, 28.6 and 30% respectively. The differences in overall prevalence of drug resistance among the different study settings could be due to difference in sample size, design of the study, study participant, access to healthcare facilities and effectiveness of TB control programs.…”

Section: Discussionmentioning

confidence: 76%

Mycobacterium tuberculosis in central Ethiopia: drug sensitivity patterns and association with genotype

Bedewi

Mekonnen

Worku³

et al. 2017

New Microbes and New Infections

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Drug resistance tuberculosis (TB) and the emergence of multidrug resistant (MDR) isolates are significant concerns regarding TB control programs in several countries. This study was undertaken to evaluate the drug sensitivity of Mycobacterium tuberculosis and to assess its association with strains and lineages of M. tuberculosis.A total of 279 M. tuberculosis strains isolated from Central Ethiopia were tested for their drug sensitivity patterns to first line TB drugs using the conventional proportion method on Löwenstein Jensen media. The association between drug sensitivity and strain type was assessed on 263 isolates of the 279 isolates.Of the 268 M. tuberculosis isolates obtained from new cases, 209 (78%) were susceptible to first line TB drugs, and 59 (22.2%) bacterial isolates were resistant to at least one of the first line drugs. The highest mono-resistance (7.5%) pertained to streptomycin (STM). Remarkably, seven of eleven isolates (63.6%) previous treatment for TB were resistant to at least one of the first line drugs. The prevalence of MDR-TB was 1.5% (4/268) for newly identified TB cases, all of which were members of the Euro-American Lineage. There was no statistically significant association (P > 0.05) between drug sensitivity, and either strains, sub-lineages or main lineages of M. tuberculosis.A significant proportion of M. tuberculosis was resistant to at least one first line anti-TB drug. Moreover, the frequencies of resistance to either isoniazid or rifampicin were high compared to data that were previously reported in some part of the country.

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“…A comparable rate of resistance (21%) [22] was reported from Addis Ababa, whereas higher rates of resistance (32.5%) [3], (30.1%) [23], and (25%) [24] have also been reported from similar surveys in the country in the previous years. Studies from Uganda [25] and Nairobi [26] reported a higher resistance level of (28.6%) and (30%), respectively. The variations in overall prevalence of drug resistance among the different study settings could be due to difference in sample size (small sample size could overestimate the proportion), irregular supply of antituberculosis drugs, poor TB case management (inadequate diagnosis, treatment, and follow-up), and poor treatment compliance.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Drug Resistance Patterns ofMycobacterium tuberculosisamong New Smear Positive Pulmonary Tuberculosis Patients in Eastern Ethiopia

Seyoum

Demissie

Worku

et al. 2014

Tuberculosis Research and Treatment

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The study aimed at determining the prevalence and drug resistance patterns of Mycobacterium tuberculosis among new smear positive pulmonary tuberculosis patients visiting TB diagnosis and treatment facilities at selected health facilities in eastern Ethiopia. A cross-sectional study was conducted between October 2011 and May 2013. A total of 408 new adult pulmonary TB patients (≥ 18 years) were enrolled in this study. Three consecutive sputum samples (spot, morning, and spot) were collected from each patient and transported to the Armauer Hansen Research Institute TB laboratory located in Addis Ababa for culture on Lowenstein Jensen slant media. DST was performed on 357 (87.5%) of the patient samples for isoniazid (H), rifampicin (R), ethambutol (E), and streptomycin (S) using the standard proportion method. The rate of resistance to any one drug was 23%. Any resistance to H, S, R, and E was 14%, 11.5%, 2.8%, and 0.3%, respectively. The highest proportion of monoresistance was observed against H (9.5%). MDRTB was detected in 1.1% of the patients. Any drug resistance was associated with HIV infection (COR = 3.7, 95% CI 1.905–7.222) (P = 0.000). Although the prevalence of MDRTB is relatively low in the study area, high prevalence of H resistance is a serious concern demanding close monitoring. Expanding diagnostic capacity for mycobacterial culture and DST is a vital step in this regard.

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The impact of total antioxidant capacity on pulmonary function in asthma patients

Cited by 20 publications

References 7 publications

Drug Resistance Pattern in Pulmonary Tuberculosis Patients and Risk Factors Associated with Multi-Drug Resistant Tuberculosis

Drug Resistance Pattern in Pulmonary Tuberculosis Patients and Risk Factors Associated with Multi-Drug Resistant Tuberculosis

Mycobacterium tuberculosis in central Ethiopia: drug sensitivity patterns and association with genotype

Prevalence and Drug Resistance Patterns ofMycobacterium tuberculosisamong New Smear Positive Pulmonary Tuberculosis Patients in Eastern Ethiopia

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