The Impact of Thyroid Disease on Sexual Dysfunction in Men and Women

Gabrielson, Andrew; Sartor, Rita A.; Hellstrom, Wayne J.G.

doi:10.1016/j.sxmr.2018.05.002

Cited by 76 publications

(68 citation statements)

References 44 publications

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“…Moreover, it has been demonstrated to be superior to other alternative therapies [10]. Its daily intake has been related to the improvement in symptoms such as growth deficits, severe fatigue, constipation, anxiety or depression [10,17], nevertheless, some symptoms seem to persist [5,11,12].…”

Section: Discussionmentioning

confidence: 99%

“…The exclusion criteria were: (1) abnormal TSH levels, (2) being pregnant or lactating, (3) family history of clinical or subclinical hypothyroidism, (4) consumption of medications that may interfere with thyroid function or sexual response (methimazole/thiamazole, chemotherapy, etc. ), (5) diagnosis of psychiatric, endocrine, gynecological or other diseases that may affect sexuality.…”

Section: Design and Study Populationmentioning

confidence: 99%

“…Once TSH levels are normalized (0.4−4 IU/mL), women have annual reviews to control the disease [10]. The normalization of TSH levels leads to the reduction in hypothyroidism symptoms, including sexual dysfunction [5,6]. However, not all the patients seem to obtain the same benefit from the treatment, and occasionally, some symptoms persist even after reaching euthyroidism [5,11,12].…”

Section: Introductionmentioning

confidence: 99%

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Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control

Romero-Gómez

Guerrero-Alonso

Carmona‐Torres

et al. 2020

IJERPH

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Background: Levothyroxine is the most common treatment to normalize thyroid hormones levels and to reduce primary hypothyroidism symptoms. Aim: To assess sexual function in women with levothyroxine-treated hypothyroidism and women without hypothyroidism. Methods: A case-control study was performed with 152 women with levothyroxine-treated hypothyroidism and 238 women without hypothyroidism. An online survey was used to collect socio-demographic data and the answers to the Women Sexual Function (WSF) questionnaire. Results: Women with levothyroxine-treated hypothyroidism showed a higher prevalence of sexual dysfunction than women in the control group (31.60% vs. 16.40%), furthermore the presence of hypothyroidism increased the risk of sexual dysfunction (p = 0.002, OR: 2.29 (1.36−3.88)). The most affected domains were ‘desire’ (p < 0.001), ‘arousal’ (p = 0.003) and ‘penetration pain’ (p = 0.020). In hypothyroid women, age increased the risk of sexual dysfunctions (p = 0.009, OR: 1.07 (1.01−1.12)), however when age was adjusted (ANCOVA) the sexual dysfunction remained in women with hypothyroidism in all domains. Conclusions: Hypothyroidism is associated with an increase in the prevalence of sexual dysfunction even if treated with levothyroxine and thyroid-stimulating hormone (TSH) levels are normalized. Relevance to clinical practice: Sexual function in hypothyroid women should be assessed before and after starting the treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Design and Study Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control

Romero-Gómez

Guerrero-Alonso

Carmona‐Torres

et al. 2020

IJERPH

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“…There is a high (>20%) prevalence of hypothyroidism in patients with T2DM, hypertension, and patients having both [189].Hypothyroidism can directly cause obstructive sleep apnea (OSA) [190,191], Bruyneel et.al, 2019 reported 16% of OSA patients had a thyroid problem and 8% of these were newly diagnosed with subclinical hypothyroidism (SCH) [192], over 50% of the patients studied did not receive any treatment, found in a recent Egyptian study [193]. Both hypothyroidism and hyperthyroidism were strongly associated with erectile and ejaculatory dysfunction: hypothyroidism with delayed ejaculation, hyperthyroidism with pre-mature ejaculation [194]. Yuan et.al, 2019 reported highest prevalence of vitiligo in subclinical hypothyroidism, among 6 types of thyroid disorders [195].…”

Section: Thyroid Disordersmentioning

confidence: 97%

Clinical Pharmacists in Chronic Care

Mohiuddin¹

2019

GJMR

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Pharmacy practice has changed significantly lately. The professionals have the chance to contribute straightforwardly to patient consideration so as to lessen morbimortality identified with medication use, promoting wellbeing and preventing diseases. Healthcare organizations worldwide are under substantial pressure from increasing patient demand. Unfortunately, a cure is not always possible particularly in this era of chronic complications, and the role of physicians has become limited to controlling and palliating symptoms.The increasing population of patients with longterm conditions are associated with high levels of morbidity, healthcare costs and GP workloads. Clinical pharmacy took over an aspect of medical care that had been partially abandoned by physicians. Overburdened by patient loads and the explosion of new drugs, physicians turned to pharmacists more and more for drug information, especially within institutional settings. Once relegated to counting and pouring, pharmacists headed institutional reviews of drug utilization and served as consultants to all types of health-care facilities. In addition, when clinical pharmacists are active members of the care team, they enhance proficiency by: Providing critical input on medicine use and dosing. Working with patients to solve problems with their medications and improve compliance.

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“…50 Both hypothyroidism and hyperthyroidism can lead to ED and ED is more prevalent in men with dysthyroidism than in controls. 51 Treatment of hypothyroidism and hyperthyroidism may improve ED. 52 Therefore, screening for thyroid dysfunction in men presenting with ED is recommended.…”

Section: Endocrinementioning

confidence: 99%

Erectile Dysfunction: A Review of Comprehensive Treatment Options for Optimal Outcome

Retzler¹

2019

JRM

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Erectile dysfunction (ED) is common with aging. Formerly ED treatment was offered mainly by urologists, but the approval and widespread use of phosphodiesterase inhibitors has enabled primary care clinicians to provide targeted ED treatment. Although large, multicenter clinical trials have shown efficacy and safety with these drugs, they are ineffective in 30-35% of men, may cause sideeffects, and do not improve the underlying pathology. A thorough understanding of erectile physiology and causes of ED and a comprehensive treatment plan addressing all contributing factors may be more effective than pharmaceutical management and may improve aspects of psychological and physical health beyond erectile problems.

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The Impact of Thyroid Disease on Sexual Dysfunction in Men and Women

Cited by 76 publications

References 44 publications

Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control

Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control

Clinical Pharmacists in Chronic Care

Erectile Dysfunction: A Review of Comprehensive Treatment Options for Optimal Outcome

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