It is well-known that active galactic nuclei (AGN) are accompanied by winds and outflows, some of which may reach weakly relativistic speeds of about 10 percent the speed of light. Yet, in spite of their ubiquity, the impact of AGN outflows in modulating surface habitability of terrestrial planets on galactic scales, using the Milky Way as the basis for comparison, is poorly investigated and inadequately understood. In this work, we address this issue by focusing on two key mechanisms: AGN winds can heat atmospheres and drive atmospheric escape, as well as stimulate the formation of nitrogen oxides and thence cause ozone depletion. By developing simple models, we estimate the maximal distance up to which these deleterious effects are rendered significant for Earth-like planets in the Milky Way, and thereby demonstrate that this value may extend to 1 kpc. In the case of quasars hosting larger supermassive black holes, such effects could actually influence the AGN host galaxy as a whole.