The impact of time-of-flight, resolution recovery, and noise modelling in reconstruction algorithms in non-solid-state detectors PET/CT scanners: – multi-centric comparison of activity recovery in a 68Ge phantom

Chauvie, Stéphane; Bergesio, Fabrizio; Ponti, Elena De; Morzenti, Sabrina; Maggi, Adriano De; Ragazzoni, Matteo; Chiesa, Carlo; Matheoud, Roberta

doi:10.1016/j.ejmp.2020.06.002

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…Several investigators have successfully utilized TOF-PET with the BPL reconstruction algorithms [30,36,37]. In the most significant regarding the effect of TOF on the BPL reconstruction, Chauvie et al evaluated the effect of various acquisition and reconstruction parameters on RC using Ga-68; one of these evaluations included comparing the RC for images reconstructed using BPL and BPL+TOF algorithms [38]. Chauvie et al's work showed the BPL+TOF reconstructions ranged from being not significantly different to significantly better than BPL only reconstructions.…”

Section: B >mentioning

confidence: 99%

Optimizing scan time and bayesian penalized likelihood reconstruction algorithm in copper-64 PET/CT imaging: a phantom study

Monsef,

Sheikhzadeh,

Steiner

et al. 2024

Biomed. Phys. Eng. Express

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Objectives: The aim of this study was to evaluate Cu-64 PET phantom image quality using Bayesian Penalized Likelihood (BPL) and Ordered Subset Expectation Maximum with point-spread function modeling (OSEM-PSF) reconstruction algorithms. In the BPL, the regularization parameter β was varied to identify the optimum value for image quality. In the OSEM-PSF, the effect of acquisition time was evaluated to assess the feasibility of shortened scan duration. Methods: A NEMA IEC PET body phantom was filled with known activities of water soluble Cu-64. The phantom was imaged on a PET/CT scanner and was reconstructed using BPL and OSEM-PSF algorithms. For the BPL reconstruction, various β values (150, 250, 350, 450, and 550) were evaluated. For the OSEM-PSF algorithm, reconstructions were performed using list-mode data intervals ranging from 7.5 to 240 seconds. Image quality was assessed by evaluating the signal to noise ratio (SNR), contrast to noise ratio (CNR), and background variability (BV). Results: The SNR and CNR were higher in images reconstructed with BPL compared to OSEM-PSF. Both the SNR and CNR increased with increasing β, peaking at β = 550. The CNR for all β, sphere sizes and tumor-to-background ratios (TBRs) satisfied the Rose criterion for image detectability (CNR > 5). BPL reconstructed images with β = 550 demonstrated the highest improvement in image quality. For OSEM-PSF reconstructed images with list-mode data duration > 120 seconds, the noise level and CNR were not significantly different from the baseline 240-second list-mode data duration.Conclusions: BPL reconstruction improved Cu-64 PET phantom image quality by increasing SNR and CNR relative to OSEM-PSF reconstruction. Additionally, this study demonstrated scan time can be reduced from 240 to 120 seconds when using OSEM-PSF reconstruction while maintaining similar image quality. This study provides baseline data that may guide future studies aimed to improve clinical Cu-64 imaging.

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Section: B >mentioning

confidence: 99%

Optimizing scan time and bayesian penalized likelihood reconstruction algorithm in copper-64 PET/CT imaging: a phantom study

Monsef,

Sheikhzadeh,

Steiner

et al. 2024

Biomed. Phys. Eng. Express

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show abstract

“…The loss of uptake, and hence of sensitivity, when decreasing the lesion size is described by the recovery curves shown in Figure 5. Modern reconstruction algorithms mitigate this effect modelling the noise and the signal (68) giving the possibility to the user to tune some parameters of the algorithm in order to obtain an image that could be reported with the best accuracy by the nuclear medicine physician. But this tuning will affect the reproducibility of SUV for small lesions across different scanner.…”

Section: Reproducibility Of Suv-related Indexes For Pet/ct Reporting In Lymphomamentioning

confidence: 99%

PET/CT Imaging of Lymphoma Outside the Western World

Gabus,

Pavlovsky,

Eleta

et al. 2021

Lymphoma

Self Cite

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Influence of reconstruction techniques on PET/CT image quality and quantitative accuracy: a phantom study

Su,

Geng,

Liu

et al. 2023

Radiat Detect Technol Methods

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The impact of time-of-flight, resolution recovery, and noise modelling in reconstruction algorithms in non-solid-state detectors PET/CT scanners: – multi-centric comparison of activity recovery in a 68Ge phantom

Cited by 4 publications

References 27 publications

Optimizing scan time and bayesian penalized likelihood reconstruction algorithm in copper-64 PET/CT imaging: a phantom study

Optimizing scan time and bayesian penalized likelihood reconstruction algorithm in copper-64 PET/CT imaging: a phantom study

PET/CT Imaging of Lymphoma Outside the Western World

Influence of reconstruction techniques on PET/CT image quality and quantitative accuracy: a phantom study

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