Objective In the Caribbean, cancer ranks as the second leading cause of mortality. Without interventions, the incidence is predicted to increase by 66% within the next decade, with over 56,000 women being diagnosed with cervical cancer annually and more than 28,000 succumbing to the disease. However, life-saving prevention and treatment measures are available. This research sought to explore potential differences in knowledge, attitudes, and willingness to receive HPV vaccinations among male and female undergraduate students at a chosen Community College in St. Lucia.Methods This investigation utilized a descriptive, quantitative, and cross-sectional approach, with participants (n = 100) chosen through random sampling and completing 59-item self-administered questionnaires addressing the targeted variables. Multivariable statistical techniques were employed to determine independent predictors for HPV-vaccine acceptance among participants.Results Despite recognizing the associated risks, the findings highlighted a substantial deficit in public health promotion efforts. Firstly, although HPV is widespread in St. Lucia and causes cancer in both genders, there is insufficient awareness-raising about HPV. Secondly, the vaccine is not accessible in St. Lucia. Thirdly, the high expenses associated with the vaccine ($500 US) and HPV test ($275 EC) serve as barriers to obtaining them. Lastly, HPV vaccine uptake was minimal among participants; only 7 out of 100 had been vaccinated and received it in the US. Despite low vaccine uptake, 53% acknowledged the urgent need for vaccination.Conclusions Integrating HPV vaccination within healthcare and HPV awareness initiatives can yield positive outcomes in mitigating cancer's long-term impact on St. Lucia's male and female populations. Educational programs could prove advantageous in enhancing knowledge about HPV and vaccinations.